ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	174/1031	423/7206	1.13778311137e-44
ko04724	Glutamatergic synapse	82/1031	152/7206	3.75006906535e-31
ko05033	Nicotine addiction	44/1031	56/7206	3.09125091235e-27
ko05032	Morphine addiction	61/1031	110/7206	2.92741785586e-24
ko04713	Circadian entrainment	69/1031	136/7206	2.94851745586e-24
ko04727	GABAergic synapse	59/1031	110/7206	1.68904972173e-22
ko04728	Dopaminergic synapse	79/1031	185/7206	1.56734664893e-21
ko04721	Synaptic vesicle cycle	48/1031	80/7206	2.41611021618e-21
ko04725	Cholinergic synapse	71/1031	160/7206	1.32042821496e-20
ko04024	cAMP signaling pathway	95/1031	279/7206	2.12200112988e-17
ko04723	Retrograde endocannabinoid signaling	70/1031	175/7206	2.51101218959e-17
ko04742	Taste transduction	35/1031	61/7206	4.72809511297e-15
ko04726	Serotonergic synapse	56/1031	137/7206	1.4169890382e-14
ko04911	Insulin secretion	50/1031	117/7206	4.69521901039e-14
ko04921	Oxytocin signaling pathway	70/1031	209/7206	1.15199878653e-12
ko04020	Calcium signaling pathway	82/1031	265/7206	1.42576702341e-12
ko04744	Phototransduction	23/1031	36/7206	1.08395945392e-11
ko04261	Adrenergic signaling in cardiomyocytes	67/1031	205/7206	1.76629467705e-11
ko05031	Amphetamine addiction	39/1031	91/7206	2.71882066887e-11
ko04720	Long-term potentiation	39/1031	99/7206	5.69937384911e-10
ko04360	Axon guidance	69/1031	233/7206	8.47490332194e-10
ko03040	Spliceosome	1/1031	145/7206	5.70638185375e-09
ko04970	Salivary secretion	36/1031	95/7206	9.01071198087e-09
ko05030	Cocaine addiction	29/1031	73/7206	7.5229057557e-08
ko04740	Olfactory transduction	30/1031	80/7206	2.0510937485e-07
ko04060	Cytokine-cytokine receptor interaction	6/1031	191/7206	3.14114180417e-07
ko04925	Aldosterone synthesis and secretion	35/1031	105/7206	6.56613600735e-07
ko04010	MAPK signaling pathway	78/1031	321/7206	1.15003311045e-06
ko04971	Gastric acid secretion	33/1031	98/7206	1.17163915946e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1031	74/7206	1.5589566346e-06
ko05203	Viral carcinogenesis	15/1031	277/7206	2.70474689316e-06
ko05322	Systemic lupus erythematosus	4/1031	151/7206	2.71725592074e-06
ko05168	Herpes simplex infection	7/1031	182/7206	4.81448151091e-06
ko04924	Renin secretion	29/1031	86/7206	5.67084338181e-06
ko03013	RNA transport	6/1031	166/7206	8.5536611503e-06
ko05164	Influenza A	6/1031	167/7206	8.82280400426e-06
ko04022	cGMP-PKG signaling pathway	55/1031	216/7206	1.09562699811e-05
ko04120	Ubiquitin mediated proteolysis	4/1031	138/7206	1.1759823339e-05
ko04621	NOD-like receptor signaling pathway	6/1031	157/7206	2.48845471947e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1031	79/7206	2.56256337095e-05
ko04014	Ras signaling pathway	65/1031	279/7206	3.73556072081e-05
ko04730	Long-term depression	25/1031	78/7206	5.51598378976e-05
ko04141	Protein processing in endoplasmic reticulum	9/1031	184/7206	6.33724454559e-05
ko04966	Collecting duct acid secretion	12/1031	26/7206	9.56613584218e-05
ko04514	Cell adhesion molecules (CAMs)	35/1031	130/7206	0.000126187744688
ko04972	Pancreatic secretion	31/1031	111/7206	0.000167204735458
ko05414	Dilated cardiomyopathy	31/1031	112/7206	0.000187415988406
ko04260	Cardiac muscle contraction	28/1031	98/7206	0.000211433384008
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1031	14/7206	0.00022996174871
ko04540	Gap junction	34/1031	128/7206	0.000283823270472
ko04371	Apelin signaling pathway	43/1031	177/7206	0.000306571809483
ko04745	Phototransduction - fly	14/1031	38/7206	0.00046426753538
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1031	59/7206	0.000470853233773
ko05205	Proteoglycans in cancer	20/1031	271/7206	0.000518521900004
ko04750	Inflammatory mediator regulation of TRP channels	32/1031	122/7206	0.000564528738749
