ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 29/507 134/7206 3.30610937638e-08 ko05321 Inflammatory bowel disease (IBD) 16/507 56/7206 8.49295040834e-07 ko04650 Natural killer cell mediated cytotoxicity 21/507 97/7206 2.65003016803e-06 ko05340 Primary immunodeficiency 11/507 30/7206 2.99882775656e-06 ko04621 NOD-like receptor signaling pathway 28/507 157/7206 3.69086777021e-06 ko04060 Cytokine-cytokine receptor interaction 31/507 191/7206 9.29593762459e-06 ko05140 Leishmaniasis 17/507 75/7206 1.24941218607e-05 ko05164 Influenza A 28/507 167/7206 1.69661450836e-05 ko00120 Primary bile acid biosynthesis 8/507 20/7206 3.35941871065e-05 ko04137 Mitophagy - animal 17/507 82/7206 4.29954893003e-05 ko04660 T cell receptor signaling pathway 22/507 124/7206 4.42215580137e-05 ko04620 Toll-like receptor signaling pathway 19/507 100/7206 5.55163066321e-05 ko05152 Tuberculosis 29/507 187/7206 5.56427686631e-05 ko05145 Toxoplasmosis 22/507 126/7206 5.69330122266e-05 ko05162 Measles 21/507 120/7206 8.08561051104e-05 ko04610 Complement and coagulation cascades 16/507 79/7206 9.66709521572e-05 ko04064 NF-kappa B signaling pathway 18/507 96/7206 0.000103856695324 ko04217 Necroptosis 26/507 178/7206 0.000300110279882 ko04658 Th1 and Th2 cell differentiation 17/507 96/7206 0.000329113754616 ko04146 Peroxisome 16/507 89/7206 0.000410587895921 ko05323 Rheumatoid arthritis 16/507 89/7206 0.000410587895921 ko03040 Spliceosome 1/507 145/7206 0.000456055695627 ko05150 Staphylococcus aureus infection 9/507 36/7206 0.000665198860704 ko04672 Intestinal immune network for IgA production 9/507 37/7206 0.000825225947493 ko05144 Malaria 10/507 45/7206 0.00092009896179 ko04210 Apoptosis 25/507 180/7206 0.000950438006788 ko05034 Alcoholism 5/507 238/7206 0.00108743636674 ko04662 B cell receptor signaling pathway 15/507 88/7206 0.00109761760519 ko05161 Hepatitis B 24/507 173/7206 0.00127630925143 ko05167 Kaposi's sarcoma-associated herpesvirus infection 26/507 191/7206 0.00130412958941 ko03010 Ribosome 1/507 129/7206 0.00144825960725 ko00592 alpha-Linolenic acid metabolism 6/507 19/7206 0.00144840514105 ko04659 Th17 cell differentiation 17/507 106/7206 0.0014827021855 ko00140 Steroid hormone biosynthesis 9/507 41/7206 0.00180620915672 ko04668 TNF signaling pathway 18/507 120/7206 0.00184811617016 ko05132 Salmonella infection 16/507 98/7206 0.00197040561913 ko04612 Antigen processing and presentation 13/507 77/7206 0.00252631827853 ko03320 PPAR signaling pathway 12/507 69/7206 0.00283210039821 ko04933 AGE-RAGE signaling pathway in diabetic complications 19/507 135/7206 0.00327206522715 ko05320 Autoimmune thyroid disease 7/507 29/7206 0.00327426071569 ko00071 Fatty acid degradation 9/507 45/7206 0.00355379432782 ko00982 Drug metabolism - cytochrome P450 8/507 37/7206 0.00355475436644 ko03013 RNA transport 3/507 166/7206 0.00494773800194 ko04068 FoxO signaling pathway 22/507 167/7206 0.00505156186662 ko05330 Allograft rejection 6/507 24/7206 0.00531657751693 ko04390 Hippo signaling pathway 4/507 188/7206 0.00533504754258 ko04630 Jak-STAT signaling pathway 18/507 132/7206 0.00557367187824 ko04666 Fc gamma R-mediated phagocytosis 17/507 122/7206 0.00625708822095 ko05332 Graft-versus-host disease 5/507 18/7206 0.00671691609365 ko00350 Tyrosine metabolism 7/507 33/7206 0.00701884715959 ko04145 Phagosome 21/507 162/7206 0.00721458634772 ko04611 Platelet activation 21/507 163/7206 0.00740822238703 ko00051 Fructose and mannose metabolism 8/507 42/7206 0.00797564262165 ko05133 Pertussis 13/507 87/7206 0.00908192911262 ko00590 Arachidonic acid metabolism 9/507 52/7206 0.00952683325835 ko04723 Retrograde endocannabinoid signaling 4/507 175/7206 0.00996483750791 ko04080 Neuroactive ligand-receptor interaction 17/507 423/7206 0.0105360377512 ko05168 Herpes simplex infection 22/507 182/7206 0.011690181194 ko05134 Legionellosis 11/507 74/7206 0.0181122346329 ko05020 Prion diseases 7/507 40/7206 0.0200343283643 ko03015 mRNA surveillance pathway 1/507 93/7206 0.0215762469993 ko04664 Fc epsilon RI signaling pathway 11/507 77/7206 0.0216726267635 ko00380 Tryptophan metabolism 8/507 50/7206 0.0221951336409 ko04623 Cytosolic DNA-sensing pathway 7/507 41/7206 0.0227451140011 ko05032 Morphine addiction 2/507 110/7206 0.0235411869802 ko04972 Pancreatic secretion 2/507 111/7206 0.0235882575445 ko05142 Chagas disease (American trypanosomiasis) 16/507 130/7206 0.0238950148065 ko00565 Ether lipid metabolism 7/507 42/7206 0.0256990082768 ko05146 Amoebiasis 13/507 99/7206 0.0267493918649 ko00360 Phenylalanine metabolism 4/507 17/7206 0.0276303558589 ko01040 Biosynthesis of unsaturated fatty acids 5/507 25/7206 0.0277428798924 ko00950 Isoquinoline alkaloid biosynthesis 3/507 10/7206 0.0286221160033 ko04710 Circadian rhythm 7/507 43/7206 0.0289046955137 ko04066 HIF-1 signaling pathway 15/507 123/7206 0.0316793070644 ko05160 Hepatitis C 18/507 153/7206 0.0354015235191 ko04622 RIG-I-like receptor signaling pathway 9/507 62/7206 0.0389080774465 ko00620 Pyruvate metabolism 7/507 46/7206 0.0401087349818 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/507 5/7206 0.0428410005439 ko00281 Geraniol degradation 2/507 5/7206 0.0428410005439 ko04110 Cell cycle 4/507 145/7206 0.0465574846925 ko05418 Fluid shear stress and atherosclerosis 19/507 173/7206 0.049003333941