ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	126/783	423/7206	1.5581554015e-28
ko05033	Nicotine addiction	39/783	56/7206	1.72352429075e-25
ko04724	Glutamatergic synapse	64/783	152/7206	1.03999178053e-23
ko04728	Dopaminergic synapse	67/783	185/7206	2.00125483631e-20
ko04721	Synaptic vesicle cycle	42/783	80/7206	2.03719380481e-20
ko05032	Morphine addiction	47/783	110/7206	5.35568855957e-18
ko04713	Circadian entrainment	53/783	136/7206	5.36021060344e-18
ko04725	Cholinergic synapse	57/783	160/7206	3.85930206039e-17
ko04727	GABAergic synapse	45/783	110/7206	2.09917761951e-16
ko04723	Retrograde endocannabinoid signaling	57/783	175/7206	3.94925448243e-15
ko04024	cAMP signaling pathway	72/783	279/7206	8.43230223278e-13
ko04911	Insulin secretion	39/783	117/7206	4.42569130954e-11
ko05031	Amphetamine addiction	33/783	91/7206	1.11899639202e-10
ko04726	Serotonergic synapse	41/783	137/7206	6.13932011072e-10
ko04921	Oxytocin signaling pathway	53/783	209/7206	2.29660909133e-09
ko04261	Adrenergic signaling in cardiomyocytes	52/783	205/7206	3.36597542018e-09
ko04720	Long-term potentiation	32/783	99/7206	5.98449791717e-09
ko04020	Calcium signaling pathway	59/783	265/7206	4.93819586265e-08
ko05030	Cocaine addiction	24/783	73/7206	3.38061704296e-07
ko04970	Salivary secretion	28/783	95/7206	4.73574471569e-07
ko03040	Spliceosome	1/783	145/7206	2.13780473961e-06
ko04514	Cell adhesion molecules (CAMs)	33/783	130/7206	2.28857910177e-06
ko05203	Viral carcinogenesis	9/783	277/7206	4.26908275116e-06
ko04360	Axon guidance	49/783	233/7206	4.66741335081e-06
ko04730	Long-term depression	23/783	78/7206	4.94825881692e-06
ko04010	MAPK signaling pathway	62/783	321/7206	5.23485017857e-06
ko04966	Collecting duct acid secretion	12/783	26/7206	5.67480658229e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	22/783	74/7206	6.84461157805e-06
ko04744	Phototransduction	14/783	36/7206	1.09419640887e-05
ko04060	Cytokine-cytokine receptor interaction	5/783	191/7206	2.84161913396e-05
ko04742	Taste transduction	18/783	61/7206	5.2057202809e-05
ko04022	cGMP-PKG signaling pathway	43/783	216/7206	7.98456049031e-05
ko04745	Phototransduction - fly	13/783	38/7206	0.000108181056471
ko04925	Aldosterone synthesis and secretion	25/783	105/7206	0.000180727885324
ko05164	Influenza A	5/783	167/7206	0.000231035458084
ko04120	Ubiquitin mediated proteolysis	3/783	138/7206	0.00024611867509
ko05168	Herpes simplex infection	6/783	182/7206	0.000253632915026
ko04141	Protein processing in endoplasmic reticulum	6/783	184/7206	0.000259674319402
ko05322	Systemic lupus erythematosus	4/783	151/7206	0.000287896485851
ko03013	RNA transport	5/783	166/7206	0.000332712615439
ko04971	Gastric acid secretion	23/783	98/7206	0.000407376069812
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/783	79/7206	0.000725581407686
ko04260	Cardiac muscle contraction	22/783	98/7206	0.000814717738594
ko04740	Olfactory transduction	19/783	80/7206	0.00082577757771
ko05110	Vibrio cholerae infection	16/783	63/7206	0.000869446326873
ko04972	Pancreatic secretion	24/783	111/7206	0.00096221439456
ko04626	Plant-pathogen interaction	7/783	18/7206	0.00188617768418
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/783	92/7206	0.00202795394719
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/783	14/7206	0.00224845234752
ko04924	Renin secretion	19/783	86/7206	0.00238979196261
ko04621	NOD-like receptor signaling pathway	6/783	157/7206	0.00253540231422
ko04612	Antigen processing and presentation	1/783	77/7206	0.00263745564015
ko03008	Ribosome biogenesis in eukaryotes	1/783	79/7206	0.00281502835153
ko05169	Epstein-Barr virus infection	10/783	206/7206	0.00298063175741
ko04070	Phosphatidylinositol signaling system	23/783	112/7206	0.00306579572575
ko04072	Phospholipase D signaling pathway	35/783	197/7206	0.00339012746976
ko04540	Gap junction	25/783	128/7206	0.00361803949637
ko04915	Estrogen signaling pathway	25/783	131/7206	0.00428892006597
ko05162	Measles	4/783	120/7206	0.00446343265236
ko04014	Ras signaling pathway	45/783	279/7206	0.0058424977319
ko05166	HTLV-I infection	18/783	292/7206	0.00693655887968
ko04964	Proximal tubule bicarbonate reclamation	8/783	29/7206	0.0100672562289
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/783	59/7206	0.0105143434712
ko04064	NF-kappa B signaling pathway	3/783	96/7206	0.0118852078464
ko00240	Pyrimidine metabolism	4/783	110/7206	0.0122856618519
ko00330	Arginine and proline metabolism	1/783	61/7206	0.012303502091
ko05205	Proteoglycans in cancer	17/783	271/7206	0.0124324591341
ko05161	Hepatitis B	9/783	173/7206	0.0128613265131
ko04640	Hematopoietic cell lineage	1/783	64/7206	0.0131293947805
ko05034	Alcoholism	38/783	238/7206	0.0143674110165
ko04110	Cell cycle	7/783	145/7206	0.0147409117392
ko05140	Leishmaniasis	2/783	75/7206	0.014820467363
ko04146	Peroxisome	3/783	89/7206	0.0160284115022
ko04071	Sphingolipid signaling pathway	27/783	162/7206	0.0211421330505
ko00310	Lysine degradation	2/783	73/7206	0.0214318686094
ko05414	Dilated cardiomyopathy	20/783	112/7206	0.0214920243955
ko00280	Valine, leucine and isoleucine degradation	1/783	54/7206	0.0265065797854
ko04371	Apelin signaling pathway	29/783	177/7206	0.0266273694771
ko00480	Glutathione metabolism	1/783	55/7206	0.0268946549897
ko05010	Alzheimer's disease	32/783	202/7206	0.0284933176464
ko00512	Mucin type O-glycan biosynthesis	7/783	29/7206	0.032145239408
ko05323	Rheumatoid arthritis	16/783	89/7206	0.0384197174684
ko04015	Rap1 signaling pathway	41/783	278/7206	0.0387435479679
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/783	182/7206	0.0390664977536
ko00590	Arachidonic acid metabolism	1/783	52/7206	0.0400370964723
ko04930	Type II diabetes mellitus	11/783	54/7206	0.043265997412
ko01200	Carbon metabolism	7/783	128/7206	0.0448556033408