ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 52/514 152/7206 4.70322004949e-23 ko05032 Morphine addiction 39/514 110/7206 3.75914719488e-18 ko04744 Phototransduction 22/514 36/7206 5.6927146148e-17 ko04080 Neuroactive ligand-receptor interaction 78/514 423/7206 1.05576095575e-15 ko04727 GABAergic synapse 36/514 110/7206 1.44455912403e-15 ko05033 Nicotine addiction 25/514 56/7206 8.44032999712e-15 ko04723 Retrograde endocannabinoid signaling 44/514 175/7206 4.77218392982e-14 ko04713 Circadian entrainment 36/514 136/7206 2.03870883615e-12 ko04024 cAMP signaling pathway 51/514 279/7206 2.1086835006e-10 ko04911 Insulin secretion 30/514 117/7206 3.50468818012e-10 ko04728 Dopaminergic synapse 38/514 185/7206 1.66110560879e-09 ko04020 Calcium signaling pathway 47/514 265/7206 5.2526230114e-09 ko04921 Oxytocin signaling pathway 38/514 209/7206 5.56664317682e-08 ko04720 Long-term potentiation 24/514 99/7206 6.82607053908e-08 ko04072 Phospholipase D signaling pathway 36/514 197/7206 1.10402364751e-07 ko04742 Taste transduction 18/514 61/7206 1.24466098346e-07 ko04725 Cholinergic synapse 31/514 160/7206 2.2350485627e-07 ko04925 Aldosterone synthesis and secretion 24/514 105/7206 2.25498536582e-07 ko04721 Synaptic vesicle cycle 20/514 80/7206 5.02181804587e-07 ko04261 Adrenergic signaling in cardiomyocytes 36/514 205/7206 5.15568109023e-07 ko04726 Serotonergic synapse 26/514 137/7206 3.21785437778e-06 ko05203 Viral carcinogenesis 3/514 277/7206 3.66872928662e-06 ko04060 Cytokine-cytokine receptor interaction 1/514 191/7206 2.09142161417e-05 ko05168 Herpes simplex infection 1/514 182/7206 2.96433094421e-05 ko04740 Olfactory transduction 17/514 80/7206 3.66270678887e-05 ko05031 Amphetamine addiction 18/514 91/7206 5.97352491421e-05 ko04970 Salivary secretion 18/514 95/7206 0.000107507677881 ko04070 Phosphatidylinositol signaling system 20/514 112/7206 0.000107518426306 ko04010 MAPK signaling pathway 42/514 321/7206 0.00012983411266 ko05030 Cocaine addiction 15/514 73/7206 0.000156117603419 ko05414 Dilated cardiomyopathy 19/514 112/7206 0.000317300251541 ko04915 Estrogen signaling pathway 20/514 131/7206 0.000966947576148 ko04062 Chemokine signaling pathway 27/514 201/7206 0.00121500981846 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/514 79/7206 0.00123022124489 ko00515 Mannose type O-glycan biosynthesis 7/514 25/7206 0.00139735467538 ko00562 Inositol phosphate metabolism 15/514 89/7206 0.00141998778051 ko05205 Proteoglycans in cancer 7/514 271/7206 0.00156742702739 ko00230 Purine metabolism 26/514 194/7206 0.00160892789903 ko04022 cGMP-PKG signaling pathway 28/514 216/7206 0.00179714834145 ko05014 Amyotrophic lateral sclerosis (ALS) 13/514 74/7206 0.00197454114167 ko04670 Leukocyte transendothelial migration 2/514 151/7206 0.0020063044707 ko04971 Gastric acid secretion 16/514 98/7206 0.00208704198709 ko04110 Cell cycle 2/514 145/7206 0.00286696687615 ko04014 Ras signaling pathway 33/514 279/7206 0.0040283644709 ko04260 Cardiac muscle contraction 15/514 98/7206 0.0044299177923 ko04371 Apelin signaling pathway 23/514 177/7206 0.00448941541686 ko04972 Pancreatic secretion 16/514 111/7206 0.00760522520492 ko04730 Long-term depression 12/514 78/7206 0.0117339793725 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 6/514 28/7206 0.0124866120931 ko05202 Transcriptional misregulation in cancer 5/514 188/7206 0.013559263028 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/514 14/7206 0.0144019156511 ko05034 Alcoholism 27/514 238/7206 0.0144984676919 ko00512 Mucin type O-glycan biosynthesis 6/514 29/7206 0.0148213665748 ko04745 Phototransduction - fly 7/514 38/7206 0.0164057845517 ko04621 NOD-like receptor signaling pathway 4/514 157/7206 0.018196831005 ko04912 GnRH signaling pathway 16/514 122/7206 0.0187839789452 ko04923 Regulation of lipolysis in adipocytes 11/514 77/7206 0.0231486042336 ko04540 Gap junction 16/514 128/7206 0.0235988323685 ko04630 Jak-STAT signaling pathway 3/514 132/7206 0.0249623334773 ko00513 Various types of N-glycan biosynthesis 7/514 42/7206 0.0274580198269 ko05131 Shigellosis 1/514 82/7206 0.0293285931479 ko05410 Hypertrophic cardiomyopathy (HCM) 13/514 100/7206 0.029870589163 ko03018 RNA degradation 1/514 84/7206 0.0298962739626 ko03013 RNA transport 5/514 166/7206 0.0322646144995 ko05164 Influenza A 5/514 167/7206 0.0323124546673 ko04750 Inflammatory mediator regulation of TRP channels 15/514 122/7206 0.0325052283965 ko04514 Cell adhesion molecules (CAMs) 16/514 130/7206 0.036209834538 ko05169 Epstein-Barr virus infection 7/514 206/7206 0.0377642132331 ko05231 Choline metabolism in cancer 16/514 134/7206 0.0398113667606 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/514 182/7206 0.0402074431786 ko04150 mTOR signaling pathway 6/514 184/7206 0.0406021792945 ko04141 Protein processing in endoplasmic reticulum 6/514 184/7206 0.0406021792945 ko05110 Vibrio cholerae infection 9/514 63/7206 0.0427211199325 ko03008 Ribosome biogenesis in eukaryotes 1/514 79/7206 0.043661804011