ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	38/683	56/7206	2.05050728305e-26
ko04080	Neuroactive ligand-receptor interaction	110/683	423/7206	1.29406414454e-24
ko04724	Glutamatergic synapse	61/683	152/7206	1.64153680386e-24
ko04727	GABAergic synapse	43/683	110/7206	4.56062295954e-17
ko05032	Morphine addiction	42/683	110/7206	2.92522118211e-16
ko04721	Synaptic vesicle cycle	34/683	80/7206	4.82552225898e-15
ko04728	Dopaminergic synapse	54/683	185/7206	1.11150390019e-14
ko04723	Retrograde endocannabinoid signaling	49/683	175/7206	1.13986817486e-12
ko04713	Circadian entrainment	41/683	136/7206	6.28232507196e-12
ko04725	Cholinergic synapse	44/683	160/7206	3.28043257117e-11
ko04024	cAMP signaling pathway	61/683	279/7206	2.17849082548e-10
ko04911	Insulin secretion	34/683	117/7206	1.22915726308e-09
ko05030	Cocaine addiction	24/683	73/7206	2.47645053534e-08
ko04514	Cell adhesion molecules (CAMs)	33/683	130/7206	8.44751134998e-08
ko04360	Axon guidance	47/683	233/7206	5.20561591288e-07
ko04742	Taste transduction	19/683	61/7206	1.82222870022e-06
ko05031	Amphetamine addiction	24/683	91/7206	2.39045813581e-06
ko04261	Adrenergic signaling in cardiomyocytes	41/683	205/7206	2.78843111809e-06
ko04726	Serotonergic synapse	31/683	137/7206	4.1015140975e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	20/683	74/7206	1.10830726402e-05
ko04060	Cytokine-cytokine receptor interaction	3/683	191/7206	1.36761269791e-05
ko03040	Spliceosome	1/683	145/7206	1.82072536505e-05
ko05203	Viral carcinogenesis	8/683	277/7206	2.26061247879e-05
ko04010	MAPK signaling pathway	53/683	321/7206	5.25148138856e-05
ko04972	Pancreatic secretion	24/683	111/7206	0.000100778970401
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/683	79/7206	0.000105384590812
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/683	14/7206	0.000126167935096
ko05164	Influenza A	3/683	167/7206	0.000131588692064
ko05168	Herpes simplex infection	4/683	182/7206	0.000156105107455
ko04921	Oxytocin signaling pathway	37/683	209/7206	0.000164036791665
ko04120	Ubiquitin mediated proteolysis	2/683	138/7206	0.00019179015356
ko04621	NOD-like receptor signaling pathway	3/683	157/7206	0.000261626180054
ko04970	Salivary secretion	20/683	95/7206	0.000549762730603
ko03013	RNA transport	4/683	166/7206	0.000650213186208
ko04260	Cardiac muscle contraction	20/683	98/7206	0.00078019300298
ko05205	Proteoglycans in cancer	11/683	271/7206	0.000959392319813
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/683	59/7206	0.000967187919859
ko05169	Epstein-Barr virus infection	7/683	206/7206	0.00103875411586
ko04730	Long-term depression	17/683	78/7206	0.00122742192957
ko04720	Long-term potentiation	20/683	99/7206	0.00139273598793
ko05322	Systemic lupus erythematosus	4/683	151/7206	0.00174195301258
ko04141	Protein processing in endoplasmic reticulum	6/683	184/7206	0.00195443579025
ko04020	Calcium signaling pathway	40/683	265/7206	0.00263526553629
ko03018	RNA degradation	1/683	84/7206	0.00414694047173
ko04964	Proximal tubule bicarbonate reclamation	8/683	29/7206	0.00442455419665
ko03008	Ribosome biogenesis in eukaryotes	1/683	79/7206	0.00603497076923
ko04630	Jak-STAT signaling pathway	4/683	132/7206	0.00651365492568
ko04932	Non-alcoholic fatty liver disease (NAFLD)	7/683	182/7206	0.00656001918597
ko04140	Autophagy - animal	6/683	164/7206	0.00662395145994
ko04064	NF-kappa B signaling pathway	2/683	96/7206	0.00765999691359
ko04217	Necroptosis	7/683	178/7206	0.00885701848823
ko04072	Phospholipase D signaling pathway	30/683	197/7206	0.00899141105927
ko01200	Carbon metabolism	4/683	128/7206	0.00903022232553
ko04022	cGMP-PKG signaling pathway	32/683	216/7206	0.00929315340758
ko04014	Ras signaling pathway	39/683	279/7206	0.0120725255182
ko00240	Pyrimidine metabolism	3/683	110/7206	0.0124580593691
ko05414	Dilated cardiomyopathy	19/683	112/7206	0.0131947093919
ko04214	Apoptosis - fly	1/683	72/7206	0.0132542462519
ko04930	Type II diabetes mellitus	11/683	54/7206	0.0156411854017
ko00512	Mucin type O-glycan biosynthesis	7/683	29/7206	0.0163014907206
ko04350	TGF-beta signaling pathway	3/683	103/7206	0.016777040209
ko05162	Measles	4/683	120/7206	0.0172425838296
ko04976	Bile secretion	14/683	80/7206	0.0202731297435
ko04110	Cell cycle	6/683	145/7206	0.0216643449745
ko04137	Mitophagy - animal	2/683	82/7206	0.0220381052923
ko05161	Hepatitis B	8/683	173/7206	0.0248449537731
ko00515	Mannose type O-glycan biosynthesis	6/683	25/7206	0.026231788779
ko00330	Arginine and proline metabolism	1/683	61/7206	0.0275110145125
ko04391	Hippo signaling pathway - fly	15/683	90/7206	0.0278692720228
ko00561	Glycerolipid metabolism	1/683	63/7206	0.0279730169405
ko04071	Sphingolipid signaling pathway	24/683	162/7206	0.0285439669287
ko04640	Hematopoietic cell lineage	1/683	64/7206	0.0285961285926
ko05145	Toxoplasmosis	5/683	126/7206	0.03069056113
ko04612	Antigen processing and presentation	2/683	77/7206	0.0312143422084
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/683	26/7206	0.0314574953948
ko05215	Prostate cancer	4/683	111/7206	0.0321714641173
ko04138	Autophagy - yeast	2/683	81/7206	0.0327326496254
ko00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/683	8/7206	0.0330253720678
ko04915	Estrogen signaling pathway	20/683	131/7206	0.033226147002
ko05410	Hypertrophic cardiomyopathy (HCM)	16/683	100/7206	0.0366568254915
ko04924	Renin secretion	14/683	86/7206	0.039765642477
ko01212	Fatty acid metabolism	1/683	60/7206	0.0418995249283
ko00310	Lysine degradation	2/683	73/7206	0.0440380811428
ko00010	Glycolysis / Gluconeogenesis	2/683	74/7206	0.0442216775631
ko04146	Peroxisome	3/683	89/7206	0.0445937471317
ko05140	Leishmaniasis	2/683	75/7206	0.0447056334563
ko01524	Platinum drug resistance	2/683	76/7206	0.0454887377262
ko04540	Gap junction	19/683	128/7206	0.0462240993422
ko02024	Quorum sensing	4/683	15/7206	0.0468489329744
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/683	15/7206	0.0468489329744
ko05418	Fluid shear stress and atherosclerosis	9/683	173/7206	0.0490001155964
ko04218	Cellular senescence	9/683	177/7206	0.0497795681774