ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	103/989	145/7206	2.75680802423e-57
ko04110	Cell cycle	78/989	145/7206	7.96563966139e-31
ko03013	RNA transport	81/989	166/7206	4.16547724427e-28
ko05322	Systemic lupus erythematosus	76/989	151/7206	1.5245812717e-27
ko03030	DNA replication	33/989	38/7206	5.43057492174e-24
ko03460	Fanconi anemia pathway	38/989	51/7206	7.09551230111e-23
ko04111	Cell cycle - yeast	51/989	90/7206	7.19297916991e-22
ko03440	Homologous recombination	32/989	41/7206	1.63273844632e-20
ko03008	Ribosome biogenesis in eukaryotes	46/989	79/7206	1.65340131073e-20
ko05203	Viral carcinogenesis	91/989	277/7206	1.09931486594e-16
ko05034	Alcoholism	82/989	238/7206	1.2103021779e-16
ko04113	Meiosis - yeast	38/989	70/7206	9.32931550036e-16
ko03022	Basal transcription factors	28/989	44/7206	2.3106371055e-14
ko04020	Calcium signaling pathway	3/989	265/7206	1.10643137e-13
ko03420	Nucleotide excision repair	28/989	46/7206	1.18542641749e-13
ko03018	RNA degradation	39/989	84/7206	3.19190069355e-13
ko03430	Mismatch repair	18/989	22/7206	1.10436748879e-12
ko00240	Pyrimidine metabolism	43/989	110/7206	2.48328168677e-11
ko04144	Endocytosis	12/989	342/7206	1.58287395531e-10
ko03410	Base excision repair	22/989	38/7206	2.1255012206e-10
ko04060	Cytokine-cytokine receptor interaction	2/989	191/7206	3.38073776279e-10
ko03020	RNA polymerase	18/989	29/7206	2.00706946635e-09
ko03015	mRNA surveillance pathway	35/989	93/7206	5.9318551634e-09
ko05010	Alzheimer's disease	5/989	202/7206	5.98403734661e-08
ko04932	Non-alcoholic fatty liver disease (NAFLD)	4/989	182/7206	8.62971155114e-08
ko04723	Retrograde endocannabinoid signaling	4/989	175/7206	2.87874882185e-07
ko00190	Oxidative phosphorylation	1/989	127/7206	2.92603466254e-07
ko04724	Glutamatergic synapse	3/989	152/7206	6.01635756126e-07
ko04024	cAMP signaling pathway	13/989	279/7206	7.59612835621e-07
ko04022	cGMP-PKG signaling pathway	8/989	216/7206	9.98810727668e-07
ko03010	Ribosome	2/989	129/7206	1.8254373534e-06
ko04514	Cell adhesion molecules (CAMs)	2/989	130/7206	1.87498881866e-06
ko05012	Parkinson's disease	4/989	155/7206	2.74846260159e-06
ko04270	Vascular smooth muscle contraction	4/989	154/7206	4.1772524628e-06
ko04921	Oxytocin signaling pathway	9/989	209/7206	8.83865338483e-06
ko04151	PI3K-Akt signaling pathway	26/989	390/7206	9.75914031497e-06
ko04621	NOD-like receptor signaling pathway	5/989	157/7206	1.07952938801e-05
ko04261	Adrenergic signaling in cardiomyocytes	9/989	205/7206	1.23923142427e-05
ko04260	Cardiac muscle contraction	1/989	98/7206	1.86939199373e-05
ko04725	Cholinergic synapse	6/989	160/7206	3.71043180598e-05
ko04380	Osteoclast differentiation	4/989	134/7206	3.77933256353e-05
ko03450	Non-homologous end-joining	9/989	15/7206	3.83509997831e-05
ko04713	Circadian entrainment	4/989	136/7206	3.94279971128e-05
ko04015	Rap1 signaling pathway	17/989	278/7206	5.55547027166e-05
ko04911	Insulin secretion	3/989	117/7206	6.21250157864e-05
ko04920	Adipocytokine signaling pathway	1/989	89/7206	6.30260777995e-05
ko04062	Chemokine signaling pathway	10/989	201/7206	6.64333699903e-05
ko05146	Amoebiasis	2/989	99/7206	9.5927359471e-05
ko05410	Hypertrophic cardiomyopathy (HCM)	2/989	100/7206	9.74876403691e-05
