ko pathway ratio_in_study ratio_in_pop p_value ko04723 Retrograde endocannabinoid signaling 66/633 175/7206 1.45640472253e-26 ko04080 Neuroactive ligand-receptor interaction 101/633 423/7206 3.77582921892e-22 ko05010 Alzheimer's disease 63/633 202/7206 2.69955102391e-20 ko00190 Oxidative phosphorylation 46/633 127/7206 5.84549907137e-18 ko05033 Nicotine addiction 30/633 56/7206 7.92011547785e-18 ko04724 Glutamatergic synapse 50/633 152/7206 2.19318469325e-17 ko05012 Parkinson's disease 46/633 155/7206 3.51386434807e-14 ko04713 Circadian entrainment 42/633 136/7206 1.0466535291e-13 ko04728 Dopaminergic synapse 48/633 185/7206 2.48547601904e-12 ko04727 GABAergic synapse 35/633 110/7206 4.80624829075e-12 ko04721 Synaptic vesicle cycle 28/633 80/7206 5.36604965311e-11 ko04911 Insulin secretion 34/633 117/7206 1.59899975265e-10 ko04921 Oxytocin signaling pathway 48/633 209/7206 2.63498366045e-10 ko05032 Morphine addiction 32/633 110/7206 5.42583665868e-10 ko04261 Adrenergic signaling in cardiomyocytes 46/633 205/7206 1.42045923089e-09 ko04725 Cholinergic synapse 38/633 160/7206 7.66959662337e-09 ko05031 Amphetamine addiction 27/633 91/7206 7.71758984725e-09 ko04260 Cardiac muscle contraction 28/633 98/7206 1.03213469636e-08 ko04024 cAMP signaling pathway 53/633 279/7206 5.56999452534e-08 ko04020 Calcium signaling pathway 49/633 265/7206 3.61399452632e-07 ko04970 Salivary secretion 25/633 95/7206 3.69623475199e-07 ko05016 Huntington's disease 42/633 215/7206 5.22576820303e-07 ko04726 Serotonergic synapse 31/633 137/7206 5.9702414504e-07 ko04060 Cytokine-cytokine receptor interaction 1/633 191/7206 7.47398966333e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 21/633 74/7206 8.2674253007e-07 ko04022 cGMP-PKG signaling pathway 41/633 216/7206 1.88126133739e-06 ko04932 Non-alcoholic fatty liver disease (NAFLD) 36/633 182/7206 3.18418179008e-06 ko04720 Long-term potentiation 23/633 99/7206 1.0740531984e-05 ko04010 MAPK signaling pathway 52/633 321/7206 1.10499233256e-05 ko05030 Cocaine addiction 19/633 73/7206 1.11191970393e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 19/633 79/7206 3.73204690066e-05 ko04742 Taste transduction 16/633 61/7206 4.93361666193e-05 ko00010 Glycolysis / Gluconeogenesis 18/633 74/7206 5.06830228262e-05 ko04745 Phototransduction - fly 12/633 38/7206 6.07055222486e-05 ko05168 Herpes simplex infection 3/633 182/7206 9.01460939611e-05 ko04971 Gastric acid secretion 21/633 98/7206 9.1978228609e-05 ko04120 Ubiquitin mediated proteolysis 1/633 138/7206 9.25267457206e-05 ko04730 Long-term depression 18/633 78/7206 0.000106126086546 ko04360 Axon guidance 38/633 233/7206 0.000144641451188 ko04925 Aldosterone synthesis and secretion 22/633 105/7206 0.000149483892996 ko05322 Systemic lupus erythematosus 2/633 151/7206 0.000204948339969 ko04514 Cell adhesion molecules (CAMs) 25/633 130/7206 0.000212141044091 ko05164 Influenza A 3/633 167/7206 0.000266133759125 ko03040 Spliceosome 2/633 145/7206 0.00029203296246 ko04924 Renin secretion 18/633 86/7206 0.000390824149467 ko05410 Hypertrophic cardiomyopathy (HCM) 20/633 100/7206 0.000452916320496 ko04964 Proximal tubule bicarbonate