ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 43/601 191/7206 8.9652828059e-10 ko04380 Osteoclast differentiation 31/601 134/7206 1.10251221945e-07 ko05340 Primary immunodeficiency 13/601 30/7206 2.63202303386e-07 ko04610 Complement and coagulation cascades 21/601 79/7206 1.14893536141e-06 ko05321 Inflammatory bowel disease (IBD) 16/601 56/7206 7.9378923671e-06 ko04658 Th1 and Th2 cell differentiation 22/601 96/7206 9.21096797817e-06 ko05034 Alcoholism 4/601 238/7206 2.05729227019e-05 ko04650 Natural killer cell mediated cytotoxicity 21/601 97/7206 3.67025358837e-05 ko04659 Th17 cell differentiation 22/601 106/7206 4.78934238231e-05 ko03040 Spliceosome 1/601 145/7206 9.44062911391e-05 ko03013 RNA transport 2/601 166/7206 9.70411625602e-05 ko04137 Mitophagy - animal 18/601 82/7206 0.000108259380064 ko05140 Leishmaniasis 17/601 75/7206 0.000109921664487 ko00120 Primary bile acid biosynthesis 8/601 20/7206 0.000113971995678 ko04710 Circadian rhythm 12/601 43/7206 0.000139559440825 ko04672 Intestinal immune network for IgA production 11/601 37/7206 0.00014177652669 ko05145 Toxoplasmosis 23/601 126/7206 0.000269443746225 ko03010 Ribosome 1/601 129/7206 0.000292431237193 ko05150 Staphylococcus aureus infection 10/601 36/7206 0.00052212580315 ko04621 NOD-like receptor signaling pathway 26/601 157/7206 0.000631229933893 ko04933 AGE-RAGE signaling pathway in diabetic complications 23/601 135/7206 0.000800874822494 ko04064 NF-kappa B signaling pathway 18/601 96/7206 0.00105960275899 ko04660 T cell receptor signaling pathway 21/601 124/7206 0.00151664429653 ko05162 Measles 20/601 120/7206 0.00234659191365 ko00590 Arachidonic acid metabolism 11/601 52/7206 0.00317274737221 ko00592 alpha-Linolenic acid metabolism 6/601 19/7206 0.00346599025975 ko05152 Tuberculosis 27/601 187/7206 0.00446763824954 ko00350 Tyrosine metabolism 8/601 33/7206 0.0047601335371 ko04391 Hippo signaling pathway - fly 1/601 90/7206 0.00632291891495 ko00950 Isoquinoline alkaloid biosynthesis 4/601 10/7206 0.0066912098795 ko00051 Fructose and mannose metabolism 9/601 42/7206 0.00673253866092 ko04110 Cell cycle 4/601 145/7206 0.00936061086895 ko04630 Jak-STAT signaling pathway 20/601 132/7206 0.00974427303403 ko05164 Influenza A 24/601 167/7206 0.00985063373652 ko04146 Peroxisome 15/601 89/7206 0.0101176040373 ko00360 Phenylalanine metabolism 5/601 17/7206 0.0105399590085 ko05144 Malaria 9/601 45/7206 0.0106990851894 ko05418 Fluid shear stress and atherosclerosis 24/601 173/7206 0.0117229960238 ko04723 Retrograde endocannabinoid signaling 6/601 175/7206 0.0124727547864 ko04721 Synaptic vesicle cycle 1/601 80/7206 0.0134432441595 ko04068 FoxO signaling pathway 23/601 167/7206 0.0152954614256 ko05224 Breast cancer 6/601 174/7206 0.0171398113488 ko04217 Necroptosis 24/601 178/7206 0.0185284807114 ko04640 Hematopoietic cell lineage 11/601 64/7206 0.0194279514368 ko05168 Herpes simplex infection 24/601 182/7206 0.0209065125497 ko04611 Platelet activation 22/601 163/7206 0.0213373609855 ko04620 Toll-like receptor signaling pathway 15/601 100/7206 0.0261577374357 ko05320 Autoimmune thyroid disease 6/601 29/7206 0.029765152817 ko04916 Melanogenesis 5/601 142/7206 0.0314445621167 ko04111 Cell cycle - yeast 2/601 90/7206 0.032538091394 ko04540 Gap junction 4/601 128/7206 0.0338039948911 ko04612 Antigen processing and presentation 12/601 77/7206 0.0342737111142 ko04727 GABAergic synapse 3/601 110/7206 0.0344321679018 ko05032 Morphine addiction 3/601 110/7206 0.0344321679018 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/601 4/7206 0.0371962689513 ko03320 PPAR signaling pathway 11/601 69/7206 0.0439950258469 ko05330 Allograft rejection 5/601 24/7206 0.0446699051794 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/601 191/7206 0.0449818349653 ko05203 Viral carcinogenesis 14/601 277/7206 0.0453408767461 ko05310 Asthma 4/601 17/7206 0.0475522388894 ko04662 B cell receptor signaling pathway 13/601 88/7206 0.0483416603787 ko05323 Rheumatoid arthritis 13/601 89/7206 0.0496632690491