ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 26/345 134/7206 6.26454325012e-10 ko04621 NOD-like receptor signaling pathway 26/345 157/7206 2.09387188748e-08 ko04060 Cytokine-cytokine receptor interaction 29/345 191/7206 2.36433672095e-08 ko05164 Influenza A 26/345 167/7206 7.71039190223e-08 ko04668 TNF signaling pathway 21/345 120/7206 1.8985758645e-07 ko04610 Complement and coagulation cascades 16/345 79/7206 7.35919468217e-07 ko05323 Rheumatoid arthritis 17/345 89/7206 7.94188298749e-07 ko04064 NF-kappa B signaling pathway 17/345 96/7206 2.4012271768e-06 ko04512 ECM-receptor interaction 15/345 79/7206 3.85658109777e-06 ko04620 Toll-like receptor signaling pathway 17/345 100/7206 4.29863576946e-06 ko04933 AGE-RAGE signaling pathway in diabetic complications 20/345 135/7206 5.58896465561e-06 ko04623 Cytosolic DNA-sensing pathway 10/345 41/7206 1.64673441315e-05 ko04660 T cell receptor signaling pathway 18/345 124/7206 2.19542422466e-05 ko04672 Intestinal immune network for IgA production 9/345 37/7206 4.49713123229e-05 ko04630 Jak-STAT signaling pathway 18/345 132/7206 5.1705269781e-05 ko05321 Inflammatory bowel disease (IBD) 11/345 56/7206 5.5194651946e-05 ko05133 Pertussis 14/345 87/7206 5.72039807543e-05 ko05340 Primary immunodeficiency 8/345 30/7206 5.8933903781e-05 ko05161 Hepatitis B 21/345 173/7206 7.22329884453e-05 ko04622 RIG-I-like receptor signaling pathway 11/345 62/7206 0.000145570345469 ko04658 Th1 and Th2 cell differentiation 14/345 96/7206 0.00017111464496 ko05162 Measles 16/345 120/7206 0.000175992694763 ko05140 Leishmaniasis 12/345 75/7206 0.000204315220087 ko05144 Malaria 9/345 45/7206 0.000228165829472 ko05150 Staphylococcus aureus infection 8/345 36/7206 0.00023681192926 ko04662 B cell receptor signaling pathway 13/345 88/7206 0.000255227635632 ko04670 Leukocyte transendothelial migration 18/345 151/7206 0.000296603630549 ko05145 Toxoplasmosis 16/345 126/7206 0.000311448786228 ko04659 Th17 cell differentiation 14/345 106/7206 0.000489726112067 ko05168 Herpes simplex infection 20/345 182/7206 0.000531917319659 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/345 191/7206 0.000847165623883 ko04510 Focal adhesion 23/345 240/7206 0.00167187804242 ko05131 Shigellosis 11/345 82/7206 0.00170364688172 ko00120 Primary bile acid biosynthesis 5/345 20/7206 0.00208727027185 ko04650 Natural killer cell mediated cytotoxicity 12/345 97/7206 0.00216550003314 ko04217 Necroptosis 18/345 178/7206 0.00222106725993 ko05152 Tuberculosis 19/345 187/7206 0.0024669697558 ko04210 Apoptosis 18/345 180/7206 0.00369302403327 ko05166 HTLV-I infection 25/345 292/7206 0.00456998702715 ko03013 RNA transport 1/345 166/7206 0.00491326780398 ko05142 Chagas disease (American trypanosomiasis) 14/345 130/7206 0.0051887980544 ko04137 Mitophagy - animal 10/345 82/7206 0.00549507253325 ko05160 Hepatitis C 15/345 153/7206 0.00685674689747 ko05132 Salmonella infection 11/345 98/7206 0.00690440874418 ko05146 Amoebiasis 11/345 99/7206 0.00744526674192 ko04611 Platelet activation 16/345 163/7206 0.0077205559911 ko04666 Fc gamma R-mediated phagocytosis 13/345 122/7206 0.00778393465283 ko05134 Legionellosis 9/345 74/7206 0.00841081409322 ko04724 Glutamatergic synapse 1/345 152/7206 0.0106720242227 ko04612 Antigen processing and presentation 9/345 77/7206 0.0108343731213 ko04726 Serotonergic synapse 1/345 137/7206 0.0148041390995 ko04114 Oocyte meiosis 1/345 139/7206 0.0148275088956 ko05212 Pancreatic cancer 9/345 83/7206 0.0172053128956 ko04144 Endocytosis 26/345 342/7206 0.0185800386846 ko04062 Chemokine signaling pathway 17/345 201/7206 0.0187393265061 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/345 5/7206 0.0207584109531 ko00281 Geraniol degradation 2/345 5/7206 0.0207584109531 ko04713 Circadian entrainment 1/345 136/7206 0.0225218074396 ko04550 Signaling pathways regulating pluripotency of stem cells 2/345 165/7206 0.0249502007447 ko05418 Fluid shear stress and atherosclerosis 15/345 173/7206 0.0276061955924 ko04540 Gap junction 1/345 128/7206 0.0326186460083 ko04932 Non-alcoholic fatty liver disease (NAFLD) 15/345 182/7206 0.034106312323 ko04141 Protein processing in endoplasmic reticulum 3/345 184/7206 0.0356156584263 ko04657 IL-17 signaling pathway 9/345 87/7206 0.0363926486839 ko04068 FoxO signaling pathway 14/345 167/7206 0.0404929724359 ko05120 Epithelial cell signaling in Helicobacter pylori infection 9/345 92/7206 0.0419896279997 ko04911 Insulin secretion 1/345 117/7206 0.0453876940803 ko05416 Viral myocarditis 6/345 55/7206 0.0464714834913 ko05320 Autoimmune thyroid disease 4/345 29/7206 0.0476568623327 ko00051 Fructose and mannose metabolism 5/345 42/7206 0.0486703879458