ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1154	423/7206	2.4453347781e-52
ko04724	Glutamatergic synapse	92/1154	152/7206	2.36060876074e-36
ko05033	Nicotine addiction	50/1154	56/7206	8.23916565871e-34
ko05032	Morphine addiction	71/1154	110/7206	8.4209450178e-31
ko04727	GABAergic synapse	68/1154	110/7206	7.23121191528e-28
ko04713	Circadian entrainment	77/1154	136/7206	8.04004798949e-28
ko04728	Dopaminergic synapse	89/1154	185/7206	4.07736698102e-25
ko04725	Cholinergic synapse	77/1154	160/7206	7.31888568546e-22
ko04723	Retrograde endocannabinoid signaling	81/1154	175/7206	1.42174927601e-21
ko04721	Synaptic vesicle cycle	48/1154	80/7206	3.2499849682e-19
ko04024	cAMP signaling pathway	105/1154	279/7206	3.51250081183e-19
ko04911	Insulin secretion	57/1154	117/7206	8.78548649417e-17
ko04020	Calcium signaling pathway	95/1154	265/7206	8.43950424501e-16
ko04742	Taste transduction	37/1154	61/7206	2.5875633258e-15
ko04921	Oxytocin signaling pathway	78/1154	209/7206	3.14506111804e-14
ko04726	Serotonergic synapse	57/1154	137/7206	4.82115270616e-13
ko04744	Phototransduction	25/1154	36/7206	1.03162870016e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1154	205/7206	1.08282945301e-12
ko05031	Amphetamine addiction	42/1154	91/7206	1.02705921425e-11
ko04720	Long-term potentiation	44/1154	99/7206	1.61306418429e-11
ko03040	Spliceosome	1/1154	145/7206	3.22854689165e-10
ko04970	Salivary secretion	40/1154	95/7206	9.98733054654e-10
ko04360	Axon guidance	73/1154	233/7206	3.05147541289e-09
ko05030	Cocaine addiction	33/1154	73/7206	3.35012080433e-09
ko04925	Aldosterone synthesis and secretion	41/1154	105/7206	9.02603954144e-09
ko04971	Gastric acid secretion	39/1154	98/7206	1.11218583364e-08
ko05203	Viral carcinogenesis	15/1154	277/7206	5.92912553792e-08
ko04010	MAPK signaling pathway	87/1154	321/7206	2.1267889353e-07
ko04060	Cytokine-cytokine receptor interaction	8/1154	191/7206	3.6835719644e-07
ko04740	Olfactory transduction	31/1154	80/7206	7.15652633867e-07
ko05322	Systemic lupus erythematosus	5/1154	151/7206	8.87479630548e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1154	74/7206	1.23920716388e-06
ko04022	cGMP-PKG signaling pathway	62/1154	216/7206	1.77851161223e-06
ko03013	RNA transport	7/1154	166/7206	2.80263127794e-06
ko04972	Pancreatic secretion	37/1154	111/7206	5.39055004894e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1154	79/7206	1.90454657304e-05
ko05414	Dilated cardiomyopathy	36/1154	112/7206	2.067983428e-05
ko04070	Phosphatidylinositol signaling system	36/1154	112/7206	2.067983428e-05
ko05168	Herpes simplex infection	10/1154	182/7206	2.08232480937e-05
ko04072	Phospholipase D signaling pathway	53/1154	197/7206	7.16407886746e-05
ko04014	Ras signaling pathway	70/1154	279/7206	7.99121000533e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1154	59/7206	9.07016490818e-05
ko04260	Cardiac muscle contraction	31/1154	98/7206	0.00012601624434
ko04730	Long-term depression	26/1154	78/7206	0.000135387648166
ko04141	Protein processing in endoplasmic reticulum	12/1154	184/7206	0.000141541141138
ko04924	Renin secretion	28/1154	86/7206	0.000146010494127
ko04915	Estrogen signaling pathway	38/1154	131/7206	0.000155143672248
ko05110	Vibrio cholerae infection	22/1154	63/7206	0.000196411579451
ko04612	Antigen processing and presentation	2/1154	77/7206	0.000260294643581
ko03008	Ribosome biogenesis in eukaryotes	2/1154	79/7206	0.000272799571917
ko05164	Influenza A	11/1154	167/7206	0.000370661832662
ko05140	Leishmaniasis	2/1154	75/7206	0.000385707215323
ko04540	Gap junction	36/1154	128/7206	0.000552016813466
ko04976	Bile secretion	25/1154	80/7206	0.000592389184749
ko04514	Cell adhesion molecules (CAMs)	36/1154	130/7206	0.000632254454371
ko05205	Proteoglycans in cancer	24/1154	271/7206	0.000683050873208
ko04750	Inflammatory mediator regulation of TRP channels	34/1154	122/7206	0.000713653839747
