ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	205/1294	423/7206	4.20586132476e-50
ko04724	Glutamatergic synapse	90/1294	152/7206	1.76250080699e-30
ko05033	Nicotine addiction	48/1294	56/7206	2.46106471643e-28
ko05032	Morphine addiction	70/1294	110/7206	1.26913215999e-26
ko04713	Circadian entrainment	79/1294	136/7206	4.38375234456e-26
ko04727	GABAergic synapse	67/1294	110/7206	6.28597407231e-24
ko04721	Synaptic vesicle cycle	52/1294	80/7206	1.09850501493e-20
ko04728	Dopaminergic synapse	87/1294	185/7206	3.34297119888e-20
ko04725	Cholinergic synapse	78/1294	160/7206	2.12899942942e-19
ko04723	Retrograde endocannabinoid signaling	80/1294	175/7206	9.73487802282e-18
ko04020	Calcium signaling pathway	102/1294	265/7206	1.14199528639e-15
ko04024	cAMP signaling pathway	105/1294	279/7206	1.93735844088e-15
ko04726	Serotonergic synapse	64/1294	137/7206	5.51947563847e-15
ko04742	Taste transduction	36/1294	61/7206	7.76279562521e-13
ko04911	Insulin secretion	54/1294	117/7206	1.4165340903e-12
ko04744	Phototransduction	25/1294	36/7206	1.45455281907e-11
ko04921	Oxytocin signaling pathway	78/1294	209/7206	2.28835114463e-11
ko05031	Amphetamine addiction	43/1294	91/7206	1.08107052242e-10
ko03040	Spliceosome	2/1294	145/7206	2.22663268382e-10
ko03010	Ribosome	1/1294	129/7206	3.38704653681e-10
ko04970	Salivary secretion	42/1294	95/7206	2.31670943831e-09
ko04720	Long-term potentiation	43/1294	99/7206	2.91600896231e-09
ko04261	Adrenergic signaling in cardiomyocytes	70/1294	205/7206	1.65506461998e-08
ko05322	Systemic lupus erythematosus	5/1294	151/7206	4.44557503967e-08
ko04925	Aldosterone synthesis and secretion	41/1294	105/7206	2.70832984023e-07
ko04070	Phosphatidylinositol signaling system	43/1294	112/7206	2.90683956095e-07
ko03013	RNA transport	8/1294	166/7206	5.88519187688e-07
ko04966	Collecting duct acid secretion	16/1294	26/7206	9.27242733078e-07
ko04360	Axon guidance	72/1294	233/7206	9.29869851192e-07
ko05168	Herpes simplex infection	10/1294	182/7206	1.08782128166e-06
ko05030	Cocaine addiction	31/1294	73/7206	1.35609744216e-06
ko05203	Viral carcinogenesis	22/1294	277/7206	1.99134456808e-06
ko04740	Olfactory transduction	32/1294	80/7206	2.93467687165e-06
ko04971	Gastric acid secretion	37/1294	98/7206	3.34939286506e-06
ko04022	cGMP-PKG signaling pathway	66/1294	216/7206	5.19618804715e-06
ko04141	Protein processing in endoplasmic reticulum	12/1294	184/7206	9.14857733768e-06
ko04621	NOD-like receptor signaling pathway	9/1294	157/7206	1.18261421873e-05
ko04110	Cell cycle	8/1294	145/7206	1.50622860214e-05
ko04730	Long-term depression	30/1294	78/7206	1.77534775949e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1294	79/7206	4.44054072934e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1294	74/7206	4.63207912457e-05
ko04612	Antigen processing and presentation	2/1294	77/7206	6.74181055033e-05
ko04514	Cell adhesion molecules (CAMs)	42/1294	130/7206	6.82977163628e-05
ko05164	Influenza A	12/1294	167/7206	8.85926725914e-05
ko04745	Phototransduction - fly	17/1294	38/7206	0.00012005814077
ko04072	Phospholipase D signaling pathway	57/1294	197/7206	0.000143855588893
ko04010	MAPK signaling pathway	84/1294	321/7206	0.00018521150024
ko04710	Circadian rhythm	18/1294	43/7206	0.000215133192353
ko04972	Pancreatic secretion	36/1294	111/7206	0.00023718932194
ko04060	Cytokine-cytokine receptor interaction	16/1294	191/7206	0.000248669110444
ko04750	Inflammatory mediator regulation of TRP channels	38/1294	122/7206	0.000319956141417
ko04976	Bile secretion	28/1294	80/7206	0.000320767716014
ko04064	NF-kappa B signaling pathway	5/1294	96/7206	0.000405046149879
ko04540	Gap junction	39/1294	128/7206	0.000447609837835
ko00520	Amino sugar and nucleotide sugar metabolism	1/1294	55/7206	0.000543600375547
ko04014	Ras signaling pathway	73/1294	279/7206	0.000582306507671
ko05169	Epstein-Barr virus infection	19/1294	206/7206	0.000597100503376
ko05140	Leishmaniasis	3/1294	75/7206	0.000673133200294
