ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	167/1009	423/7206	2.68975122358e-41
ko04724	Glutamatergic synapse	82/1009	152/7206	7.59747154323e-32
ko05033	Nicotine addiction	44/1009	56/7206	1.22201695797e-27
ko04721	Synaptic vesicle cycle	52/1009	80/7206	7.12332209852e-26
ko05032	Morphine addiction	62/1009	110/7206	1.08526845829e-25
ko04727	GABAergic synapse	60/1009	110/7206	7.11309748406e-24
ko04728	Dopaminergic synapse	80/1009	185/7206	7.7786071528e-23
ko04713	Circadian entrainment	66/1009	136/7206	2.14200648227e-22
ko04725	Cholinergic synapse	72/1009	160/7206	6.96791752343e-22
ko04723	Retrograde endocannabinoid signaling	72/1009	175/7206	3.79962329141e-19
ko04911	Insulin secretion	53/1009	117/7206	1.49193876535e-16
ko04024	cAMP signaling pathway	89/1009	279/7206	4.87958797373e-15
ko04726	Serotonergic synapse	55/1009	137/7206	2.39835801688e-14
ko04742	Taste transduction	33/1009	61/7206	1.5387014452e-13
ko04921	Oxytocin signaling pathway	70/1009	209/7206	3.32309104383e-13
ko04020	Calcium signaling pathway	82/1009	265/7206	4.17113491836e-13
ko04744	Phototransduction	23/1009	36/7206	6.85895801585e-12
ko05031	Amphetamine addiction	39/1009	91/7206	1.37984781562e-11
ko04720	Long-term potentiation	40/1009	99/7206	6.95963405883e-11
ko04261	Adrenergic signaling in cardiomyocytes	63/1009	205/7206	4.8706098627e-10
ko03040	Spliceosome	1/1009	145/7206	9.17961261328e-09
ko05203	Viral carcinogenesis	12/1009	277/7206	1.27809307813e-07
ko04971	Gastric acid secretion	34/1009	98/7206	1.68503894186e-07
ko04360	Axon guidance	62/1009	233/7206	2.35904874328e-07
ko04966	Collecting duct acid secretion	15/1009	26/7206	2.40172983463e-07
ko04970	Salivary secretion	33/1009	95/7206	2.47463394226e-07
ko04120	Ubiquitin mediated proteolysis	2/1009	138/7206	3.50747359207e-07
ko04925	Aldosterone synthesis and secretion	35/1009	105/7206	4.56484967551e-07
ko05030	Cocaine addiction	27/1009	73/7206	7.40429016769e-07
ko05168	Herpes simplex infection	6/1009	182/7206	2.1006946962e-06
ko04010	MAPK signaling pathway	76/1009	321/7206	2.11571614872e-06
ko05164	Influenza A	5/1009	167/7206	2.40350710072e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1009	74/7206	3.64030053319e-06
ko05322	Systemic lupus erythematosus	4/1009	151/7206	4.05396188372e-06
ko04514	Cell adhesion molecules (CAMs)	38/1009	130/7206	4.92273968121e-06
ko04740	Olfactory transduction	27/1009	80/7206	5.70527008941e-06
ko04621	NOD-like receptor signaling pathway	5/1009	157/7206	7.27401099776e-06
ko04060	Cytokine-cytokine receptor interaction	8/1009	191/7206	1.11787079009e-05
ko03013	RNA transport	6/1009	166/7206	1.25136610565e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1009	79/7206	2.04012206428e-05
ko04745	Phototransduction - fly	16/1009	38/7206	2.07919898363e-05
ko04972	Pancreatic secretion	33/1009	111/7206	2.09718607071e-05
ko04141	Protein processing in endoplasmic reticulum	8/1009	184/7206	2.21537406412e-05
ko04730	Long-term depression	25/1009	78/7206	4.16240397982e-05
ko04070	Phosphatidylinositol signaling system	32/1009	112/7206	4.76099774434e-05
ko04022	cGMP-PKG signaling pathway	52/1009	216/7206	5.67427112104e-05
ko05110	Vibrio cholerae infection	21/1009	63/7206	7.58851885748e-05
ko04014	Ras signaling pathway	63/1009	279/7206	9.37958009585e-05