ko04620	Toll-like receptor signaling pathway	2/989	100/7206	9.74876403691e-05
ko05145	Toxoplasmosis	4/989	126/7206	0.000114978189615
ko04010	MAPK signaling pathway	22/989	321/7206	0.000120490519484
ko04014	Ras signaling pathway	18/989	279/7206	0.000122910760825
ko04728	Dopaminergic synapse	9/989	185/7206	0.00012567786553
ko04727	GABAergic synapse	3/989	110/7206	0.00013195727119
ko04726	Serotonergic synapse	5/989	137/7206	0.00013401416376
ko05414	Dilated cardiomyopathy	3/989	112/7206	0.00013516424752
ko04721	Synaptic vesicle cycle	1/989	80/7206	0.000211575020029
ko04970	Salivary secretion	2/989	95/7206	0.000220755538433
ko04510	Focal adhesion	15/989	240/7206	0.000262619684724
ko05142	Chagas disease (American trypanosomiasis)	5/989	130/7206	0.000268710280119
ko04915	Estrogen signaling pathway	5/989	131/7206	0.000270920234928
ko05140	Leishmaniasis	1/989	75/7206	0.000300972703329
ko04611	Platelet activation	8/989	163/7206	0.000320604867462
ko04146	Peroxisome	2/989	89/7206	0.000477021204041
ko04971	Gastric acid secretion	3/989	98/7206	0.000583380927521
ko04120	Ubiquitin mediated proteolysis	34/989	138/7206	0.000617511670973
ko05168	Herpes simplex infection	42/989	182/7206	0.000625536668253
ko05169	Epstein-Barr virus infection	46/989	206/7206	0.000632014087794
ko04114	Oocyte meiosis	34/989	139/7206	0.000649990140161
ko05166	HTLV-I infection	61/989	292/7206	0.000652944567574
ko05032	Morphine addiction	4/989	110/7206	0.000685366419468
ko04972	Pancreatic secretion	4/989	111/7206	0.000696275680364
ko04072	Phospholipase D signaling pathway	12/989	197/7206	0.000738277408087
ko04912	GnRH signaling pathway	5/989	122/7206	0.00076673370454
ko04750	Inflammatory mediator regulation of TRP channels	5/989	122/7206	0.00076673370454
ko05152	Tuberculosis	11/989	187/7206	0.000773282226954
ko04659	Th17 cell differentiation	4/989	106/7206	0.000976675321542
ko04810	Regulation of actin cytoskeleton	19/989	264/7206	0.000982372650993
ko04668	TNF signaling pathway	5/989	120/7206	0.00111063977397
ko04142	Lysosome	8/989	151/7206	0.00114077199157
ko04360	Axon guidance	16/989	233/7206	0.00129886973556
ko00230	Purine metabolism	43/989	194/7206	0.0013626687542
ko04976	Bile secretion	2/989	80/7206	0.00149884718133
ko04740	Olfactory transduction	2/989	80/7206	0.00149884718133
ko04640	Hematopoietic cell lineage	1/989	64/7206	0.0015214829494
ko04152	AMPK signaling pathway	9/989	161/7206	0.00156948612226
ko04931	Insulin resistance	7/989	137/7206	0.00157211156689
ko04371	Apelin signaling pathway	11/989	177/7206	0.00185511639958
ko01212	Fatty acid metabolism	1/989	60/7206	0.00225897071281
ko04742	Taste transduction	1/989	61/7206	0.00226985329959
ko04924	Renin secretion	3/989	86/7206	0.00249736885446
ko05133	Pertussis	3/989	87/7206	0.00251305746566
ko04662	B cell receptor signaling pathway	3/989	88/7206	0.00257545633972
ko04218	Cellular senescence	39/989	177/7206	0.00258178604388
ko05160	Hepatitis C	9/989	153/7206	0.00276902691194
ko00564	Glycerophospholipid metabolism	4/989	99/7206	0.00282980704378
ko00010	Glycolysis / Gluconeogenesis	2/989	74/7206	0.00318834281199
ko04961	Endocrine and other factor-regulated calcium reabsorption	1/989	59/7206	0.00348464467822
ko01200	Carbon metabolism	7/989	128/7206	0.00402936854714
ko04925	Aldosterone synthesis and secretion	5/989	105/7206	0.00405317329135
