ko pathway ratio_in_study ratio_in_pop p_value ko04110 Cell cycle 47/412 145/7206 6.24685188312e-24 ko03040 Spliceosome 42/412 145/7206 2.23256823567e-19 ko04111 Cell cycle - yeast 30/412 90/7206 5.23910527197e-16 ko03410 Base excision repair 18/412 38/7206 3.45350343014e-13 ko03030 DNA replication 18/412 38/7206 3.45350343014e-13 ko03460 Fanconi anemia pathway 19/412 51/7206 1.43984709854e-11 ko03440 Homologous recombination 17/412 41/7206 2.295488262e-11 ko04113 Meiosis - yeast 20/412 70/7206 1.00644489233e-09 ko05322 Systemic lupus erythematosus 30/412 151/7206 1.21695381889e-09 ko03008 Ribosome biogenesis in eukaryotes 21/412 79/7206 1.64793408379e-09 ko04144 Endocytosis 1/412 342/7206 5.6612239903e-08 ko00240 Pyrimidine metabolism 22/412 110/7206 1.8503615609e-07 ko03013 RNA transport 27/412 166/7206 6.38669938128e-07 ko03430 Mismatch repair 9/412 22/7206 1.52872761695e-06 ko05034 Alcoholism 32/412 238/7206 5.14673566124e-06 ko05202 Transcriptional misregulation in cancer 25/412 188/7206 7.47306875925e-05 ko05217 Basal cell carcinoma 13/412 68/7206 0.00010119749399 ko05166 HTLV-I infection 33/412 292/7206 0.000147487458448 ko04062 Chemokine signaling pathway 1/412 201/7206 0.000153169741066 ko03420 Nucleotide excision repair 10/412 46/7206 0.000212634971222 ko03015 mRNA surveillance pathway 15/412 93/7206 0.000225737809758 ko04114 Oocyte meiosis 19/412 139/7206 0.000326149413121 ko04060 Cytokine-cytokine receptor interaction 1/412 191/7206 0.000354118284826 ko04022 cGMP-PKG signaling pathway 2/412 216/7206 0.000491071701385 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/412 182/7206 0.000498197213226 ko04024 cAMP signaling pathway 4/412 279/7206 0.000519809940728 ko04330 Notch signaling pathway 11/412 62/7206 0.000672434726427 ko04921 Oxytocin signaling pathway 2/412 209/7206 0.000708408493913 ko04723 Retrograde endocannabinoid signaling 1/412 175/7206 0.000730038881823 ko04371 Apelin signaling pathway 1/412 177/7206 0.000759488222188 ko05203 Viral carcinogenesis 30/412 277/7206 0.000790754537505 ko04810 Regulation of actin cytoskeleton 4/412 264/7206 0.00102060760214 ko04218 Cellular senescence 21/412 177/7206 0.00141686957373 ko04621 NOD-like receptor signaling pathway 1/412 157/7206 0.00152127808559 ko04725 Cholinergic synapse 1/412 160/7206 0.00154230850418 ko05152 Tuberculosis 2/412 187/7206 0.00208948139734 ko04014 Ras signaling pathway 5/412 279/7206 0.00216923425368 ko04270 Vascular smooth muscle contraction 1/412 154/7206 0.00228084523599 ko04510 Focal adhesion 4/412 240/7206 0.00275212820556 ko04010 MAPK signaling pathway 7/412 321/7206 0.00292711729463 ko04115 p53 signaling pathway 11/412 74/7206 0.00298444048819 ko04713 Circadian entrainment 1/412 136/7206 0.00472771080221 ko04015 Rap1 signaling pathway 6/412 278/7206 0.00542274662688 ko04514 Cell adhesion molecules (CAMs) 1/412 130/7206 0.00688008333367 ko04915 Estrogen signaling pathway 1/412 131/7206 0.00690822383889 ko04722 Neurotrophin signaling pathway 2/412 160/7206 0.00872195508769 ko04550 Signaling pathways regulating pluripotency of stem cells 18/412 165/7206 0.00944200761813 ko04912 GnRH signaling pathway 1/412 122/7206 0.00998836667616 ko01200 Carbon metabolism 1/412 128/7206 0.0105645654847 ko04670 Leukocyte transendothelial migration 2/412 151/7206 0.0122167053185 ko04911 Insulin secretion 1/412 117/7206 0.0145486892235 ko04120 Ubiquitin mediated proteolysis 15/412 138/7206 0.0146240160032 ko04390 Hippo signaling pathway 19/412 188/7206 0.0154341897764 ko04914 Progesterone-mediated oocyte maturation 12/412 104/7206 0.0172355809062 ko04151 PI3K-Akt signaling pathway 12/412 390/7206 0.0181252933696 ko04012 ErbB signaling pathway 1/412 109/7206 0.0209688082427 ko04972 Pancreatic secretion 1/412 111/7206 0.0212166047422 ko04310 Wnt signaling pathway 18/412 181/7206 0.021403449608 ko05168 Herpes simplex infection 18/412 182/7206 0.0219294883404 ko04933 AGE-RAGE signaling pathway in diabetic complications 2/412 135/7206 0.0242681440887 ko04611 Platelet activation 3/412 163/7206 0.0255493967832 ko05224 Breast cancer 17/412 174/7206 0.0295654536908 ko04520 Adherens junction 1/412 103/7206 0.0304189216825 ko05206 MicroRNAs in cancer 17/412 177/7206 0.0318468351715 ko04540 Gap junction 2/412 128/7206 0.0340711918378 ko05142 Chagas disease (American trypanosomiasis) 2/412 130/7206 0.0342292679121 ko04630 Jak-STAT signaling pathway 2/412 132/7206 0.03472440078 ko04380 Osteoclast differentiation 2/412 134/7206 0.0355559991883 ko00230 Purine metabolism 18/412 194/7206 0.0398418945891 ko04530 Tight junction 6/412 228/7206 0.0411847999329 ko05211 Renal cell carcinoma 1/412 96/7206 0.0438511145088 ko04261 Adrenergic signaling in cardiomyocytes 5/412 205/7206 0.0450502856711 ko00564 Glycerophospholipid metabolism 1/412 99/7206 0.0452414453933 ko05146 Amoebiasis 1/412 99/7206 0.0452414453933 ko04620 Toll-like receptor signaling pathway 1/412 100/7206 0.0459685932805 ko04340 Hedgehog signaling pathway 7/412 58/7206 0.0460875903163 ko04668 TNF signaling pathway 2/412 120/7206 0.0477043829002 ko04750 Inflammatory mediator regulation of TRP channels 2/412 122/7206 0.0477561437315 ko04666 Fc gamma R-mediated phagocytosis 2/412 122/7206 0.0477561437315 ko04066 HIF-1 signaling pathway 2/412 123/7206 0.0479488242128 ko04660 T cell receptor signaling pathway 2/412 124/7206 0.048252106961 ko05145 Toxoplasmosis 2/412 126/7206 0.0491889673966 ko05160 Hepatitis C 3/412 153/7206 0.0496768933312