ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1249	423/7206	1.44262691388e-46
ko04724	Glutamatergic synapse	87/1249	152/7206	3.68314473033e-29
ko05033	Nicotine addiction	45/1249	56/7206	5.9525855286e-25
ko05032	Morphine addiction	65/1249	110/7206	4.27884252446e-23
ko04713	Circadian entrainment	74/1249	136/7206	4.31302010579e-23
ko04727	GABAergic synapse	62/1249	110/7206	1.36351410403e-20
ko04725	Cholinergic synapse	77/1249	160/7206	1.08152338439e-19
ko04728	Dopaminergic synapse	84/1249	185/7206	2.37979984749e-19
ko04721	Synaptic vesicle cycle	48/1249	80/7206	9.54493331074e-18
ko04020	Calcium signaling pathway	101/1249	265/7206	2.08330541564e-16
ko04024	cAMP signaling pathway	104/1249	279/7206	5.98646430803e-16
ko04723	Retrograde endocannabinoid signaling	75/1249	175/7206	1.10643285065e-15
ko04911	Insulin secretion	57/1249	117/7206	3.51093374011e-15
ko04726	Serotonergic synapse	61/1249	137/7206	6.90509284612e-14
ko04921	Oxytocin signaling pathway	81/1249	209/7206	1.17078080151e-13
ko04742	Taste transduction	34/1249	61/7206	1.12141136321e-11
ko04261	Adrenergic signaling in cardiomyocytes	72/1249	205/7206	4.6423828848e-10
ko05031	Amphetamine addiction	41/1249	91/7206	5.92969445072e-10
ko03010	Ribosome	1/1249	129/7206	9.36169331972e-10
ko04970	Salivary secretion	41/1249	95/7206	2.90863490854e-09
ko04720	Long-term potentiation	42/1249	99/7206	3.50190772937e-09
ko04925	Aldosterone synthesis and secretion	42/1249	105/7206	2.99972669407e-08
ko03040	Spliceosome	4/1249	145/7206	5.05588649516e-08
ko04971	Gastric acid secretion	39/1249	98/7206	1.10840872127e-07
ko05168	Herpes simplex infection	8/1249	182/7206	1.47616262829e-07
ko05322	Systemic lupus erythematosus	5/1249	151/7206	1.64458961591e-07
ko04744	Phototransduction	20/1249	36/7206	2.26103819172e-07
ko03013	RNA transport	7/1249	166/7206	3.78721334745e-07
ko04740	Olfactory transduction	33/1249	80/7206	5.93340828972e-07
ko04022	cGMP-PKG signaling pathway	65/1249	216/7206	2.55919083064e-06
ko04360	Axon guidance	68/1249	233/7206	5.69300167985e-06
ko05203	Viral carcinogenesis	22/1249	277/7206	7.05594201142e-06
ko05030	Cocaine addiction	28/1249	73/7206	1.57729654075e-05
ko04745	Phototransduction - fly	18/1249	38/7206	1.78377840945e-05
ko04966	Collecting duct acid secretion	14/1249	26/7206	2.49309226937e-05
ko04730	Long-term depression	29/1249	78/7206	2.6945181098e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1249	74/7206	3.18720711343e-05
ko04110	Cell cycle	8/1249	145/7206	3.21843551417e-05
ko04070	Phosphatidylinositol signaling system	37/1249	112/7206	4.33107417781e-05
ko04072	Phospholipase D signaling pathway	57/1249	197/7206	5.03207541649e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1249	79/7206	7.02406354714e-05
ko04010	MAPK signaling pathway	83/1249	321/7206	8.13084640069e-05
ko04120	Ubiquitin mediated proteolysis	8/1249	138/7206	9.07058363296e-05
ko04014	Ras signaling pathway	74/1249	279/7206	9.62683717864e-05
ko04976	Bile secretion	28/1249	80/7206	0.000137849953756
ko04514	Cell adhesion molecules (CAMs)	40/1249	130/7206	0.000148582493484
ko05164	Influenza A	12/1249	167/7206	0.000173084340746
ko04060	Cytokine-cytokine receptor interaction	15/1249	191/7206	0.000204721725511
ko04972	Pancreatic secretion	35/1249	111/7206	0.000207978802582
ko04540	Gap junction	39/1249	128/7206	0.000219050999703
ko04270	Vascular smooth muscle contraction	45/1249	154/7206	0.000220009283366
ko04621	NOD-like receptor signaling pathway	11/1249	157/7206	0.000247249135344
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1249	79/7206	0.000254951201973
ko04371	Apelin signaling pathway	50/1249	177/7206	0.000260297965049
ko04750	Inflammatory mediator regulation of TRP channels	37/1249	122/7206	0.000389867032043
