ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 59/282 423/7206 1.40649657974e-18 ko05033 Nicotine addiction 20/282 56/7206 8.03825112595e-15 ko04724 Glutamatergic synapse 30/282 152/7206 9.22961096481e-14 ko04723 Retrograde endocannabinoid signaling 29/282 175/7206 2.41209185368e-11 ko04020 Calcium signaling pathway 35/282 265/7206 1.42590863509e-10 ko05032 Morphine addiction 22/282 110/7206 1.64763735113e-10 ko04742 Taste transduction 16/282 61/7206 8.20939884151e-10 ko04727 GABAergic synapse 21/282 110/7206 1.07772665627e-09 ko04024 cAMP signaling pathway 32/282 279/7206 3.17368138419e-08 ko04921 Oxytocin signaling pathway 26/282 209/7206 1.33960599591e-07 ko04720 Long-term potentiation 17/282 99/7206 2.2265064648e-07 ko04072 Phospholipase D signaling pathway 24/282 197/7206 6.15136335832e-07 ko04728 Dopaminergic synapse 23/282 185/7206 7.41732064697e-07 ko04713 Circadian entrainment 19/282 136/7206 1.1972591181e-06 ko04261 Adrenergic signaling in cardiomyocytes 22/282 205/7206 1.48741368672e-05 ko04726 Serotonergic synapse 17/282 137/7206 2.21277654612e-05 ko04911 Insulin secretion 15/282 117/7206 4.59997044766e-05 ko05031 Amphetamine addiction 13/282 91/7206 4.73309174417e-05 ko04925 Aldosterone synthesis and secretion 14/282 105/7206 5.32076770879e-05 ko04721 Synaptic vesicle cycle 12/282 80/7206 5.67792481069e-05 ko04970 Salivary secretion 13/282 95/7206 7.48730417655e-05 ko04260 Cardiac muscle contraction 13/282 98/7206 0.000103788121003 ko05203 Viral carcinogenesis 1/282 277/7206 0.000359077706001 ko04070 Phosphatidylinositol signaling system 13/282 112/7206 0.000401971635135 ko04971 Gastric acid secretion 12/282 98/7206 0.000408500304849 ko04725 Cholinergic synapse 16/282 160/7206 0.000496349465661 ko04730 Long-term depression 10/282 78/7206 0.000856443307306 ko04022 cGMP-PKG signaling pathway 19/282 216/7206 0.00092160896016 ko04010 MAPK signaling pathway 25/282 321/7206 0.00095594104459 ko04930 Type II diabetes mellitus 8/282 54/7206 0.00108087211448 ko04972 Pancreatic secretion 12/282 111/7206 0.00126174371302 ko04540 Gap junction 13/282 128/7206 0.00143270160512 ko05030 Cocaine addiction 9/282 73/7206 0.00203917551388 ko04750 Inflammatory mediator regulation of TRP channels 12/282 122/7206 0.00283557933216 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 9/282 79/7206 0.00352509976078 ko05414 Dilated cardiomyopathy 11/282 112/7206 0.00424583477323 ko04710 Circadian rhythm 6/282 43/7206 0.00613148335643 ko00562 Inositol phosphate metabolism 9/282 89/7206 0.00775755182309 ko00680 Methane metabolism 5/282 34/7206 0.00970961734031 ko04012 ErbB signaling pathway 10/282 109/7206 0.0100436815505 ko05168 Herpes simplex infection 1/282 182/7206 0.0104795232322 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/282 14/7206 0.0156622239737 ko05410 Hypertrophic cardiomyopathy (HCM) 9/282 100/7206 0.0160205775921 ko04014 Ras signaling pathway 19/282 279/7206 0.0170401686214 ko04918 Thyroid hormone synthesis 8/282 86/7206 0.0188445492031 ko04978 Mineral absorption 5/282 40/7206 0.0189949718474 ko05231 Choline metabolism in cancer 11/282 134/7206 0.0201588121889 ko04960 Aldosterone-regulated sodium reabsorption 5/282 41/7206 0.0209627695142 ko00010 Glycolysis / Gluconeogenesis 7/282 74/7206 0.0250911842285 ko04964 Proximal tubule bicarbonate reclamation 4/282 29/7206 0.025221454372 ko04961 Endocrine and other factor-regulated calcium reabsorption 6/282 59/7206 0.0270083153487 ko04912 GnRH signaling pathway 10/282 122/7206 0.0282411412786 ko05322 Systemic lupus erythematosus 1/282 151/7206 0.0315027989442 ko04922 Glucagon signaling pathway 10/282 128/7206 0.033832943979 ko04060 Cytokine-cytokine receptor interaction 2/282 191/7206 0.0353082715723 ko04514 Cell adhesion molecules (CAMs) 10/282 130/7206 0.0361272264838 ko04740 Olfactory transduction 7/282 80/7206 0.0364166088837 ko04015 Rap1 signaling pathway 18/282 278/7206 0.0378700656838 ko05230 Central carbon metabolism in cancer 7/282 81/7206 0.0385851463925 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/282 1/7206 0.0391340549543