ko04930	Type II diabetes mellitus	1/989	54/7206	0.00501561496699
ko05321	Inflammatory bowel disease (IBD)	1/989	56/7206	0.00518000491287
ko04933	AGE-RAGE signaling pathway in diabetic complications	8/989	135/7206	0.00523038713071
ko04660	T cell receptor signaling pathway	7/989	124/7206	0.00545184412401
ko05031	Amphetamine addiction	4/989	91/7206	0.00547060063639
ko04630	Jak-STAT signaling pathway	8/989	132/7206	0.00702733484727
ko05231	Choline metabolism in cancer	8/989	134/7206	0.00720807534832
ko04923	Regulation of lipolysis in adipocytes	3/989	77/7206	0.00724543296957
ko04730	Long-term depression	3/989	78/7206	0.00731249478945
ko04066	HIF-1 signaling pathway	7/989	123/7206	0.00756728911901
ko04670	Leukocyte transendothelial migration	10/989	151/7206	0.00817239079876
ko04712	Circadian rhythm - plant	4/989	7/7206	0.00874249773502
ko04330	Notch signaling pathway	16/989	62/7206	0.00911266584356
ko00561	Glycerolipid metabolism	2/989	63/7206	0.00927979207519
ko04540	Gap junction	8/989	128/7206	0.00941198207705
ko05134	Legionellosis	3/989	74/7206	0.0102754319052
ko04658	Th1 and Th2 cell differentiation	5/989	96/7206	0.0106825203428
ko04650	Natural killer cell mediated cytotoxicity	5/989	97/7206	0.0107686766649
ko05132	Salmonella infection	5/989	98/7206	0.0109865639831
ko05204	Chemical carcinogenesis	1/989	48/7206	0.0110671841018
ko04622	RIG-I-like receptor signaling pathway	2/989	62/7206	0.0140637999757
ko05030	Cocaine addiction	3/989	73/7206	0.0150793574055
ko04071	Sphingolipid signaling pathway	12/989	162/7206	0.015099765463
ko04115	p53 signaling pathway	18/989	74/7206	0.0156939832123
ko04070	Phosphatidylinositol signaling system	7/989	112/7206	0.0179563381406
ko04962	Vasopressin-regulated water reabsorption	2/989	58/7206	0.0196004995432
ko04914	Progesterone-mediated oocyte maturation	23/989	104/7206	0.0203165288496
ko04512	ECM-receptor interaction	4/989	79/7206	0.0205802811254
ko05120	Epithelial cell signaling in Helicobacter pylori infection	5/989	92/7206	0.0206939053783
ko05164	Influenza A	13/989	167/7206	0.0224171665774
ko00565	Ether lipid metabolism	1/989	42/7206	0.0242408558747
ko04530	Tight junction	20/989	228/7206	0.0244926316117
ko04130	SNARE interactions in vesicular transport	1/989	44/7206	0.0249475671101
ko04216	Ferroptosis	1/989	44/7206	0.0249475671101
ko04922	Glucagon signaling pathway	9/989	128/7206	0.0266159721746
ko04139	Mitophagy - yeast	10/989	37/7206	0.0281258565425
ko03060	Protein export	7/989	23/7206	0.0299832952378
ko05202	Transcriptional misregulation in cancer	36/989	188/7206	0.0318405375225
ko04910	Insulin signaling pathway	14/989	172/7206	0.0323632523451
ko00980	Metabolism of xenobiotics by cytochrome P450	1/989	40/7206	0.0359113202834
ko04978	Mineral absorption	1/989	40/7206	0.0359113202834
ko04145	Phagosome	13/989	162/7206	0.0366647132909
ko00330	Arginine and proline metabolism	3/989	61/7206	0.0401135228365
ko00590	Arachidonic acid metabolism	2/989	52/7206	0.0402811152957
ko00600	Sphingolipid metabolism	3/989	63/7206	0.0407448491454
ko04666	Fc gamma R-mediated phagocytosis	9/989	122/7206	0.0451687070539
ko00670	One carbon pool by folate	6/989	20/7206	0.0463768361133
ko04138	Autophagy - yeast	5/989	81/7206	0.049927854154