ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 31/261 152/7206 1.5000892001e-15 ko04713 Circadian entrainment 29/261 136/7206 3.78091371889e-15 ko05033 Nicotine addiction 19/261 56/7206 2.77946674455e-14 ko04080 Neuroactive ligand-receptor interaction 50/261 423/7206 3.15229581144e-14 ko04728 Dopaminergic synapse 32/261 185/7206 6.95272099589e-14 ko04727 GABAergic synapse 23/261 110/7206 4.77484964911e-12 ko05032 Morphine addiction 23/261 110/7206 4.77484964911e-12 ko04723 Retrograde endocannabinoid signaling 27/261 175/7206 1.11688106074e-10 ko04721 Synaptic vesicle cycle 18/261 80/7206 3.04010675119e-10 ko05031 Amphetamine addiction 19/261 91/7206 3.79756906433e-10 ko04024 cAMP signaling pathway 32/261 279/7206 4.74457608551e-09 ko04911 Insulin secretion 20/261 117/7206 5.30596714913e-09 ko05014 Amyotrophic lateral sclerosis (ALS) 16/261 74/7206 5.66422813282e-09 ko04725 Cholinergic synapse 22/261 160/7206 5.64363445945e-08 ko04720 Long-term potentiation 17/261 99/7206 7.24186060222e-08 ko04726 Serotonergic synapse 20/261 137/7206 8.45565690002e-08 ko04921 Oxytocin signaling pathway 25/261 209/7206 1.13634883671e-07 ko04966 Collecting duct acid secretion 8/261 26/7206 2.35755145541e-06 ko04971 Gastric acid secretion 14/261 98/7206 1.00815853704e-05 ko05030 Cocaine addiction 12/261 73/7206 1.01483788045e-05 ko05110 Vibrio cholerae infection 11/261 63/7206 1.31734511074e-05 ko04261 Adrenergic signaling in cardiomyocytes 21/261 205/7206 1.4728614289e-05 ko04626 Plant-pathogen interaction 6/261 18/7206 2.74124398723e-05 ko04970 Salivary secretion 13/261 95/7206 3.35792821658e-05 ko04745 Phototransduction - fly 8/261 38/7206 5.05627414962e-05 ko04742 Taste transduction 10/261 61/7206 5.76564609151e-05 ko04730 Long-term depression 11/261 78/7206 0.000102815705719 ko05120 Epithelial cell signaling in Helicobacter pylori infection 12/261 92/7206 0.000108556149811 ko04145 Phagosome 16/261 162/7206 0.000240053071997 ko04924 Renin secretion 11/261 86/7206 0.000250269164736 ko05010 Alzheimer's disease 18/261 202/7206 0.000359594225171 ko04925 Aldosterone synthesis and secretion 12/261 105/7206 0.000384449470597 ko04114 Oocyte meiosis 14/261 139/7206 0.000479864129698 ko05034 Alcoholism 20/261 238/7206 0.000503230695235 ko04972 Pancreatic secretion 12/261 111/7206 0.000640773100888 ko00190 Oxidative phosphorylation 13/261 127/7206 0.000651695699976 ko04360 Axon guidance 19/261 233/7206 0.000912174354729 ko05323 Rheumatoid arthritis 10/261 89/7206 0.00133435346307 ko04750 Inflammatory mediator regulation of TRP channels 12/261 122/7206 0.00148255383173 ko04540 Gap junction 12/261 128/7206 0.00223666455157 ko04015 Rap1 signaling pathway 20/261 278/7206 0.00288127690848 ko04964 Proximal tubule bicarbonate reclamation 5/261 29/7206 0.0034891017941 ko04020 Calcium signaling pathway 19/261 265/7206 0.00389570656001 ko04961 Endocrine and other factor-regulated calcium reabsorption 7/261 59/7206 0.00514561842151 ko04922 Glucagon signaling pathway 11/261 128/7206 0.00653516038235 ko04014 Ras signaling pathway 19/261 279/7206 0.00782551089225 ko04740 Olfactory transduction 8/261 80/7206 0.00809109537832 ko05152 Tuberculosis 14/261 187/7206 0.00869982215264 ko04260 Cardiac muscle contraction 9/261 98/7206 0.00882806621509 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 3/261 15/7206 0.0154706103494 ko04960 Aldosterone-regulated sodium reabsorption 5/261 41/7206 0.0154881076063 ko04916 Melanogenesis 11/261 142/7206 0.0187873084042 ko05214 Glioma 7/261 79/7206 0.0238030959482 ko04940 Type I diabetes mellitus 4/261 32/7206 0.0272551281818 ko04915 Estrogen signaling pathway 10/261 131/7206 0.0277982419504 ko04550 Signaling pathways regulating pluripotency of stem cells 1/261 165/7206 0.0319352335202 ko00680 Methane metabolism 4/261 34/7206 0.033239758256 ko04016 MAPK signaling pathway - plant 3/261 20/7206 0.0339459205089 ko04918 Thyroid hormone synthesis 7/261 86/7206 0.0357318721545 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/261 1/7206 0.0362198168194 ko04371 Apelin signaling pathway 12/261 177/7206 0.0373094860931 ko04022 cGMP-PKG signaling pathway 14/261 216/7206 0.0383236367286 ko04744 Phototransduction 4/261 36/7206 0.0399321142761 ko04912 GnRH signaling pathway 9/261 122/7206 0.043190917458 ko05322 Systemic lupus erythematosus 1/261 151/7206 0.045255361397 ko04621 NOD-like receptor signaling pathway 1/261 157/7206 0.0470484122449