ko pathway ratio_in_study ratio_in_pop p_value ko04710 Circadian rhythm 13/319 43/7206 2.16351942339e-08 ko00010 Glycolysis / Gluconeogenesis 13/319 74/7206 1.7858454694e-05 ko04724 Glutamatergic synapse 17/319 152/7206 0.000372477163557 ko04921 Oxytocin signaling pathway 21/319 209/7206 0.000419464937704 ko04922 Glucagon signaling pathway 15/319 128/7206 0.00049731307773 ko00680 Methane metabolism 7/319 34/7206 0.000596823963166 ko04725 Cholinergic synapse 17/319 160/7206 0.000677674354291 ko04713 Circadian entrainment 15/319 136/7206 0.000944472980098 ko04070 Phosphatidylinositol signaling system 13/319 112/7206 0.00127475982344 ko02010 ABC transporters 7/319 39/7206 0.0014110695906 ko04020 Calcium signaling pathway 23/319 265/7206 0.00192469334229 ko00051 Fructose and mannose metabolism 7/319 42/7206 0.00220901278728 ko04726 Serotonergic synapse 14/319 137/7206 0.00286102104524 ko04068 FoxO signaling pathway 16/319 167/7206 0.00333482153445 ko04022 cGMP-PKG signaling pathway 19/319 216/7206 0.00374905824471 ko01230 Biosynthesis of amino acids 10/319 85/7206 0.00410639427591 ko04270 Vascular smooth muscle contraction 15/319 154/7206 0.00414048702718 ko04611 Platelet activation 15/319 163/7206 0.00615361339974 ko00230 Purine metabolism 17/319 194/7206 0.00676695541716 ko04014 Ras signaling pathway 22/319 279/7206 0.00721076410293 ko04730 Long-term depression 9/319 78/7206 0.00721248828566 ko04514 Cell adhesion molecules (CAMs) 13/319 130/7206 0.00744161744982 ko05032 Morphine addiction 11/319 110/7206 0.00917189012562 ko04138 Autophagy - yeast 9/319 81/7206 0.00919442202255 ko04930 Type II diabetes mellitus 7/319 54/7206 0.00922458673528 ko00120 Primary bile acid biosynthesis 4/319 20/7206 0.010401563432 ko00564 Glycerophospholipid metabolism 10/319 99/7206 0.0118801691748 ko00030 Pentose phosphate pathway 5/319 32/7206 0.012397438148 ko04213 Longevity regulating pathway - multiple species 9/319 86/7206 0.013378964707 ko04371 Apelin signaling pathway 15/319 177/7206 0.0144438649631 ko05322 Systemic lupus erythematosus 1/319 151/7206 0.0149710035879 ko04152 AMPK signaling pathway 14/319 161/7206 0.0171907600887 ko04711 Circadian rhythm - fly 3/319 13/7206 0.0176566579909 ko04911 Insulin secretion 11/319 117/7206 0.0190018900382 ko04072 Phospholipase D signaling pathway 16/319 197/7206 0.0200416544714 ko03040 Spliceosome 1/319 145/7206 0.0221099284318 ko04110 Cell cycle 1/319 145/7206 0.0221099284318 ko04750 Inflammatory mediator regulation of TRP channels 11/319 122/7206 0.0227365409851 ko04066 HIF-1 signaling pathway 11/319 123/7206 0.0236341990234 ko04925 Aldosterone synthesis and secretion 10/319 105/7206 0.0257670196897 ko04137 Mitophagy - animal 8/319 82/7206 0.028016229703 ko01200 Carbon metabolism 11/319 128/7206 0.0289105118446 ko04727 GABAergic synapse 10/319 110/7206 0.030012668343 ko04970 Salivary secretion 9/319 95/7206 0.0374038294314 ko04971 Gastric acid secretion 9/319 98/7206 0.0404333479517 ko04720 Long-term potentiation 9/319 99/7206 0.0416270745727 ko05340 Primary immunodeficiency 4/319 30/7206 0.0416742560632 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/319 1/7206 0.0442686650015 ko04136 Autophagy - other 4/319 31/7206 0.0462417961489 ko03010 Ribosome 1/319 129/7206 0.0468960852264 ko00592 alpha-Linolenic acid metabolism 3/319 19/7206 0.049226023472