ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	215/1320	423/7206	1.24310654425e-55
ko04724	Glutamatergic synapse	92/1320	152/7206	1.71284987704e-31
ko05033	Nicotine addiction	50/1320	56/7206	6.65420413294e-31
ko05032	Morphine addiction	71/1320	110/7206	5.34505781916e-27
ko04713	Circadian entrainment	79/1320	136/7206	1.72944846667e-25
ko04727	GABAergic synapse	68/1320	110/7206	2.76101080077e-24
ko04721	Synaptic vesicle cycle	54/1320	80/7206	3.41086836121e-22
ko04728	Dopaminergic synapse	88/1320	185/7206	3.07635622906e-20
ko04725	Cholinergic synapse	79/1320	160/7206	1.62620635451e-19
ko04020	Calcium signaling pathway	109/1320	265/7206	1.05095991166e-18
ko04024	cAMP signaling pathway	110/1320	279/7206	3.89459509424e-17
ko04723	Retrograde endocannabinoid signaling	79/1320	175/7206	1.30266100044e-16
ko04742	Taste transduction	40/1320	61/7206	4.38737226222e-16
ko04911	Insulin secretion	58/1320	117/7206	9.67246356094e-15
ko04744	Phototransduction	27/1320	36/7206	1.70326797891e-13
ko04726	Serotonergic synapse	62/1320	137/7206	2.34880576604e-13
ko04921	Oxytocin signaling pathway	82/1320	209/7206	5.84831831643e-13
ko03040	Spliceosome	1/1320	145/7206	9.60257656232e-12
ko04261	Adrenergic signaling in cardiomyocytes	78/1320	205/7206	2.09940278413e-11
ko04740	Olfactory transduction	41/1320	80/7206	2.15139027431e-11
ko04720	Long-term potentiation	47/1320	99/7206	2.4420578346e-11
ko05031	Amphetamine addiction	44/1320	91/7206	4.94770562822e-11
ko04970	Salivary secretion	45/1320	95/7206	7.16698459114e-11
ko04360	Axon guidance	83/1320	233/7206	2.27414951694e-10
ko05203	Viral carcinogenesis	18/1320	277/7206	1.18602264846e-08
ko03013	RNA transport	7/1320	166/7206	7.16193957601e-08
ko04022	cGMP-PKG signaling pathway	72/1320	216/7206	8.40780288771e-08
ko05168	Herpes simplex infection	9/1320	182/7206	1.54939673302e-07
ko05030	Cocaine addiction	32/1320	73/7206	3.84252073854e-07
ko04971	Gastric acid secretion	39/1320	98/7206	5.1874490539e-07
ko04060	Cytokine-cytokine receptor interaction	11/1320	191/7206	5.44406975009e-07
ko04925	Aldosterone synthesis and secretion	41/1320	105/7206	5.93081463945e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1320	74/7206	2.21760855346e-06
ko04540	Gap junction	46/1320	128/7206	2.32503361562e-06
ko05322	Systemic lupus erythematosus	8/1320	151/7206	3.46219358786e-06
ko05164	Influenza A	10/1320	167/7206	6.03085731676e-06
ko04966	Collecting duct acid secretion	15/1320	26/7206	8.23145398721e-06
ko04924	Renin secretion	33/1320	86/7206	1.4182135849e-05
ko04141	Protein processing in endoplasmic reticulum	13/1320	184/7206	1.7042494441e-05
ko04010	MAPK signaling pathway	89/1320	321/7206	2.29380307704e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1320	79/7206	2.82892799737e-05
ko04745	Phototransduction - fly	18/1320	38/7206	3.89221326073e-05
ko04972	Pancreatic secretion	38/1320	111/7206	5.5733421412e-05
ko05110	Vibrio cholerae infection	25/1320	63/7206	5.92009774281e-05
ko04621	NOD-like receptor signaling pathway	11/1320	157/7206	6.23543850784e-05
ko04070	Phosphatidylinositol signaling system	38/1320	112/7206	6.40151072835e-05
ko04730	Long-term depression	29/1320	78/7206	8.36585467414e-05
ko04146	Peroxisome	4/1320	89/7206	0.000164124079425
ko04014	Ras signaling pathway	76/1320	279/7206	0.000189794372603
ko04610	Complement and coagulation cascades	3/1320	79/7206	0.000195011301341
ko04514	Cell adhesion molecules (CAMs)	41/1320	130/7206	0.000219733987463
ko04064	NF-kappa B signaling pathway	5/1320	96/7206	0.00027202359055
ko05205	Proteoglycans in cancer	28/1320	271/7206	0.000296513312947
ko04110	Cell cycle	11/1320	145/7206	0.000308772439368
ko05162	Measles	8/1320	120/7206	0.000319843546181
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1320	79/7206	0.000327655934093
ko05169	Epstein-Barr virus infection	19/1320	206/7206	0.00033218184145
ko04976	Bile secretion	28/1320	80/7206	0.000368384330483
ko05140	Leishmaniasis	3/1320	75/7206	0.000428206770216
ko00240	Pyrimidine metabolism	7/1320	110/7206	0.000437639423297
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1320	59/7206	0.000531677027969