ko04923	Regulation of lipolysis in adipocytes	24/1154	77/7206	0.000820734346632
ko00515	Mannose type O-glycan biosynthesis	11/1154	25/7206	0.000855681833144
ko04621	NOD-like receptor signaling pathway	11/1154	157/7206	0.000908505796577
ko05162	Measles	7/1154	120/7206	0.000996096399406
ko04371	Apelin signaling pathway	45/1154	177/7206	0.00117885582217
ko04966	Collecting duct acid secretion	11/1154	26/7206	0.0012710066309
ko04110	Cell cycle	10/1154	145/7206	0.00128412058536
ko00520	Amino sugar and nucleotide sugar metabolism	1/1154	55/7206	0.00132707548917
ko04745	Phototransduction - fly	14/1154	38/7206	0.00146891056745
ko04912	GnRH signaling pathway	33/1154	122/7206	0.00167431236042
ko04640	Hematopoietic cell lineage	2/1154	64/7206	0.00183465198653
ko04064	NF-kappa B signaling pathway	5/1154	96/7206	0.00184312986723
ko00590	Arachidonic acid metabolism	1/1154	52/7206	0.00198712983755
ko03018	RNA degradation	4/1154	84/7206	0.002455993266
ko04120	Ubiquitin mediated proteolysis	10/1154	138/7206	0.00314797558711
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1154	14/7206	0.00321989198343
ko00240	Pyrimidine metabolism	7/1154	110/7206	0.00361571208315
ko04918	Thyroid hormone synthesis	24/1154	86/7206	0.00454008184109
ko00260	Glycine, serine and threonine metabolism	1/1154	48/7206	0.00461792012809
ko05169	Epstein-Barr virus infection	19/1154	206/7206	0.00512565282689
ko04146	Peroxisome	5/1154	89/7206	0.0051434313122
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	7/1154	15/7206	0.00521138050896
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1154	100/7206	0.00542533130623
ko05321	Inflammatory bowel disease (IBD)	2/1154	56/7206	0.00579172319231
ko03022	Basal transcription factors	1/1154	44/7206	0.00672994931161
ko05144	Malaria	1/1154	45/7206	0.00681348137329
ko00071	Fatty acid degradation	1/1154	45/7206	0.00681348137329
ko03420	Nucleotide excision repair	1/1154	46/7206	0.00713782057816
ko00480	Glutathione metabolism	2/1154	55/7206	0.00857177098383
ko04670	Leukocyte transendothelial migration	13/1154	151/7206	0.00970299904762
ko05161	Hepatitis B	16/1154	173/7206	0.0116415251704
ko00330	Arginine and proline metabolism	3/1154	61/7206	0.0133346419763
ko04930	Type II diabetes mellitus	16/1154	54/7206	0.0135137121452
ko04916	Melanogenesis	34/1154	142/7206	0.0145500256614
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1154	40/7206	0.0153180202133
ko04964	Proximal tubule bicarbonate reclamation	10/1154	29/7206	0.0178356248685
ko00562	Inositol phosphate metabolism	23/1154	89/7206	0.0186887202256
ko04062	Chemokine signaling pathway	45/1154	201/7206	0.0187018279405
ko04015	Rap1 signaling pathway	59/1154	278/7206	0.0192871976319
ko03320	PPAR signaling pathway	4/1154	69/7206	0.0194319567483
ko04350	TGF-beta signaling pathway	8/1154	103/7206	0.0205753207964
ko00982	Drug metabolism - cytochrome P450	1/1154	37/7206	0.0225951113048
ko00630	Glyoxylate and dicarboxylate metabolism	1/1154	38/7206	0.0234036858776
ko04115	p53 signaling pathway	5/1154	74/7206	0.0253496537288
ko05202	Transcriptional misregulation in cancer	19/1154	188/7206	0.0260804858465
ko04114	Oocyte meiosis	32/1154	139/7206	0.0265270733529
ko04722	Neurotrophin signaling pathway	36/1154	160/7206	0.0288211488151
ko05016	Huntington's disease	23/1154	215/7206	0.0297421188218
ko00513	Various types of N-glycan biosynthesis	12/1154	42/7206	0.0339495336578
ko04973	Carbohydrate digestion and absorption	12/1154	42/7206	0.0339495336578
ko04213	Longevity regulating pathway - multiple species	21/1154	86/7206	0.0381649290456
ko01200	Carbon metabolism	12/1154	128/7206	0.0383304970939
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1154	182/7206	0.0400364902393
ko04711	Circadian rhythm - fly	5/1154	13/7206	0.0438225271462
ko04962	Vasopressin-regulated water reabsorption	15/1154	58/7206	0.0474826362218
ko04136	Autophagy - other	1/1154	31/7206	0.0495922884225
ko04210	Apoptosis	19/1154	180/7206	0.0496953556187