ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 32/499 191/7206 3.08983030972e-06 ko04380 Osteoclast differentiation 25/499 134/7206 4.03784776517e-06 ko04610 Complement and coagulation cascades 18/499 79/7206 5.14133259662e-06 ko04650 Natural killer cell mediated cytotoxicity 19/499 97/7206 2.86470338908e-05 ko00120 Primary bile acid biosynthesis 8/499 20/7206 2.99260271524e-05 ko05162 Measles 21/499 120/7206 6.42476427419e-05 ko05164 Influenza A 26/499 167/7206 7.75825411876e-05 ko04621 NOD-like receptor signaling pathway 25/499 157/7206 7.92730120175e-05 ko04064 NF-kappa B signaling pathway 18/499 96/7206 8.46309033523e-05 ko04710 Circadian rhythm 11/499 43/7206 0.000118246280929 ko03013 RNA transport 1/499 166/7206 0.000144425104282 ko04658 Th1 and Th2 cell differentiation 17/499 96/7206 0.000272792456315 ko00950 Isoquinoline alkaloid biosynthesis 5/499 10/7206 0.000293702561984 ko04659 Th17 cell differentiation 18/499 106/7206 0.000312383311671 ko05321 Inflammatory bowel disease (IBD) 12/499 56/7206 0.000357864725987 ko04660 T cell receptor signaling pathway 20/499 124/7206 0.000427003649219 ko00360 Phenylalanine metabolism 6/499 17/7206 0.000685018687 ko04110 Cell cycle 1/499 145/7206 0.000699184656587 ko04672 Intestinal immune network for IgA production 9/499 37/7206 0.000735549231609 ko05340 Primary immunodeficiency 8/499 30/7206 0.000749899871272 ko04662 B cell receptor signaling pathway 15/499 88/7206 0.000933020618682 ko05034 Alcoholism 5/499 238/7206 0.00106722584881 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/499 4/7206 0.00125260803128 ko00350 Tyrosine metabolism 8/499 33/7206 0.00147970887309 ko00051 Fructose and mannose metabolism 9/499 42/7206 0.00193390073763 ko04620 Toll-like receptor signaling pathway 16/499 100/7206 0.00201719431053 ko03010 Ribosome 1/499 129/7206 0.0022684928571 ko04630 Jak-STAT signaling pathway 19/499 132/7206 0.0025202942832 ko05168 Herpes simplex infection 24/499 182/7206 0.00259561025347 ko05150 Staphylococcus aureus infection 8/499 36/7206 0.0026840438333 ko04933 AGE-RAGE signaling pathway in diabetic complications 19/499 135/7206 0.00291062492909 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/499 5/7206 0.00297036177627 ko03040 Spliceosome 2/499 145/7206 0.00421400793582 ko04070 Phosphatidylinositol signaling system 16/499 112/7206 0.00453444396436 ko05160 Hepatitis C 20/499 153/7206 0.00544710322086 ko00140 Steroid hormone biosynthesis 8/499 41/7206 0.0062485224961 ko05145 Toxoplasmosis 17/499 126/7206 0.00701759709136 ko00592 alpha-Linolenic acid metabolism 5/499 19/7206 0.00804584984722 ko04670 Leukocyte transendothelial migration 19/499 151/7206 0.00926278637236 ko05323 Rheumatoid arthritis 13/499 89/7206 0.00948258948634 ko04668 TNF signaling pathway 16/499 120/7206 0.00998833494007 ko05144 Malaria 8/499 45/7206 0.0110593799768 ko04640 Hematopoietic cell lineage 10/499 64/7206 0.011854374485 ko05230 Central carbon metabolism in cancer 12/499 81/7206 0.0122547691129 ko05152 Tuberculosis 22/499 187/7206 0.0125576678848 ko04270 Vascular smooth muscle contraction 19/499 154/7206 0.0145040292574 ko04925 Aldosterone synthesis and secretion 14/499 105/7206 0.0175595024355 ko05140 Leishmaniasis 11/499 75/7206 0.0179900662787 ko04111 Cell cycle - yeast 1/499 90/7206 0.0203352643425 ko04922 Glucagon signaling pathway 16/499 128/7206 0.0203734170495 ko03015 mRNA surveillance pathway 1/499 93/7206 0.0209758384534 ko04072 Phospholipase D signaling pathway 22/499 197/7206 0.0224659407656 ko00052 Galactose metabolism 6/499 33/7206 0.0238726851392 ko00590 Arachidonic acid metabolism 8/499 52/7206 0.0253196259021 ko04120 Ubiquitin mediated proteolysis 3/499 138/7206 0.0256182359915 ko03320 PPAR signaling pathway 10/499 69/7206 0.0264639747213 ko04611 Platelet activation 19/499 163/7206 0.0268881397124 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/499 191/7206 0.0300424917757 ko05224 Breast cancer 5/499 174/7206 0.0327628007497 ko04622 RIG-I-like receptor signaling pathway 9/499 62/7206 0.0372877472813 ko00561 Glycerolipid metabolism 9/499 63/7206 0.0390187961187 ko00982 Drug metabolism - cytochrome P450 6/499 37/7206 0.0397381424792 ko04390 Hippo signaling pathway 6/499 188/7206 0.0404212865738 ko04745 Phototransduction - fly 6/499 38/7206 0.0445430252923 ko05320 Autoimmune thyroid disease 5/499 29/7206 0.0465503959606