ko04260	Cardiac muscle contraction	32/1320	98/7206	0.000547053179114
ko04072	Phospholipase D signaling pathway	55/1320	197/7206	0.00073498195618
ko04120	Ubiquitin mediated proteolysis	11/1320	138/7206	0.000782439828515
ko05414	Dilated cardiomyopathy	35/1320	112/7206	0.000794672565707
ko04964	Proximal tubule bicarbonate reclamation	13/1320	29/7206	0.000901441655261
ko04371	Apelin signaling pathway	50/1320	177/7206	0.0010747836172
ko04750	Inflammatory mediator regulation of TRP channels	37/1320	122/7206	0.00126695677424
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1320	14/7206	0.0013045682104
ko04612	Antigen processing and presentation	4/1320	77/7206	0.0015502590358
ko05321	Inflammatory bowel disease (IBD)	2/1320	56/7206	0.00160091797101
ko03420	Nucleotide excision repair	1/1320	46/7206	0.00174277755817
ko00310	Lysine degradation	4/1320	73/7206	0.00215148396124
ko04626	Plant-pathogen interaction	9/1320	18/7206	0.00223497305233
ko00480	Glutathione metabolism	2/1320	55/7206	0.00240140810948
ko04923	Regulation of lipolysis in adipocytes	25/1320	77/7206	0.00266376970856
ko03022	Basal transcription factors	1/1320	44/7206	0.00266672964253
ko05144	Malaria	1/1320	45/7206	0.00283734410143
ko00071	Fatty acid degradation	1/1320	45/7206	0.00283734410143
ko04214	Apoptosis - fly	4/1320	72/7206	0.00313534712941
ko04657	IL-17 signaling pathway	6/1320	87/7206	0.00324019502211
ko05133	Pertussis	6/1320	87/7206	0.00324019502211
ko00590	Arachidonic acid metabolism	2/1320	52/7206	0.00349907152541
ko04622	RIG-I-like receptor signaling pathway	3/1320	62/7206	0.00428771083102
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1320	182/7206	0.00465205393384
ko05161	Hepatitis B	18/1320	173/7206	0.00515790165229
ko04915	Estrogen signaling pathway	37/1320	131/7206	0.00581860394702
ko04115	p53 signaling pathway	5/1320	74/7206	0.00633535770882
ko03018	RNA degradation	6/1320	84/7206	0.00637877758766
ko05145	Toxoplasmosis	12/1320	126/7206	0.00745075314157
ko04658	Th1 and Th2 cell differentiation	8/1320	96/7206	0.00777334389133
ko04640	Hematopoietic cell lineage	4/1320	64/7206	0.008827908301
ko05131	Shigellosis	6/1320	82/7206	0.00891884373138
ko00630	Glyoxylate and dicarboxylate metabolism	1/1320	38/7206	0.00964698099539
ko05166	HTLV-I infection	37/1320	292/7206	0.0106067736092
ko00330	Arginine and proline metabolism	4/1320	61/7206	0.0124744235518
ko04620	Toll-like receptor signaling pathway	9/1320	100/7206	0.0129634193615
ko01524	Platinum drug resistance	6/1320	76/7206	0.0162650904813
ko04912	GnRH signaling pathway	33/1320	122/7206	0.0175163414743
ko05418	Fluid shear stress and atherosclerosis	20/1320	173/7206	0.0215718645354
ko04630	Jak-STAT signaling pathway	14/1320	132/7206	0.0223855456821
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1320	40/7206	0.023797837566
ko00260	Glycine, serine and threonine metabolism	3/1320	48/7206	0.0248164171588
ko04918	Thyroid hormone synthesis	24/1320	86/7206	0.0248553307527
ko04142	Lysosome	17/1320	151/7206	0.0249248661182
ko04710	Circadian rhythm	14/1320	43/7206	0.0268547553482
ko00280	Valine, leucine and isoleucine degradation	4/1320	54/7206	0.0340959407304
ko03410	Base excision repair	2/1320	38/7206	0.0345576632074
ko05132	Salmonella infection	10/1320	98/7206	0.0351793111489
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1320	100/7206	0.0360235000516
ko04922	Glucagon signaling pathway	33/1320	128/7206	0.0370338717825
ko00562	Inositol phosphate metabolism	24/1320	89/7206	0.0386278988018
ko03320	PPAR signaling pathway	6/1320	69/7206	0.0407235330988
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1320	26/7206	0.0409636126555
ko01212	Fatty acid metabolism	5/1320	60/7206	0.043998770978
ko05202	Transcriptional misregulation in cancer	24/1320	188/7206	0.0449855182509
ko05215	Prostate cancer	12/1320	111/7206	0.0466987532893
ko04015	Rap1 signaling pathway	64/1320	278/7206	0.0476153164782
ko05320	Autoimmune thyroid disease	1/1320	29/7206	0.0493781145413
ko04930	Type II diabetes mellitus	16/1320	54/7206	0.049437922941