ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 43/315 191/7206 8.36376153595e-20 ko04621 NOD-like receptor signaling pathway 35/315 157/7206 4.00349780208e-16 ko04380 Osteoclast differentiation 31/315 134/7206 7.17083390433e-15 ko05164 Influenza A 33/315 167/7206 1.19598876797e-13 ko05340 Primary immunodeficiency 15/315 30/7206 2.50815863625e-13 ko05168 Herpes simplex infection 34/315 182/7206 2.77035300712e-13 ko04217 Necroptosis 33/315 178/7206 7.95939968778e-13 ko05140 Leishmaniasis 21/315 75/7206 3.60644870428e-12 ko04620 Toll-like receptor signaling pathway 24/315 100/7206 3.89307752675e-12 ko05162 Measles 26/315 120/7206 6.0107473887e-12 ko05321 Inflammatory bowel disease (IBD) 18/315 56/7206 9.84510687906e-12 ko04064 NF-kappa B signaling pathway 23/315 96/7206 1.15646899209e-11 ko05145 Toxoplasmosis 26/315 126/7206 1.95584978917e-11 ko05152 Tuberculosis 31/315 187/7206 8.40302047164e-11 ko04650 Natural killer cell mediated cytotoxicity 22/315 97/7206 1.04886054409e-10 ko04612 Antigen processing and presentation 19/315 77/7206 4.37684829791e-10 ko04659 Th17 cell differentiation 22/315 106/7206 6.53129564882e-10 ko05320 Autoimmune thyroid disease 12/315 29/7206 1.05172076934e-09 ko05330 Allograft rejection 11/315 24/7206 1.40567262145e-09 ko05332 Graft-versus-host disease 9/315 18/7206 1.78696684775e-08 ko05150 Staphylococcus aureus infection 12/315 36/7206 1.92316272643e-08 ko04658 Th1 and Th2 cell differentiation 19/315 96/7206 2.2656563869e-08 ko04672 Intestinal immune network for IgA production 12/315 37/7206 2.73596209091e-08 ko04630 Jak-STAT signaling pathway 22/315 132/7206 4.70501270625e-08 ko04660 T cell receptor signaling pathway 21/315 124/7206 7.20596915435e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 26/315 191/7206 1.96358048248e-07 ko04622 RIG-I-like receptor signaling pathway 14/315 62/7206 3.02763217004e-07 ko04062 Chemokine signaling pathway 26/315 201/7206 5.44622748982e-07 ko04940 Type I diabetes mellitus 10/315 32/7206 6.04371143768e-07 ko04623 Cytosolic DNA-sensing pathway 11/315 41/7206 9.11318244962e-07 ko05161 Hepatitis B 23/315 173/7206 1.55493054481e-06 ko04145 Phagosome 22/315 162/7206 1.84001436794e-06 ko04210 Apoptosis 23/315 180/7206 3.11451738818e-06 ko05310 Asthma 7/315 17/7206 3.80174648674e-06 ko05323 Rheumatoid arthritis 15/315 89/7206 5.89319185095e-06 ko04668 TNF signaling pathway 17/315 120/7206 1.5901203024e-05 ko05133 Pertussis 14/315 87/7206 2.09018929028e-05 ko04662 B cell receptor signaling pathway 14/315 88/7206 2.38917280179e-05 ko05142 Chagas disease (American trypanosomiasis) 17/315 130/7206 4.58248984943e-05 ko04640 Hematopoietic cell lineage 11/315 64/7206 8.70932458217e-05 ko05160 Hepatitis C 18/315 153/7206 0.00011259473852 ko04610 Complement and coagulation cascades 12/315 79/7206 0.000144662506131 ko05416 Viral myocarditis 9/315 55/7206 0.00055871233528 ko05144 Malaria 8/315 45/7206 0.000638094182888 ko00120 Primary bile acid biosynthesis 5/315 20/7206 0.00139297729262 ko03050 Proteasome 8/315 54/7206 0.00218921996243 ko04666 Fc gamma R-mediated phagocytosis 13/315 122/7206 0.0024831282474 ko04080 Neuroactive ligand-receptor interaction 7/315 423/7206 0.00295847293533 ko05132 Salmonella infection 11/315 98/7206 0.00349902330336 ko05134 Legionellosis 9/315 74/7206 0.00469675489568 ko04310 Wnt signaling pathway 1/315 181/7206 0.00493144695514 ko04728 Dopaminergic synapse 1/315 185/7206 0.00513628930086 ko05166 HTLV-I infection 23/315 292/7206 0.00520648676337 ko04664 Fc epsilon RI signaling pathway 9/315 77/7206 0.0061162570491 ko04142 Lysosome 14/315 151/7206 0.00723220938511 ko05131 Shigellosis 9/315 82/7206 0.00919020946916 ko05169 Epstein-Barr virus infection 17/315 206/7206 0.0135830122003 ko04360 Axon guidance 3/315 233/7206 0.0136628652027 ko04020 Calcium signaling pathway 4/315 265/7206 0.013981428242 ko04514 Cell adhesion molecules (CAMs) 12/315 130/7206 0.0140080602111 ko05034 Alcoholism 3/315 238/7206 0.0140891884891 ko04724 Glutamatergic synapse 1/315 152/7206 0.0149399001822 ko04390 Hippo signaling pathway 2/315 188/7206 0.0176948559859 ko04530 Tight junction 3/315 228/7206 0.0194079779865 ko04916 Melanogenesis 1/315 142/7206 0.0215489890451 ko04670 Leukocyte transendothelial migration 13/315 151/7206 0.0234171333718 ko04611 Platelet activation 13/315 163/7206 0.031327657213 ko04713 Circadian entrainment 1/315 136/7206 0.0314466957005 ko04114 Oocyte meiosis 1/315 139/7206 0.0323465876492 ko00051 Fructose and mannose metabolism 5/315 42/7206 0.034979895948 ko04910 Insulin signaling pathway 2/315 172/7206 0.0353328550746 ko05224 Breast cancer 2/315 174/7206 0.0358767377384 ko00966 Glucosinolate biosynthesis 1/315 1/7206 0.0437135720234 ko04922 Glucagon signaling pathway 1/315 128/7206 0.0456283654767 ko01524 Platinum drug resistance 7/315 76/7206 0.0475142996229 ko04152 AMPK signaling pathway 2/315 161/7206 0.0489531569301