ko04141	Protein processing in endoplasmic reticulum	15/1249	184/7206	0.000495618287904
ko00520	Amino sugar and nucleotide sugar metabolism	1/1249	55/7206	0.000528836513923
ko05110	Vibrio cholerae infection	22/1249	63/7206	0.000655520000166
ko04710	Circadian rhythm	17/1249	43/7206	0.000736945089894
ko05140	Leishmaniasis	3/1249	75/7206	0.00101174372768
ko04260	Cardiac muscle contraction	30/1249	98/7206	0.00109932156569
ko04915	Estrogen signaling pathway	37/1249	131/7206	0.00157130755905
ko04964	Proximal tubule bicarbonate reclamation	12/1249	29/7206	0.00199152576266
ko05166	HTLV-I infection	32/1249	292/7206	0.00262222051663
ko03420	Nucleotide excision repair	1/1249	46/7206	0.0027879222877
ko05162	Measles	9/1249	120/7206	0.00318871263203
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1249	100/7206	0.00325493151094
ko05414	Dilated cardiomyopathy	32/1249	112/7206	0.00342996492995
ko04930	Type II diabetes mellitus	18/1249	54/7206	0.00359174852269
ko03022	Basal transcription factors	1/1249	44/7206	0.00424764501502
ko00071	Fatty acid degradation	1/1249	45/7206	0.0044793762753
ko04214	Apoptosis - fly	4/1249	72/7206	0.00461637784756
ko05131	Shigellosis	5/1249	82/7206	0.0047895487237
ko05169	Epstein-Barr virus infection	21/1249	206/7206	0.00491186371374
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1249	59/7206	0.00497484509243
ko04924	Renin secretion	25/1249	86/7206	0.00613570297429
ko04622	RIG-I-like receptor signaling pathway	3/1249	62/7206	0.00622891306353
ko04658	Th1 and Th2 cell differentiation	7/1249	96/7206	0.00630547409845
ko04657	IL-17 signaling pathway	6/1249	87/7206	0.00653167750486
ko05133	Pertussis	6/1249	87/7206	0.00653167750486
ko04626	Plant-pathogen interaction	8/1249	18/7206	0.00675584023927
ko05161	Hepatitis B	17/1249	173/7206	0.00784770165036
ko04217	Necroptosis	18/1249	178/7206	0.00883974146072
ko04922	Glucagon signaling pathway	34/1249	128/7206	0.00900188262073
ko04916	Melanogenesis	37/1249	142/7206	0.00950361163443
ko00630	Glyoxylate and dicarboxylate metabolism	1/1249	38/7206	0.00956186555322
ko03410	Base excision repair	1/1249	38/7206	0.00956186555322
ko04960	Aldosterone-regulated sodium reabsorption	14/1249	41/7206	0.0108103305405
ko04973	Carbohydrate digestion and absorption	14/1249	42/7206	0.0120639271137
ko05321	Inflammatory bowel disease (IBD)	3/1249	56/7206	0.0126509314912
ko00310	Lysine degradation	5/1249	73/7206	0.0128197102392
ko04213	Longevity regulating pathway - multiple species	24/1249	86/7206	0.0140014300516
ko04923	Regulation of lipolysis in adipocytes	22/1249	77/7206	0.0143617349262
ko04672	Intestinal immune network for IgA production	1/1249	37/7206	0.0145604367611
ko04146	Peroxisome	7/1249	89/7206	0.0158457626483
ko05144	Malaria	2/1249	45/7206	0.0169340752037
ko00280	Valine, leucine and isoleucine degradation	3/1249	54/7206	0.0180480412179
ko04064	NF-kappa B signaling pathway	8/1249	96/7206	0.0199672012084
ko00240	Pyrimidine metabolism	10/1249	110/7206	0.0215038051502
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1249	14/7206	0.0228001558271
ko04610	Complement and coagulation cascades	6/1249	79/7206	0.0235487226314
ko00590	Arachidonic acid metabolism	3/1249	52/7206	0.0257894112454
ko03018	RNA degradation	7/1249	84/7206	0.0286090630439
ko05205	Proteoglycans in cancer	34/1249	271/7206	0.0333316908728
ko00380	Tryptophan metabolism	3/1249	50/7206	0.0368669083689
ko04912	GnRH signaling pathway	30/1249	122/7206	0.0396443707396
ko04015	Rap1 signaling pathway	61/1249	278/7206	0.0431486117372
ko05016	Huntington's disease	26/1249	215/7206	0.043625815041
ko00562	Inositol phosphate metabolism	23/1249	89/7206	0.0469049749761
ko05416	Viral myocarditis	4/1249	55/7206	0.0485163733889
ko05231	Choline metabolism in cancer	32/1249	134/7206	0.0497357918694