ko04072	Phospholipase D signaling pathway	46/1031	197/7206	0.000590724142394
ko04915	Estrogen signaling pathway	33/1031	131/7206	0.000906036630997
ko03008	Ribosome biogenesis in eukaryotes	2/1031	79/7206	0.000961564156916
ko04070	Phosphatidylinositol signaling system	29/1031	112/7206	0.000993066557924
ko05140	Leishmaniasis	2/1031	75/7206	0.00137932504483
ko00240	Pyrimidine metabolism	5/1031	110/7206	0.00144545197847
ko04612	Antigen processing and presentation	2/1031	77/7206	0.00146508332697
ko04064	NF-kappa B signaling pathway	4/1031	96/7206	0.00189937402642
ko05110	Vibrio cholerae infection	18/1031	63/7206	0.00308266431725
ko00480	Glutathione metabolism	1/1031	55/7206	0.0032660648719
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1031	182/7206	0.00360829364318
ko04110	Cell cycle	9/1031	145/7206	0.00369024972199
ko05169	Epstein-Barr virus infection	16/1031	206/7206	0.00460460311668
ko00590	Arachidonic acid metabolism	1/1031	52/7206	0.00487512157475
ko05162	Measles	7/1031	120/7206	0.00534720103865
ko04146	Peroxisome	4/1031	89/7206	0.00543556919377
ko04640	Hematopoietic cell lineage	2/1031	64/7206	0.00629556479672
ko03018	RNA degradation	4/1031	84/7206	0.00748296911603
ko05161	Hepatitis B	13/1031	173/7206	0.00801748216263
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1031	100/7206	0.00894768552041
ko04626	Plant-pathogen interaction	7/1031	18/7206	0.00905658446746
ko00330	Arginine and proline metabolism	2/1031	61/7206	0.00911617274271
ko04930	Type II diabetes mellitus	15/1031	54/7206	0.00951745872833
ko04976	Bile secretion	20/1031	80/7206	0.0096376384955
ko04214	Apoptosis - fly	3/1031	72/7206	0.0101500029329
ko00310	Lysine degradation	3/1031	73/7206	0.0104383442618
ko00620	Pyruvate metabolism	1/1031	46/7206	0.0108230959766
ko03420	Nucleotide excision repair	1/1031	46/7206	0.0108230959766
ko04923	Regulation of lipolysis in adipocytes	19/1031	77/7206	0.0134740168964
ko01200	Carbon metabolism	9/1031	128/7206	0.0150607757553
ko03022	Basal transcription factors	1/1031	44/7206	0.0160784736963
ko00071	Fatty acid degradation	1/1031	45/7206	0.0164696981427
ko00280	Valine, leucine and isoleucine degradation	2/1031	54/7206	0.0188997009108
ko04657	IL-17 signaling pathway	5/1031	87/7206	0.0197761824606
ko04391	Hippo signaling pathway - fly	21/1031	90/7206	0.0216598238926
ko04217	Necroptosis	15/1031	178/7206	0.0223522496957
ko00140	Steroid hormone biosynthesis	1/1031	41/7206	0.0238008163594
ko00983	Drug metabolism - other enzymes	1/1031	42/7206	0.0242991426552
ko04062	Chemokine signaling pathway	40/1031	201/7206	0.0246598474032
ko04964	Proximal tubule bicarbonate reclamation	9/1031	29/7206	0.0278089182989
ko04622	RIG-I-like receptor signaling pathway	3/1031	62/7206	0.0281859088024
ko00561	Glycerolipid metabolism	3/1031	63/7206	0.0284364507948
ko04015	Rap1 signaling pathway	53/1031	278/7206	0.0284706537558
ko04722	Neurotrophin signaling pathway	33/1031	160/7206	0.0291614559786
ko05034	Alcoholism	46/1031	238/7206	0.0299392413624
ko04144	Endocytosis	63/1031	342/7206	0.0322543085006
ko03410	Base excision repair	1/1031	38/7206	0.0351692669683
ko04912	GnRH signaling pathway	26/1031	122/7206	0.0356804637992
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1031	40/7206	0.0372292269485
ko05131	Shigellosis	5/1031	82/7206	0.0372411460424
ko05145	Toxoplasmosis	10/1031	126/7206	0.0393969205236
ko04916	Melanogenesis	29/1031	142/7206	0.0396898764892
ko00380	Tryptophan metabolism	2/1031	50/7206	0.039760020647
ko04973	Carbohydrate digestion and absorption	11/1031	42/7206	0.04249276209
ko04630	Jak-STAT signaling pathway	11/1031	132/7206	0.0450790156234
ko05133	Pertussis	6/1031	87/7206	0.0451242249528
ko04670	Leukocyte transendothelial migration	13/1031	151/7206	0.0451793674671