ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	206/1280	423/7206	1.2421038162e-51
ko04724	Glutamatergic synapse	94/1280	152/7206	2.2385222482e-34
ko05033	Nicotine addiction	50/1280	56/7206	1.44279066169e-31
ko05032	Morphine addiction	71/1280	110/7206	7.33702194365e-28
ko04713	Circadian entrainment	80/1280	136/7206	2.99282442741e-27
ko04727	GABAergic synapse	69/1280	110/7206	5.31290179631e-26
ko04721	Synaptic vesicle cycle	55/1280	80/7206	7.2510695356e-24
ko04725	Cholinergic synapse	79/1280	160/7206	2.27893198941e-20
ko04728	Dopaminergic synapse	86/1280	185/7206	6.81924990535e-20
ko04024	cAMP signaling pathway	111/1280	279/7206	1.23185023165e-18
ko04723	Retrograde endocannabinoid signaling	80/1280	175/7206	4.95152482472e-18
ko04020	Calcium signaling pathway	105/1280	265/7206	1.66894550631e-17
ko04911	Insulin secretion	59/1280	117/7206	4.75998374698e-16
ko04742	Taste transduction	39/1280	61/7206	1.25970018347e-15
ko04921	Oxytocin signaling pathway	85/1280	209/7206	3.69360521736e-15
ko04744	Phototransduction	28/1280	36/7206	5.25422921578e-15
ko04726	Serotonergic synapse	62/1280	137/7206	5.47763266639e-14
ko04720	Long-term potentiation	49/1280	99/7206	3.8272857109e-13
ko04740	Olfactory transduction	42/1280	80/7206	1.48975277045e-12
ko04970	Salivary secretion	46/1280	95/7206	5.49308468825e-12
ko05031	Amphetamine addiction	44/1280	91/7206	1.70030954852e-11
ko04261	Adrenergic signaling in cardiomyocytes	76/1280	205/7206	2.49610200605e-11
ko03040	Spliceosome	1/1280	145/7206	2.73337614809e-11
ko05203	Viral carcinogenesis	16/1280	277/7206	4.4501443336e-09
ko04971	Gastric acid secretion	42/1280	98/7206	5.18172367727e-09
ko05168	Herpes simplex infection	7/1280	182/7206	1.78164791921e-08
ko04925	Aldosterone synthesis and secretion	43/1280	105/7206	1.8822759964e-08
ko04360	Axon guidance	75/1280	233/7206	6.52159118612e-08
ko04060	Cytokine-cytokine receptor interaction	9/1280	191/7206	7.74507006096e-08
ko04022	cGMP-PKG signaling pathway	70/1280	216/7206	1.082411567e-07
ko04540	Gap junction	48/1280	128/7206	1.17339125336e-07
ko03013	RNA transport	7/1280	166/7206	1.66587217292e-07
ko05030	Cocaine addiction	31/1280	73/7206	6.77031886808e-07
ko04966	Collecting duct acid secretion	16/1280	26/7206	7.95494207671e-07
ko04924	Renin secretion	34/1280	86/7206	2.34944396462e-06
ko05164	Influenza A	9/1280	167/7206	2.86666655294e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1280	74/7206	3.76432540668e-06
ko04972	Pancreatic secretion	40/1280	111/7206	3.77072205752e-06
ko05322	Systemic lupus erythematosus	8/1280	151/7206	7.55537999531e-06
ko04621	NOD-like receptor signaling pathway	9/1280	157/7206	1.16058339916e-05
ko04141	Protein processing in endoplasmic reticulum	12/1280	184/7206	1.31663866425e-05
ko04120	Ubiquitin mediated proteolysis	7/1280	138/7206	1.39804575615e-05
ko05110	Vibrio cholerae infection	26/1280	63/7206	1.42390132318e-05
ko04260	Cardiac muscle contraction	35/1280	98/7206	2.28228002903e-05
ko04976	Bile secretion	30/1280	80/7206	2.3410803114e-05
ko04745	Phototransduction - fly	18/1280	38/7206	2.52577056105e-05
ko04010	MAPK signaling pathway	86/1280	321/7206	3.63951775302e-05
ko04730	Long-term depression	29/1280	78/7206	3.80903566691e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1280	59/7206	3.84670655796e-05
ko05169	Epstein-Barr virus infection	16/1280	206/7206	4.18652351139e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1280	79/7206	4.50117440005e-05
ko05162	Measles	6/1280	120/7206	5.28985186562e-05
ko04514	Cell adhesion molecules (CAMs)	42/1280	130/7206	6.19575037186e-05
ko04070	Phosphatidylinositol signaling system	37/1280	112/7206	8.44582505622e-05
ko05140	Leishmaniasis	2/1280	75/7206	0.000101476821005
ko04750	Inflammatory mediator regulation of TRP channels	39/1280	122/7206	0.000111026744992
ko04064	NF-kappa B signaling pathway	4/1280	96/7206	0.000121536673697
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1280	79/7206	0.000153010075901
ko05205	Proteoglycans in cancer	26/1280	271/7206	0.000177568840998
ko05414	Dilated cardiomyopathy	36/1280	112/7206	0.00023750532346
ko04110	Cell cycle	10/1280	145/7206	0.000245669820243
ko04371	Apelin signaling pathway	51/1280	177/7206	0.00029360745605
