ko pathway ratio_in_study ratio_in_pop p_value ko04621 NOD-like receptor signaling pathway 22/221 157/7206 1.81142530238e-09 ko04217 Necroptosis 21/221 178/7206 9.51383838346e-08 ko05164 Influenza A 20/221 167/7206 1.52264364679e-07 ko04060 Cytokine-cytokine receptor interaction 21/221 191/7206 3.20118522149e-07 ko04210 Apoptosis 20/221 180/7206 5.23084597334e-07 ko04380 Osteoclast differentiation 17/221 134/7206 5.94714915029e-07 ko00643 Styrene degradation 4/221 4/7206 8.61589110006e-07 ko04657 IL-17 signaling pathway 13/221 87/7206 2.04926273374e-06 ko04668 TNF signaling pathway 15/221 120/7206 3.37844390139e-06 ko00350 Tyrosine metabolism 8/221 33/7206 4.93764086438e-06 ko05133 Pertussis 12/221 87/7206 1.19546051661e-05 ko00140 Steroid hormone biosynthesis 8/221 41/7206 2.74944542764e-05 ko04620 Toll-like receptor signaling pathway 12/221 100/7206 4.98157836263e-05 ko05204 Chemical carcinogenesis 8/221 48/7206 9.02508484799e-05 ko04622 RIG-I-like receptor signaling pathway 9/221 62/7206 0.00010054087437 ko05145 Toxoplasmosis 13/221 126/7206 0.000118762580718 ko04064 NF-kappa B signaling pathway 11/221 96/7206 0.000156763170408 ko00980 Metabolism of xenobiotics by cytochrome P450 7/221 40/7206 0.000182506867579 ko05160 Hepatitis C 14/221 153/7206 0.00023645012188 ko05418 Fluid shear stress and atherosclerosis 15/221 173/7206 0.000257427244561 ko05161 Hepatitis B 15/221 173/7206 0.000257427244561 ko04080 Neuroactive ligand-receptor interaction 2/221 423/7206 0.000358365505883 ko05134 Legionellosis 9/221 74/7206 0.000398233192385 ko01524 Platinum drug resistance 9/221 76/7206 0.000486807943663 ko04624 Toll and Imd signaling pathway 7/221 49/7206 0.000665364098167 ko05168 Herpes simplex infection 14/221 182/7206 0.0013536640132 ko04623 Cytosolic DNA-sensing pathway 6/221 41/7206 0.00142309814228 ko00360 Phenylalanine metabolism 4/221 17/7206 0.00149590524556 ko05152 Tuberculosis 14/221 187/7206 0.00175262578686 ko05142 Chagas disease (American trypanosomiasis) 11/221 130/7206 0.00207652436435 ko04215 Apoptosis - multiple species 6/221 47/7206 0.00291713107562 ko00982 Drug metabolism - cytochrome P450 5/221 37/7206 0.00507593885327 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/221 4/7206 0.0053935680771 ko00480 Glutathione metabolism 6/221 55/7206 0.00643017119593 ko04142 Lysosome 11/221 151/7206 0.00655267100499 ko04630 Jak-STAT signaling pathway 10/221 132/7206 0.00717233507855 ko04115 p53 signaling pathway 7/221 74/7206 0.0073083194788 ko05167 Kaposi's sarcoma-associated herpesvirus infection 13/221 191/7206 0.00814112422746 ko00830 Retinol metabolism 5/221 42/7206 0.00875431690465 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/221 5/7206 0.0088080054404 ko05131 Shigellosis 7/221 82/7206 0.0125775107939 ko04917 Prolactin signaling pathway 7/221 87/7206 0.0170141817913 ko04662 B cell receptor signaling pathway 7/221 88/7206 0.0180191405635 ko00120 Primary bile acid biosynthesis 3/221 20/7206 0.0220687291144 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/221 92/7206 0.0224578006523 ko00740 Riboflavin metabolism 2/221 8/7206 0.0232075371886 ko04930 Type II diabetes mellitus 5/221 54/7206 0.0242426101596 ko00520 Amino sugar and nucleotide sugar metabolism 5/221 55/7206 0.0260238540561 ko05140 Leishmaniasis 6/221 75/7206 0.0270207911927 ko04932 Non-alcoholic fatty liver disease (NAFLD) 11/221 182/7206 0.0271826876093 ko05132 Salmonella infection 7/221 98/7206 0.0304525304588 ko00401 Novobiocin biosynthesis 1/221 1/7206 0.0306688870386 ko05162 Measles 8/221 120/7206 0.0307688403079 ko05146 Amoebiasis 7/221 99/7206 0.0319494915233 ko04062 Chemokine signaling pathway 12/221 201/7206 0.0336820985293 ko05034 Alcoholism 2/221 238/7206 0.0351435903512 ko00950 Isoquinoline alkaloid biosynthesis 2/221 10/7206 0.0358255673108 ko04931 Insulin resistance 9/221 137/7206 0.0380935049836 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 2/221 11/7206 0.0429173100014 ko04723 Retrograde endocannabinoid signaling 1/221 175/7206 0.0452822425031