reclamation 9/633 29/7206 0.000590611512671 ko04922 Glucagon signaling pathway 23/633 128/7206 0.000767693649276 ko00710 Carbon fixation in photosynthetic organisms 8/633 27/7206 0.00166690842012 ko04550 Signaling pathways regulating pluripotency of stem cells 4/633 165/7206 0.00186781592113 ko04740 Olfactory transduction 16/633 80/7206 0.00196896167957 ko05414 Dilated cardiomyopathy 20/633 112/7206 0.00197033280513 ko04930 Type II diabetes mellitus 12/633 54/7206 0.00208456945578 ko01200 Carbon metabolism 22/633 128/7206 0.00223905711382 ko05203 Viral carcinogenesis 11/633 277/7206 0.00229483773788 ko04621 NOD-like receptor signaling pathway 4/633 157/7206 0.00248886415722 ko05166 HTLV-I infection 12/633 292/7206 0.00289021223762 ko04626 Plant-pathogen interaction 6/633 18/7206 0.00331921202993 ko04146 Peroxisome 1/633 89/7206 0.00422167488331 ko03013 RNA transport 5/633 166/7206 0.00503530521824 ko04966 Collecting duct acid secretion 7/633 26/7206 0.00583180366202 ko04350 TGF-beta signaling pathway 2/633 103/7206 0.00782732475118 ko00680 Methane metabolism 8/633 34/7206 0.00787913281418 ko04960 Aldosterone-regulated sodium reabsorption 9/633 41/7206 0.00797451361416 ko05162 Measles 3/633 120/7206 0.00876997699226 ko04973 Carbohydrate digestion and absorption 9/633 42/7206 0.00938099424832 ko00020 Citrate cycle (TCA cycle) 8/633 35/7206 0.00944843871592 ko04972 Pancreatic secretion 18/633 111/7206 0.0100651858718 ko05146 Amoebiasis 2/633 99/7206 0.0112185765324 ko04150 mTOR signaling pathway 7/633 184/7206 0.011774302518 ko05140 Leishmaniasis 1/633 75/7206 0.0132187626024 ko04610 Complement and coagulation cascades 1/633 79/7206 0.0140534154312 ko03008 Ribosome biogenesis in eukaryotes 1/633 79/7206 0.0140534154312 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/633 59/7206 0.0168213659162 ko00620 Pyruvate metabolism 9/633 46/7206 0.0169342178441 ko00240 Pyrimidine metabolism 3/633 110/7206 0.0170980267236 ko04110 Cell cycle 5/633 145/7206 0.0171627617012 ko04214 Apoptosis - fly 1/633 72/7206 0.0194344643139 ko05161 Hepatitis B 7/633 173/7206 0.0207274259539 ko04978 Mineral absorption 8/633 40/7206 0.0209522819484 ko05110 Vibrio cholerae infection 11/633 63/7206 0.0229972113226 ko04014 Ras signaling pathway 35/633 279/7206 0.0302729945954 ko04668 TNF signaling pathway 4/633 120/7206 0.0327956320166 ko04141 Protein processing in endoplasmic reticulum 8/633 184/7206 0.0334295515842 ko04914 Progesterone-mediated oocyte maturation 3/633 104/7206 0.0338048687246 ko04140 Autophagy - animal 7/633 164/7206 0.0358707569479 ko04913 Ovarian steroidogenesis 1/633 63/7206 0.0411968473566 ko00600 Sphingolipid metabolism 1/633 63/7206 0.0411968473566 ko04640 Hematopoietic cell lineage 1/633 64/7206 0.04189679695 ko04270 Vascular smooth muscle contraction 21/633 154/7206 0.0422520816584 ko05169 Epstein-Barr virus infection 10/633 206/7206 0.044757972307 ko00250 Alanine, aspartate and glutamate metabolism 7/633 38/7206 0.0448210095119 ko04064 NF-kappa B signaling pathway 3/633 96/7206 0.0452980884042 ko05200 Pathways in cancer 31/633 492/7206 0.0472033420228 ko04144 Endocytosis 20/633 342/7206 0.0499762314917