ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 53/389 145/7206 3.6607754705e-31 ko03440 Homologous recombination 24/389 41/7206 1.22308782684e-20 ko03013 RNA transport 45/389 166/7206 1.91823374163e-20 ko03460 Fanconi anemia pathway 26/389 51/7206 3.46170344743e-20 ko04110 Cell cycle 41/389 145/7206 1.92856066438e-19 ko03030 DNA replication 22/389 38/7206 7.23919510584e-19 ko04111 Cell cycle - yeast 32/389 90/7206 1.05787120161e-18 ko04113 Meiosis - yeast 22/389 70/7206 5.61571509145e-12 ko03008 Ribosome biogenesis in eukaryotes 23/389 79/7206 1.09023786557e-11 ko00240 Pyrimidine metabolism 24/389 110/7206 2.68316604103e-09 ko03430 Mismatch repair 11/389 22/7206 4.06546324834e-09 ko03420 Nucleotide excision repair 15/389 46/7206 8.09776799978e-09 ko03410 Base excision repair 13/389 38/7206 4.26903168372e-08 ko03018 RNA degradation 18/389 84/7206 3.62189646483e-07 ko04144 Endocytosis 2/389 342/7206 1.73582942266e-06 ko03022 Basal transcription factors 11/389 44/7206 1.50141444967e-05 ko04810 Regulation of actin cytoskeleton 2/389 264/7206 7.68925887572e-05 ko04151 PI3K-Akt signaling pathway 6/389 390/7206 0.00011804590879 ko04114 Oocyte meiosis 19/389 139/7206 0.000155873499302 ko04024 cAMP signaling pathway 3/389 279/7206 0.000215390327804 ko05166 HTLV-I infection 31/389 292/7206 0.000277924803976 ko04072 Phospholipase D signaling pathway 1/389 197/7206 0.000333423253574 ko04510 Focal adhesion 2/389 240/7206 0.00036176299129 ko04914 Progesterone-mediated oocyte maturation 15/389 104/7206 0.000424255572146 ko03450 Non-homologous end-joining 5/389 15/7206 0.000854962071962 ko04015 Rap1 signaling pathway 4/389 278/7206 0.00102048269232 ko04014 Ras signaling pathway 4/389 279/7206 0.00102397091677 ko04022 cGMP-PKG signaling pathway 2/389 216/7206 0.00105336406445 ko04261 Adrenergic signaling in cardiomyocytes 2/389 205/7206 0.00146783942438 ko04921 Oxytocin signaling pathway 2/389 209/7206 0.00152291790006 ko04360 Axon guidance 3/389 233/7206 0.00177790642046 ko05010 Alzheimer's disease 2/389 202/7206 0.00219840446701 ko04152 AMPK signaling pathway 1/389 161/7206 0.00225766729725 ko04724 Glutamatergic synapse 1/389 152/7206 0.00327585201449 ko05012 Parkinson's disease 1/389 155/7206 0.00333211884102 ko04621 NOD-like receptor signaling pathway 1/389 157/7206 0.00342846666637 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/389 182/7206 0.00429027142871 ko04728 Dopaminergic synapse 2/389 185/7206 0.00436794930517 ko05152 Tuberculosis 2/389 187/7206 0.00448154793587 ko05205 Proteoglycans in cancer 5/389 271/7206 0.00556164078352 ko04723 Retrograde endocannabinoid signaling 2/389 175/7206 0.00611676340781 ko04371 Apelin signaling pathway 2/389 177/7206 0.00619026199596 ko04931 Insulin resistance 1/389 137/7206 0.00693764066025 ko04010 MAPK signaling pathway 7/389 321/7206 0.00733678744342 ko04218 Cellular senescence 18/389 177/7206 0.010026018666 ko04062 Chemokine signaling pathway 3/389 201/7206 0.0100712661599 ko04514 Cell adhesion molecules (CAMs) 1/389 130/7206 0.0100735387394 ko04630 Jak-STAT signaling pathway 1/389 132/7206 0.0101651191704 ko04530 Tight junction 4/389 228/7206 0.0103311182569 ko04713 Circadian entrainment 1/389 136/7206 0.0107438350532 ko04725 Cholinergic synapse 2/389 160/7206 0.0123100591803 ko04145 Phagosome 2/389 162/7206 0.012459200958 ko04611 Platelet activation 2/389 163/7206 0.0125809377329 ko04390 Hippo signaling pathway 3/389 188/7206 0.01343119054 ko04750 Inflammatory mediator regulation of TRP channels 1/389 122/7206 0.0145928783954 ko04666 Fc gamma R-mediated phagocytosis 1/389 122/7206 0.0145928783954 ko00310 Lysine degradation 9/389 73/7206 0.0160916866684 ko04142 Lysosome 2/389 151/7206 0.0173439655889 ko04115 p53 signaling pathway 9/389 74/7206 0.0174788429807 ko04141 Protein processing in endoplasmic reticulum 3/389 184/7206 0.0190105799981 ko05203 Viral carcinogenesis 24/389 277/7206 0.0202624064105 ko04668 TNF signaling pathway 1/389 120/7206 0.0220139818197 ko04910 Insulin signaling pathway 3/389 172/7206 0.0256702876352 ko04727 GABAergic synapse 1/389 110/7206 0.0308180223808 ko05032 Morphine addiction 1/389 110/7206 0.0308180223808 ko04972 Pancreatic secretion 1/389 111/7206 0.0311124407844 ko03015 mRNA surveillance pathway 10/389 93/7206 0.0332605528785 ko04726 Serotonergic synapse 2/389 137/7206 0.0343450270734 ko05169 Epstein-Barr virus infection 18/389 206/7206 0.0404212326571 ko04720 Long-term potentiation 1/389 99/7206 0.0438757196953 ko00564 Glycerophospholipid metabolism 1/389 99/7206 0.0438757196953 ko04520 Adherens junction 1/389 103/7206 0.0445560561871 ko05168 Herpes simplex infection 16/389 182/7206 0.0460422265368 ko04659 Th17 cell differentiation 1/389 106/7206 0.0463076352127 ko05142 Chagas disease (American trypanosomiasis) 2/389 130/7206 0.0481491487519