ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 110/670 423/7206 2.42354973133e-25 ko04721 Synaptic vesicle cycle 43/670 80/7206 3.91150313379e-24 ko04724 Glutamatergic synapse 56/670 152/7206 7.42516122409e-21 ko05033 Nicotine addiction 32/670 56/7206 2.45435168103e-19 ko04727 GABAergic synapse 42/670 110/7206 1.45173148843e-16 ko04728 Dopaminergic synapse 56/670 185/7206 2.45060308845e-16 ko05032 Morphine addiction 41/670 110/7206 9.15302245744e-16 ko04723 Retrograde endocannabinoid signaling 51/670 175/7206 3.11945245874e-14 ko04713 Circadian entrainment 43/670 136/7206 1.54831516021e-13 ko04911 Insulin secretion 36/670 117/7206 3.7748441841e-11 ko04725 Cholinergic synapse 43/670 160/7206 6.67923427523e-11 ko04726 Serotonergic synapse 38/670 137/7206 3.26312843149e-10 ko04966 Collecting duct acid secretion 15/670 26/7206 8.42515445765e-10 ko05031 Amphetamine addiction 28/670 91/7206 5.85043558968e-09 ko04744 Phototransduction 16/670 36/7206 3.24356986887e-08 ko04024 cAMP signaling pathway 55/670 279/7206 4.42031764825e-08 ko04261 Adrenergic signaling in cardiomyocytes 44/670 205/7206 1.10458566632e-07 ko04921 Oxytocin signaling pathway 43/670 209/7206 4.00127101051e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 22/670 74/7206 4.95842906885e-07 ko05110 Vibrio cholerae infection 20/670 63/7206 5.08645650641e-07 ko05030 Cocaine addiction 21/670 73/7206 1.64151510929e-06 ko04010 MAPK signaling pathway 56/670 321/7206 2.7260216514e-06 ko04060 Cytokine-cytokine receptor interaction 2/670 191/7206 2.99694004848e-06 ko04970 Salivary secretion 24/670 95/7206 3.87991641665e-06 ko04742 Taste transduction 18/670 61/7206 6.11275939586e-06 ko05120 Epithelial cell signaling in Helicobacter pylori infection 23/670 92/7206 7.44862265198e-06 ko04720 Long-term potentiation 24/670 99/7206 8.38917524698e-06 ko03040 Spliceosome 1/670 145/7206 1.71392193825e-05 ko04514 Cell adhesion molecules (CAMs) 28/670 130/7206 1.9872180446e-05 ko04964 Proximal tubule bicarbonate reclamation 11/670 29/7206 2.99625410354e-05 ko04120 Ubiquitin mediated proteolysis 1/670 138/7206 3.90665595083e-05 ko05322 Systemic lupus erythematosus 2/670 151/7206 9.25396980791e-05 ko05164 Influenza A 3/670 167/7206 0.00012512098798 ko05162 Measles 1/670 120/7206 0.000185902132961 ko04730 Long-term depression 18/670 78/7206 0.000218546065897 ko05168 Herpes simplex infection 4/670 182/7206 0.000228628359337 ko04924 Renin secretion 19/670 86/7206 0.000269779899044 ko05203 Viral carcinogenesis 10/670 277/7206 0.000304954361949 ko04145 Phagosome 29/670 162/7206 0.000506653259186 ko05323 Rheumatoid arthritis 19/670 89/7206 0.000588680983081 ko04260 Cardiac muscle contraction 20/670 98/7206 0.000633695240323 ko04972 Pancreatic secretion 22/670 111/7206 0.000698281598925 ko04961 Endocrine and other factor-regulated calcium reabsorption 14/670 59/7206 0.00079943213255 ko04925 Aldosterone synthesis and secretion 20/670 105/7206 0.00179945452688 ko04971 Gastric acid secretion 19/670 98/7206 0.00221254767517 ko04020 Calcium signaling pathway 40/670 265/7206 0.00232754935678 ko03013 RNA transport 5/670 166/7206 0.00260961801811 ko04976 Bile secretion 16/670 80/7206 0.00283604498282 ko04978 Mineral absorption 10/670 40/7206 0.00290899762933 ko04510 Focal adhesion 10/670 240/7206 0.00316195717485 ko04022 cGMP-PKG signaling pathway 33/670 216/7206 0.00399758012175 ko04626 Plant-pathogen interaction 6/670 18/7206 0.00441879568481 ko04621 NOD-like receptor signaling pathway 5/670 157/7206 0.00494994751631 ko04350 TGF-beta signaling pathway 2/670 103/7206 0.00543753160087 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 15/670 79/7206 0.00594198639006 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/670 14/7206 0.00672274397689 ko04540 Gap junction 21/670 128/7206 0.0086001575879 ko04612 Antigen processing and presentation 1/670 77/7206 0.00899082890664 ko03008 Ribosome biogenesis in eukaryotes 1/670 79/7206 0.00945943457818 ko04740 Olfactory transduction 15/670 80/7206 0.00983670266564 ko05205 Proteoglycans in cancer 14/670 271/7206 0.0139791791215 ko04141 Protein processing in endoplasmic reticulum 8/670 184/7206 0.0144660787475 ko05016 Huntington's disease 10/670 215/7206 0.0163295661434 ko04932 Non-alcoholic fatty liver disease (NAFLD) 8/670 182/7206 0.0191431834544 ko04962 Vasopressin-regulated water reabsorption 11/670 58/7206 0.0198146561905 ko04745 Phototransduction - fly 8/670 38/7206 0.0212878993047 ko05166 HTLV-I infection 16/670 292/7206 0.0229266554806 ko04391 Hippo signaling pathway - fly 15/670 90/7206 0.0258108259277 ko00910 Nitrogen metabolism 5/670 19/7206 0.0264622969387 ko04330 Notch signaling pathway 1/670 62/7206 0.0276586598957 ko04064 NF-kappa B signaling pathway 3/670 96/7206 0.0325211937007 ko04360 Axon guidance 31/670 233/7206 0.0384356444034 ko04071 Sphingolipid signaling pathway 23/670 162/7206 0.0388236834446 ko00190 Oxidative phosphorylation 19/670 127/7206 0.0427932700328 ko01524 Platinum drug resistance 2/670 76/7206 0.0446419627819 ko04014 Ras signaling pathway 36/670 279/7206 0.0447823182619