ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 113/797 423/7206 1.75258230805e-20 ko04724 Glutamatergic synapse 52/797 152/7206 1.43066293242e-14 ko04024 cAMP signaling pathway 76/797 279/7206 1.89348371106e-14 ko04020 Calcium signaling pathway 71/797 265/7206 3.20079297855e-13 ko05032 Morphine addiction 40/797 110/7206 1.8313095193e-12 ko04713 Circadian entrainment 44/797 136/7206 1.42199492706e-11 ko04070 Phosphatidylinositol signaling system 38/797 112/7206 7.37407308441e-11 ko05033 Nicotine addiction 24/797 56/7206 1.09678941167e-09 ko04921 Oxytocin signaling pathway 54/797 209/7206 1.47365159965e-09 ko04727 GABAergic synapse 35/797 110/7206 2.98375874473e-09 ko04911 Insulin secretion 36/797 117/7206 4.89912446389e-09 ko04725 Cholinergic synapse 42/797 160/7206 5.37043237812e-08 ko04925 Aldosterone synthesis and secretion 31/797 105/7206 1.65627202343e-07 ko04970 Salivary secretion 29/797 95/7206 1.87762275857e-07 ko04723 Retrograde endocannabinoid signaling 43/797 175/7206 2.77930943873e-07 ko04728 Dopaminergic synapse 44/797 185/7206 5.83550422538e-07 ko05031 Amphetamine addiction 27/797 91/7206 9.32716249171e-07 ko04726 Serotonergic synapse 35/797 137/7206 1.36500635108e-06 ko04072 Phospholipase D signaling pathway 45/797 197/7206 1.4352195718e-06 ko04720 Long-term potentiation 28/797 99/7206 1.71121247535e-06 ko04261 Adrenergic signaling in cardiomyocytes 46/797 205/7206 2.17471534167e-06 ko04721 Synaptic vesicle cycle 24/797 80/7206 3.01601625759e-06 ko04022 cGMP-PKG signaling pathway 47/797 216/7206 4.13141664282e-06 ko04710 Circadian rhythm 16/797 43/7206 6.39652195052e-06 ko03010 Ribosome 1/797 129/7206 6.55966192499e-06 ko03040 Spliceosome 2/797 145/7206 1.16937330506e-05 ko05322 Systemic lupus erythematosus 3/797 151/7206 3.64571534163e-05 ko03013 RNA transport 4/797 166/7206 4.71222065375e-05 ko04730 Long-term depression 21/797 78/7206 7.46949169911e-05 ko05030 Cocaine addiction 20/797 73/7206 8.44725237823e-05 ko00562 Inositol phosphate metabolism 23/797 89/7206 9.67485093175e-05 ko04010 MAPK signaling pathway 58/797 321/7206 0.000119230532033 ko04742 Taste transduction 17/797 61/7206 0.000226493839641 ko04744 Phototransduction 12/797 36/7206 0.000310584965057 ko04922 Glucagon signaling pathway 28/797 128/7206 0.000315936024391 ko05231 Choline metabolism in cancer 29/797 134/7206 0.000387227545559 ko04110 Cell cycle 4/797 145/7206 0.000407018026186 ko04923 Regulation of lipolysis in adipocytes 19/797 77/7206 0.000662065400647 ko04750 Inflammatory mediator regulation of TRP channels 26/797 122/7206 0.0010866862517 ko04745 Phototransduction - fly 11/797 38/7206 0.00204462978959 ko04971 Gastric acid secretion 21/797 98/7206 0.00287558070287 ko04972 Pancreatic secretion 23/797 111/7206 0.00316225318092 ko05203 Viral carcinogenesis 16/797 277/7206 0.00318768292779 ko04014 Ras signaling pathway 46/797 279/7206 0.00466565423473 ko04966 Collecting duct acid secretion 8/797 26/7206 0.00547810342414 ko05168 Herpes simplex infection 9/797 182/7206 0.00555250898097 ko04930 Type II diabetes mellitus 13/797 54/7206 0.00673197404704 ko04924 Renin secretion 18/797 86/7206 0.00810809139846 ko00564 Glycerophospholipid metabolism 20/797 99/7206 0.00864399468454 ko04540 Gap junction 24/797 128/7206 0.00959053232049 ko00680 Methane metabolism 9/797 34/7206 0.00968110496579 ko05230 Central carbon metabolism in cancer 17/797 81/7206 0.0109678752516 ko04141 Protein processing in endoplasmic reticulum 10/797 184/7206 0.0118418800358 ko05169 Epstein-Barr virus infection 12/797 206/7206 0.0127545833354 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/797 14/7206 0.0139402237799 ko05414 Dilated cardiomyopathy 21/797 112/7206 0.0141571317991 ko04371 Apelin signaling pathway 30/797 177/7206 0.0150175918947 ko04612 Antigen processing and presentation 2/797 77/7206 0.0155294402974 ko04912 GnRH signaling pathway 22/797 122/7206 0.0189803035242 ko04666 Fc gamma R-mediated phagocytosis 22/797 122/7206 0.0189803035242 ko00051 Fructose and mannose metabolism 10/797 42/7206 0.0213267277923 ko00010 Glycolysis / Gluconeogenesis 15/797 74/7206 0.0227310834438 ko04657 IL-17 signaling pathway 3/797 87/7206 0.0232432610086 ko05133 Pertussis 3/797 87/7206 0.0232432610086 ko05110 Vibrio cholerae infection 13/797 63/7206 0.0239616651741 ko00520 Amino sugar and nucleotide sugar metabolism 1/797 55/7206 0.0274490382383 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 15/797 79/7206 0.0301679908658 ko05217 Basal cell carcinoma 2/797 68/7206 0.0303222001504 ko03015 mRNA surveillance pathway 4/797 93/7206 0.0306268319484 ko05131 Shigellosis 3/797 82/7206 0.0315002904212 ko04260 Cardiac muscle contraction 18/797 98/7206 0.0327845956652 ko02010 ABC transporters 9/797 39/7206 0.0339337936382 ko01230 Biosynthesis of amino acids 16/797 85/7206 0.0342515130067 ko05410 Hypertrophic cardiomyopathy (HCM) 18/797 100/7206 0.0352101897724 ko04213 Longevity regulating pathway - multiple species 16/797 86/7206 0.035695163283 ko04350 TGF-beta signaling pathway 5/797 103/7206 0.0395103194769 ko04960 Aldosterone-regulated sodium reabsorption 9/797 41/7206 0.0402130354237 ko04626 Plant-pathogen interaction 5/797 18/7206 0.0411445067661 ko05130 Pathogenic Escherichia coli infection 3/797 77/7206 0.0430678014847 ko00513 Various types of N-glycan biosynthesis 9/797 42/7206 0.0442216423627 ko04711 Circadian rhythm - fly 4/797 13/7206 0.0470141058552 ko04270 Vascular smooth muscle contraction 25/797 154/7206 0.0499603794862