ko pathway ratio_in_study ratio_in_pop p_value ko04110 Cell cycle 61/441 145/7206 8.31933427506e-37 ko04111 Cell cycle - yeast 44/441 90/7206 3.98846201217e-30 ko03030 DNA replication 29/441 38/7206 2.63247171361e-28 ko03040 Spliceosome 48/441 145/7206 1.4645657939e-23 ko03460 Fanconi anemia pathway 27/441 51/7206 4.72802367169e-20 ko04113 Meiosis - yeast 31/441 70/7206 6.85635247572e-20 ko03440 Homologous recombination 23/441 41/7206 5.17345092641e-18 ko03430 Mismatch repair 16/441 22/7206 1.58216124249e-15 ko03420 Nucleotide excision repair 20/441 46/7206 4.53958645776e-13 ko03410 Base excision repair 18/441 38/7206 1.11145749207e-12 ko03013 RNA transport 34/441 166/7206 2.41921699054e-10 ko00240 Pyrimidine metabolism 27/441 110/7206 2.57997070211e-10 ko03008 Ribosome biogenesis in eukaryotes 21/441 79/7206 5.62615309928e-09 ko04144 Endocytosis 1/441 342/7206 1.02934542185e-08 ko05166 HTLV-I infection 42/441 292/7206 1.39468861015e-07 ko03015 mRNA surveillance pathway 20/441 93/7206 5.81387839714e-07 ko04114 Oocyte meiosis 25/441 139/7206 8.51508556256e-07 ko04914 Progesterone-mediated oocyte maturation 19/441 104/7206 1.41472079338e-05 ko04115 p53 signaling pathway 15/441 74/7206 3.20390075696e-05 ko05203 Viral carcinogenesis 35/441 277/7206 3.25168915404e-05 ko04218 Cellular senescence 26/441 177/7206 3.64947363969e-05 ko04024 cAMP signaling pathway 4/441 279/7206 0.000180667768887 ko05322 Systemic lupus erythematosus 22/441 151/7206 0.000181288545802 ko04022 cGMP-PKG signaling pathway 2/441 216/7206 0.000234052926728 ko04810 Regulation of actin cytoskeleton 4/441 264/7206 0.000361037731169 ko04014 Ras signaling pathway 5/441 279/7206 0.000794655016986 ko05152 Tuberculosis 2/441 187/7206 0.000997378152772 ko04270 Vascular smooth muscle contraction 1/441 154/7206 0.00102392486326 ko04621 NOD-like receptor signaling pathway 1/441 157/7206 0.00105254927977 ko00230 Purine metabolism 24/441 194/7206 0.00111136875668 ko04510 Focal adhesion 4/441 240/7206 0.00141453141606 ko04724 Glutamatergic synapse 1/441 152/7206 0.00158637850649 ko04120 Ubiquitin mediated proteolysis 18/441 138/7206 0.00193426088136 ko04723 Retrograde endocannabinoid signaling 2/441 175/7206 0.0020663948782 ko04713 Circadian entrainment 1/441 136/7206 0.00322848732461 ko05034 Alcoholism 26/441 238/7206 0.00352848763983 ko04072 Phospholipase D signaling pathway 3/441 197/7206 0.00359461452101 ko03022 Basal transcription factors 8/441 44/7206 0.00465099992418 ko05012 Parkinson's disease 2/441 155/7206 0.00601722462962 ko04666 Fc gamma R-mediated phagocytosis 1/441 122/7206 0.00681002500634 ko04066 HIF-1 signaling pathway 1/441 123/7206 0.00685623931426 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/441 182/7206 0.00692185841786 ko04015 Rap1 signaling pathway 7/441 278/7206 0.00704821078459 ko04530 Tight junction 5/441 228/7206 0.00735526650154 ko04360 Axon guidance 5/441 233/7206 0.00754528722303 ko04151 PI3K-Akt signaling pathway 12/441 390/7206 0.00866033942036 ko04142 Lysosome 2/441 151/7206 0.00878925393347 ko04668 TNF signaling pathway 1/441 120/7206 0.0105392228458 ko04727 GABAergic synapse 1/441 110/7206 0.0144707922819 ko05032 Morphine addiction 1/441 110/7206 0.0144707922819 ko04380 Osteoclast differentiation 2/441 134/7206 0.0170817913783 ko04010 MAPK signaling pathway 10/441 321/7206 0.0171018669187 ko04931 Insulin resistance 2/441 137/7206 0.0174542288554 ko03018 RNA degradation 11/441 84/7206 0.017698662967 ko04725 Cholinergic synapse 3/441 160/7206 0.018405044663 ko04520 Adherens junction 1/441 103/7206 0.0208843261141 ko04925 Aldosterone synthesis and secretion 1/441 105/7206 0.0213459552769 ko04659 Th17 cell differentiation 1/441 106/7206 0.0216988109621 ko05222 Small cell lung cancer 11/441 89/7206 0.0227926809893 ko05145 Toxoplasmosis 2/441 126/7206 0.0240620727803 ko04062 Chemokine signaling pathway 5/441 201/7206 0.0245611535659 ko04261 Adrenergic signaling in cardiomyocytes 5/441 205/7206 0.0250530877186 ko04630 Jak-STAT signaling pathway 2/441 132/7206 0.0251771285999 ko04371 Apelin signaling pathway 4/441 177/7206 0.0253515773995 ko05219 Bladder cancer 7/441 48/7206 0.0255511826556 ko05168 Herpes simplex infection 19/441 182/7206 0.0263350548653 ko00670 One carbon pool by folate 4/441 20/7206 0.0306613527589 ko04971 Gastric acid secretion 1/441 98/7206 0.030663149374 ko00564 Glycerophospholipid metabolism 1/441 99/7206 0.0311083487171 ko04750 Inflammatory mediator regulation of TRP channels 2/441 122/7206 0.0340670062175 ko05206 MicroRNAs in cancer 18/441 177/7206 0.0365815722198 ko04146 Peroxisome 1/441 89/7206 0.0433409868783 ko05031 Amphetamine addiction 1/441 91/7206 0.0440003003216 ko04611 Platelet activation 4/441 163/7206 0.0463392885149 ko04726 Serotonergic synapse 3/441 137/7206 0.047786838688