ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	186/1065	423/7206	6.24099603662e-51
ko04724	Glutamatergic synapse	85/1065	152/7206	9.43962241884e-33
ko05033	Nicotine addiction	47/1065	56/7206	7.67261587997e-31
ko05032	Morphine addiction	65/1065	110/7206	3.86586205464e-27
ko04713	Circadian entrainment	71/1065	136/7206	4.89764549333e-25
ko04728	Dopaminergic synapse	83/1065	185/7206	2.35163827955e-23
ko04727	GABAergic synapse	60/1065	110/7206	1.28118827776e-22
ko04721	Synaptic vesicle cycle	47/1065	80/7206	8.79025552477e-20
ko04725	Cholinergic synapse	71/1065	160/7206	8.82085552906e-20
ko04024	cAMP signaling pathway	101/1065	279/7206	1.25415153102e-19
ko04723	Retrograde endocannabinoid signaling	73/1065	175/7206	1.95272211876e-18
ko04020	Calcium signaling pathway	92/1065	265/7206	1.29202297204e-16
ko04744	Phototransduction	26/1065	36/7206	1.12403535342e-14
ko04726	Serotonergic synapse	56/1065	137/7206	5.90938017489e-14
ko04742	Taste transduction	34/1065	61/7206	1.01341599331e-13
ko04911	Insulin secretion	50/1065	117/7206	1.72307601289e-13
ko04921	Oxytocin signaling pathway	73/1065	209/7206	2.11644127039e-13
ko05031	Amphetamine addiction	42/1065	91/7206	6.62689264022e-13
ko04261	Adrenergic signaling in cardiomyocytes	68/1065	205/7206	1.80032429552e-11
ko04720	Long-term potentiation	42/1065	99/7206	2.06056343603e-11
ko03040	Spliceosome	1/1065	145/7206	3.58782797188e-09
ko05030	Cocaine addiction	30/1065	73/7206	3.79224697264e-08
ko04970	Salivary secretion	35/1065	95/7206	7.77975867687e-08
ko04070	Phosphatidylinositol signaling system	39/1065	112/7206	9.80680518428e-08
ko04925	Aldosterone synthesis and secretion	37/1065	105/7206	1.71344263745e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1065	74/7206	2.19276571301e-07
ko04010	MAPK signaling pathway	81/1065	321/7206	4.69720196596e-07
ko04022	cGMP-PKG signaling pathway	59/1065	216/7206	1.26155375406e-06
ko04971	Gastric acid secretion	33/1065	98/7206	2.09954051805e-06
ko04060	Cytokine-cytokine receptor interaction	8/1065	191/7206	3.74981027677e-06
ko05322	Systemic lupus erythematosus	5/1065	151/7206	6.92998057505e-06
ko04360	Axon guidance	60/1065	233/7206	8.1904498809e-06
ko05203	Viral carcinogenesis	17/1065	277/7206	8.64343173557e-06
ko05168	Herpes simplex infection	8/1065	182/7206	1.05257547985e-05
ko04621	NOD-like receptor signaling pathway	6/1065	157/7206	1.15744966903e-05
ko04740	Olfactory transduction	27/1065	80/7206	1.8416714918e-05
ko03013	RNA transport	7/1065	166/7206	1.91775676389e-05
ko04966	Collecting duct acid secretion	13/1065	26/7206	2.37250599529e-05
ko04730	Long-term depression	26/1065	78/7206	3.25910229231e-05
ko04072	Phospholipase D signaling pathway	51/1065	197/7206	3.72598140877e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1065	79/7206	4.03275987237e-05
ko04745	Phototransduction - fly	16/1065	38/7206	4.13275078347e-05
ko04514	Cell adhesion molecules (CAMs)	37/1065	130/7206	4.84315948268e-05
ko04014	Ras signaling pathway	66/1065	279/7206	6.56947732195e-05
ko04924	Renin secretion	27/1065	86/7206	8.34237107168e-05
ko04141	Protein processing in endoplasmic reticulum	10/1065	184/7206	8.42448061362e-05
ko04972	Pancreatic secretion	32/1065	111/7206	0.000120185549565
ko04612	Antigen processing and presentation	1/1065	77/7206	0.000128231407327
ko04120	Ubiquitin mediated proteolysis	6/1065	138/7206	0.000138528713362
ko04260	Cardiac muscle contraction	29/1065	98/7206	0.000144685047061
ko04110	Cell cycle	7/1065	145/7206	0.00020753588458
ko04540	Gap junction	35/1065	128/7206	0.000210484877725
ko05414	Dilated cardiomyopathy	31/1065	112/7206	0.00038333809404
ko04750	Inflammatory mediator regulation of TRP channels	33/1065	122/7206	0.00041324444717
ko05164	Influenza A	10/1065	167/7206	0.000557156196556