ko04924	Renin secretion	28/1294	86/7206	0.000972714039606
ko04120	Ubiquitin mediated proteolysis	11/1294	138/7206	0.00108518825361
ko05110	Vibrio cholerae infection	22/1294	63/7206	0.0013391990804
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1294	79/7206	0.0016255397988
ko05161	Hepatitis B	16/1294	173/7206	0.00175674204334
ko03420	Nucleotide excision repair	1/1294	46/7206	0.00177928263025
ko04371	Apelin signaling pathway	48/1294	177/7206	0.00204672702284
ko04217	Necroptosis	17/1294	178/7206	0.00207642603905
ko05205	Proteoglycans in cancer	30/1294	271/7206	0.00208248053023
ko05145	Toxoplasmosis	10/1294	126/7206	0.00212007282193
ko04930	Type II diabetes mellitus	19/1294	54/7206	0.00213551257896
ko04923	Regulation of lipolysis in adipocytes	25/1294	77/7206	0.00238141536603
ko03022	Basal transcription factors	1/1294	44/7206	0.00268585996483
ko04964	Proximal tubule bicarbonate reclamation	12/1294	29/7206	0.00272193586614
ko05166	HTLV-I infection	34/1294	292/7206	0.00307059988707
ko04915	Estrogen signaling pathway	37/1294	131/7206	0.00376379192692
ko05162	Measles	10/1294	120/7206	0.00380465121316
ko04622	RIG-I-like receptor signaling pathway	3/1294	62/7206	0.00416586240005
ko05133	Pertussis	6/1294	87/7206	0.00458817874458
ko04610	Complement and coagulation cascades	5/1294	79/7206	0.00462528929236
ko00240	Pyrimidine metabolism	9/1294	110/7206	0.00550672977774
ko05414	Dilated cardiomyopathy	32/1294	112/7206	0.00586084159109
ko04922	Glucagon signaling pathway	35/1294	128/7206	0.00735200012344
ko04270	Vascular smooth muscle contraction	41/1294	154/7206	0.00758368586002
ko00562	Inositol phosphate metabolism	26/1294	89/7206	0.00798276617957
ko04510	Focal adhesion	28/1294	240/7206	0.0079913482045
ko04626	Plant-pathogen interaction	8/1294	18/7206	0.00841722953726
ko05131	Shigellosis	6/1294	82/7206	0.00874791594001
ko04672	Intestinal immune network for IgA production	1/1294	37/7206	0.00927016926907
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1294	59/7206	0.00933331481098
ko03410	Base excision repair	1/1294	38/7206	0.009415253369
ko04658	Th1 and Th2 cell differentiation	8/1294	96/7206	0.0106338749307
ko04260	Cardiac muscle contraction	28/1294	98/7206	0.0110223396164
ko00280	Valine, leucine and isoleucine degradation	3/1294	54/7206	0.0123390854632
ko05321	Inflammatory bowel disease (IBD)	3/1294	56/7206	0.0128826946439
ko04973	Carbohydrate digestion and absorption	14/1294	42/7206	0.0144702509501
ko04657	IL-17 signaling pathway	7/1294	87/7206	0.015850737142
ko05144	Malaria	2/1294	45/7206	0.0172495440016
ko00071	Fatty acid degradation	2/1294	45/7206	0.0172495440016
ko04711	Circadian rhythm - fly	6/1294	13/7206	0.018037885335
ko00860	Porphyrin and chlorophyll metabolism	1/1294	34/7206	0.0219749021215
ko05217	Basal cell carcinoma	5/1294	68/7206	0.0246109544268
ko04146	Peroxisome	8/1294	89/7206	0.0254904236494
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1294	14/7206	0.026863168275
ko05231	Choline metabolism in cancer	34/1294	134/7206	0.0302601034576
ko04214	Apoptosis - fly	6/1294	72/7206	0.0303075720403
ko00310	Lysine degradation	6/1294	73/7206	0.0305984852333
ko05340	Primary immunodeficiency	1/1294	30/7206	0.0314552820637
ko00480	Glutathione metabolism	4/1294	55/7206	0.0344922002948
ko05416	Viral myocarditis	4/1294	55/7206	0.0344922002948
ko05219	Bladder cancer	3/1294	48/7206	0.0359203703937
ko04960	Aldosterone-regulated sodium reabsorption	13/1294	41/7206	0.0378742897111
ko05200	Pathways in cancer	71/1294	492/7206	0.0383410719996
ko04113	Meiosis - yeast	6/1294	70/7206	0.0409653789778
ko00330	Arginine and proline metabolism	5/1294	61/7206	0.0444569110182
ko03018	RNA degradation	8/1294	84/7206	0.0445315165978
ko04152	AMPK signaling pathway	39/1294	161/7206	0.0476663530502
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1294	100/7206	0.0477114237091
ko04210	Apoptosis	22/1294	180/7206	0.0484992009532