ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 42/591 191/7206 1.81735509929e-09 ko04610 Complement and coagulation cascades 21/591 79/7206 8.72062038686e-07 ko04070 Phosphatidylinositol signaling system 25/591 112/7206 2.79766335127e-06 ko04650 Natural killer cell mediated cytotoxicity 22/591 97/7206 8.40628039596e-06 ko04380 Osteoclast differentiation 27/591 134/7206 8.84730033569e-06 ko03040 Spliceosome 1/591 145/7206 9.04135865436e-05 ko00120 Primary bile acid biosynthesis 8/591 20/7206 0.000101161635118 ko05321 Inflammatory bowel disease (IBD) 14/591 56/7206 0.000121698249232 ko03013 RNA transport 2/591 166/7206 0.000144464702245 ko04630 Jak-STAT signaling pathway 24/591 132/7206 0.000165648062191 ko04621 NOD-like receptor signaling pathway 27/591 157/7206 0.00018133455082 ko03010 Ribosome 1/591 129/7206 0.000291141208936 ko05150 Staphylococcus aureus infection 10/591 36/7206 0.000456522037645 ko04710 Circadian rhythm 11/591 43/7206 0.000521197434876 ko04672 Intestinal immune network for IgA production 10/591 37/7206 0.00058044947898 ko04110 Cell cycle 2/591 145/7206 0.000632094917377 ko00590 Arachidonic acid metabolism 12/591 52/7206 0.000807097210169 ko04064 NF-kappa B signaling pathway 18/591 96/7206 0.000944045411331 ko05152 Tuberculosis 29/591 187/7206 0.000981304466573 ko04120 Ubiquitin mediated proteolysis 2/591 138/7206 0.00137575585864 ko04640 Hematopoietic cell lineage 13/591 64/7206 0.00175663825521 ko05224 Breast cancer 4/591 174/7206 0.00183436904311 ko04658 Th1 and Th2 cell differentiation 17/591 96/7206 0.00210801868045 ko04072 Phospholipase D signaling pathway 29/591 197/7206 0.0021255522648 ko05340 Primary immunodeficiency 8/591 30/7206 0.00225382145097 ko00592 alpha-Linolenic acid metabolism 6/591 19/7206 0.00318417369822 ko04659 Th17 cell differentiation 18/591 106/7206 0.0033841518392 ko04141 Protein processing in endoplasmic reticulum 5/591 184/7206 0.00379624332574 ko00140 Steroid hormone biosynthesis 9/591 41/7206 0.00510567943934 ko05323 Rheumatoid arthritis 15/591 89/7206 0.00591266799492 ko00051 Fructose and mannose metabolism 9/591 42/7206 0.0060379100182 ko04666 Fc gamma R-mediated phagocytosis 19/591 122/7206 0.00663434453965 ko04390 Hippo signaling pathway 6/591 188/7206 0.00690828840775 ko04020 Calcium signaling pathway 34/591 265/7206 0.00827448776975 ko00982 Drug metabolism - cytochrome P450 8/591 37/7206 0.0089340403759 ko05140 Leishmaniasis 13/591 75/7206 0.00894478859214 ko04550 Signaling pathways regulating pluripotency of stem cells 5/591 165/7206 0.00947983842497 ko05203 Viral carcinogenesis 12/591 277/7206 0.0137090600868 ko04670 Leukocyte transendothelial migration 21/591 151/7206 0.0154511136067 ko04662 B cell receptor signaling pathway 14/591 88/7206 0.0163714700015 ko00562 Inositol phosphate metabolism 14/591 89/7206 0.0172176535203 ko04270 Vascular smooth muscle contraction 21/591 154/7206 0.0173934247758 ko04660 T cell receptor signaling pathway 18/591 124/7206 0.0188792298118 ko05034 Alcoholism 10/591 238/7206 0.0215954004439 ko04744 Phototransduction 7/591 36/7206 0.0247830651441 ko05320 Autoimmune thyroid disease 6/591 29/7206 0.0276730607304 ko04111 Cell cycle - yeast 2/591 90/7206 0.0322755140269 ko04391 Hippo signaling pathway - fly 2/591 90/7206 0.0322755140269 ko05230 Central carbon metabolism in cancer 12/591 81/7206 0.0392853620392 ko04611 Platelet activation 21/591 163/7206 0.041249074946 ko05330 Allograft rejection 5/591 24/7206 0.0420000045479 ko05217 Basal cell carcinoma 1/591 68/7206 0.0420825288453 ko04022 cGMP-PKG signaling pathway 26/591 216/7206 0.0433626358571 ko05162 Measles 16/591 120/7206 0.0442702487904 ko05164 Influenza A 21/591 167/7206 0.0447863683428 ko05310 Asthma 4/591 17/7206 0.0451225180605 ko01522 Endocrine resistance 4/591 124/7206 0.0453012346018 ko04914 Progesterone-mediated oocyte maturation 3/591 104/7206 0.0460599421792 ko00350 Tyrosine metabolism 6/591 33/7206 0.0489566166068