ko04915	Estrogen signaling pathway	40/1280	131/7206	0.000300675257404
ko04626	Plant-pathogen interaction	10/1280	18/7206	0.000330854435951
ko04146	Peroxisome	4/1280	89/7206	0.00037431718754
ko00520	Amino sugar and nucleotide sugar metabolism	1/1280	55/7206	0.000528704039725
ko00480	Glutathione metabolism	1/1280	55/7206	0.000528704039725
ko04014	Ras signaling pathway	72/1280	279/7206	0.000569681477109
ko04072	Phospholipase D signaling pathway	54/1280	197/7206	0.000625027562427
ko04964	Proximal tubule bicarbonate reclamation	13/1280	29/7206	0.000664576691357
ko04214	Apoptosis - fly	3/1280	72/7206	0.000942951153789
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1280	14/7206	0.00105525557427
ko04923	Regulation of lipolysis in adipocytes	25/1280	77/7206	0.00148406630175
ko04610	Complement and coagulation cascades	4/1280	79/7206	0.00158124158436
ko04612	Antigen processing and presentation	4/1280	77/7206	0.0022986148688
ko00240	Pyrimidine metabolism	8/1280	110/7206	0.00232932035603
ko05161	Hepatitis B	16/1280	173/7206	0.00234914358893
ko05321	Inflammatory bowel disease (IBD)	2/1280	56/7206	0.00244314324368
ko05144	Malaria	1/1280	45/7206	0.00272590788543
ko00071	Fatty acid degradation	1/1280	45/7206	0.00272590788543
ko03420	Nucleotide excision repair	1/1280	46/7206	0.00284659739347
ko00310	Lysine degradation	4/1280	73/7206	0.00316972994085
ko04622	RIG-I-like receptor signaling pathway	3/1280	62/7206	0.00418417528159
ko03022	Basal transcription factors	1/1280	44/7206	0.00440486332583
ko05166	HTLV-I infection	34/1280	292/7206	0.00474799821398
ko04668	TNF signaling pathway	10/1280	120/7206	0.00521446396687
ko00590	Arachidonic acid metabolism	2/1280	52/7206	0.00539605856889
ko04912	GnRH signaling pathway	34/1280	122/7206	0.00559477571098
ko05145	Toxoplasmosis	11/1280	126/7206	0.00641557629346
ko04657	IL-17 signaling pathway	6/1280	87/7206	0.006639352486
ko03018	RNA degradation	6/1280	84/7206	0.00897968076509
ko04115	p53 signaling pathway	5/1280	74/7206	0.00905474932749
ko01524	Platinum drug resistance	5/1280	76/7206	0.00937207396691
ko00630	Glyoxylate and dicarboxylate metabolism	1/1280	38/7206	0.00938676063711
ko05131	Shigellosis	6/1280	82/7206	0.0124914902376
ko04922	Glucagon signaling pathway	34/1280	128/7206	0.0136125463351
ko00500	Starch and sucrose metabolism	1/1280	35/7206	0.0140723589444
ko04916	Melanogenesis	37/1280	142/7206	0.0140989261665
ko04658	Th1 and Th2 cell differentiation	8/1280	96/7206	0.0146581193052
ko04630	Jak-STAT signaling pathway	13/1280	132/7206	0.0152948471851
ko05133	Pertussis	7/1280	87/7206	0.0156227368251
ko05418	Fluid shear stress and atherosclerosis	19/1280	173/7206	0.0156462640047
ko00562	Inositol phosphate metabolism	25/1280	89/7206	0.0166319247508
ko04620	Toll-like receptor signaling pathway	9/1280	100/7206	0.0175926443007
ko04270	Vascular smooth muscle contraction	39/1280	154/7206	0.0184562844454
ko04978	Mineral absorption	13/1280	40/7206	0.0212037238439
ko05206	MicroRNAs in cancer	20/1280	177/7206	0.0217203163929
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1280	182/7206	0.0238541460941
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1280	100/7206	0.0239892343471
ko05217	Basal cell carcinoma	5/1280	68/7206	0.0242442319477
ko04015	Rap1 signaling pathway	64/1280	278/7206	0.0246810338792
ko05222	Small cell lung cancer	8/1280	89/7206	0.0256368227105
ko04640	Hematopoietic cell lineage	5/1280	64/7206	0.032810904361
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1280	40/7206	0.0356186907446
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1280	15/7206	0.036331714186
ko04350	TGF-beta signaling pathway	10/1280	103/7206	0.0365168850001
ko04217	Necroptosis	21/1280	178/7206	0.0365681281097
ko05231	Choline metabolism in cancer	33/1280	134/7206	0.0400138981808
ko04114	Oocyte meiosis	34/1280	139/7206	0.0432229457922
ko04330	Notch signaling pathway	5/1280	62/7206	0.0446983366385
ko00600	Sphingolipid metabolism	5/1280	63/7206	0.0451976356987
ko05132	Salmonella infection	10/1280	98/7206	0.0463914830229
ko05034	Alcoholism	54/1280	238/7206	0.0472079696443
ko05320	Autoimmune thyroid disease	1/1280	29/7206	0.0480267938917
ko00280	Valine, leucine and isoleucine degradation	4/1280	54/7206	0.0480686470574