ko03008	Ribosome biogenesis in eukaryotes	2/1065	79/7206	0.000628441104257
ko04915	Estrogen signaling pathway	34/1065	131/7206	0.000697692136699
ko04064	NF-kappa B signaling pathway	4/1065	96/7206	0.00130123983951
ko04930	Type II diabetes mellitus	17/1065	54/7206	0.00158935504591
ko04923	Regulation of lipolysis in adipocytes	22/1065	77/7206	0.00174049122112
ko05110	Vibrio cholerae infection	19/1065	63/7206	0.00183880209004
ko00562	Inositol phosphate metabolism	24/1065	89/7206	0.00237968182057
ko04626	Plant-pathogen interaction	8/1065	18/7206	0.00243555975719
ko05169	Epstein-Barr virus infection	16/1065	206/7206	0.00269346486009
ko00480	Glutathione metabolism	1/1065	55/7206	0.00332620689622
ko04610	Complement and coagulation cascades	3/1065	79/7206	0.00350023584381
ko04146	Peroxisome	4/1065	89/7206	0.00377126049187
ko05205	Proteoglycans in cancer	24/1065	271/7206	0.00388099325333
ko05162	Measles	7/1065	120/7206	0.00390730559076
ko00240	Pyrimidine metabolism	6/1065	110/7206	0.00399614260066
ko05140	Leishmaniasis	3/1065	75/7206	0.00486895535262
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1065	100/7206	0.0064959319896
ko00310	Lysine degradation	3/1065	73/7206	0.00707349606698
ko04973	Carbohydrate digestion and absorption	13/1065	42/7206	0.00707359856225
ko05230	Central carbon metabolism in cancer	21/1065	81/7206	0.00718093406314
ko04371	Apelin signaling pathway	39/1065	177/7206	0.00959394205648
ko05144	Malaria	1/1065	45/7206	0.010596153966
ko00071	Fatty acid degradation	1/1065	45/7206	0.010596153966
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1065	14/7206	0.0106516733536
ko03420	Nucleotide excision repair	1/1065	46/7206	0.0107560838549
ko05145	Toxoplasmosis	9/1065	126/7206	0.0112026634441
ko04510	Focal adhesion	22/1065	240/7206	0.0121562760941
ko05321	Inflammatory bowel disease (IBD)	2/1065	56/7206	0.0129039864608
ko04657	IL-17 signaling pathway	5/1065	87/7206	0.0141770232644
ko04960	Aldosterone-regulated sodium reabsorption	12/1065	41/7206	0.0142617372916
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1065	59/7206	0.0146609351263
ko05214	Glioma	20/1065	79/7206	0.0153273319446
ko04922	Glucagon signaling pathway	29/1065	128/7206	0.0162691626378
ko03022	Basal transcription factors	1/1065	44/7206	0.0164856622174
ko04722	Neurotrophin signaling pathway	35/1065	160/7206	0.0172892594008
ko04350	TGF-beta signaling pathway	7/1065	103/7206	0.0172946735085
ko04071	Sphingolipid signaling pathway	35/1065	162/7206	0.0181489798855
ko05231	Choline metabolism in cancer	30/1065	134/7206	0.0186996710557
ko00280	Valine, leucine and isoleucine degradation	2/1065	54/7206	0.0189616659287
ko04015	Rap1 signaling pathway	55/1065	278/7206	0.0197778943012
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1065	40/7206	0.0235263200064
ko05131	Shigellosis	5/1065	82/7206	0.026882920027
ko00330	Arginine and proline metabolism	3/1065	61/7206	0.028027940814
ko04214	Apoptosis - fly	4/1065	72/7206	0.0281508288127
ko04622	RIG-I-like receptor signaling pathway	3/1065	62/7206	0.0287288889998
ko04964	Proximal tubule bicarbonate reclamation	9/1065	29/7206	0.0297902211835
ko05034	Alcoholism	47/1065	238/7206	0.0324257950225
ko05133	Pertussis	6/1065	87/7206	0.0333701469019
ko00630	Glyoxylate and dicarboxylate metabolism	1/1065	38/7206	0.0355896972151
ko03410	Base excision repair	1/1065	38/7206	0.0355896972151
ko05161	Hepatitis B	16/1065	173/7206	0.0388568171885
ko04658	Th1 and Th2 cell differentiation	7/1065	96/7206	0.041207610201
ko05166	HTLV-I infection	31/1065	292/7206	0.0429732962387
ko04062	Chemokine signaling pathway	40/1065	201/7206	0.0434579521801
ko05010	Alzheimer's disease	40/1065	202/7206	0.0444717309562
ko03018	RNA degradation	6/1065	84/7206	0.0445980487857
ko04115	p53 signaling pathway	5/1065	74/7206	0.0484021505417