ko04260	Cardiac muscle contraction	28/1009	98/7206	0.000169800224195
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1009	59/7206	0.00040617195607
ko04540	Gap junction	33/1009	128/7206	0.000416383807447
ko04072	Phospholipase D signaling pathway	45/1009	197/7206	0.000768546224333
ko05414	Dilated cardiomyopathy	29/1009	112/7206	0.000809425871538
ko05205	Proteoglycans in cancer	20/1009	271/7206	0.000891356919948
ko03008	Ribosome biogenesis in eukaryotes	2/1009	79/7206	0.000959137116277
ko04612	Antigen processing and presentation	2/1009	77/7206	0.00140981711904
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1009	14/7206	0.00144235538888
ko04750	Inflammatory mediator regulation of TRP channels	30/1009	122/7206	0.00145687224028
ko05169	Epstein-Barr virus infection	14/1009	206/7206	0.00149081749082
ko04924	Renin secretion	23/1009	86/7206	0.00153597542524
ko04626	Plant-pathogen interaction	8/1009	18/7206	0.00170613957608
ko05161	Hepatitis B	11/1009	173/7206	0.00183226424766
ko05162	Measles	6/1009	120/7206	0.00211833968147
ko04630	Jak-STAT signaling pathway	7/1009	132/7206	0.00214118556554
ko05166	HTLV-I infection	24/1009	292/7206	0.00252218976837
ko04064	NF-kappa B signaling pathway	4/1009	96/7206	0.00273516674048
ko04915	Estrogen signaling pathway	31/1009	131/7206	0.00309851919522
ko04964	Proximal tubule bicarbonate reclamation	10/1009	29/7206	0.00443496847442
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1009	182/7206	0.00477897365182
ko04110	Cell cycle	9/1009	145/7206	0.00500718499996
ko00480	Glutathione metabolism	1/1009	55/7206	0.00513436954687
ko04146	Peroxisome	4/1009	89/7206	0.00540668390035
ko04640	Hematopoietic cell lineage	2/1009	64/7206	0.00634306313086
ko04270	Vascular smooth muscle contraction	34/1009	154/7206	0.00646746650164
ko05140	Leishmaniasis	3/1009	75/7206	0.00717138262062
ko01524	Platinum drug resistance	3/1009	76/7206	0.0071797291296
ko00590	Arachidonic acid metabolism	1/1009	52/7206	0.00761137591639
ko04912	GnRH signaling pathway	28/1009	122/7206	0.00781659715666
ko04976	Bile secretion	20/1009	80/7206	0.00849547468696
ko00330	Arginine and proline metabolism	2/1009	61/7206	0.00918971788042
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1009	92/7206	0.00950542676696
ko04916	Melanogenesis	31/1009	142/7206	0.00988998081617
ko00310	Lysine degradation	3/1009	73/7206	0.0101916173779
ko00260	Glycine, serine and threonine metabolism	1/1009	48/7206	0.01097622402
ko04371	Apelin signaling pathway	37/1009	177/7206	0.0111701633119
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1009	100/7206	0.0131101153272
ko00562	Inositol phosphate metabolism	21/1009	89/7206	0.0131954728811
ko03022	Basal transcription factors	1/1009	44/7206	0.0162523485886
ko05144	Malaria	1/1009	45/7206	0.0162667373252
ko00071	Fatty acid degradation	1/1009	45/7206	0.0162667373252
ko04668	TNF signaling pathway	8/1009	120/7206	0.0164979336986
ko03420	Nucleotide excision repair	1/1009	46/7206	0.0166679058571
ko05321	Inflammatory bowel disease (IBD)	2/1009	56/7206	0.0191302770938
ko00140	Steroid hormone biosynthesis	1/1009	41/7206	0.0240650989218
ko04114	Oocyte meiosis	29/1009	139/7206	0.0254349380772
ko05145	Toxoplasmosis	9/1009	126/7206	0.0265905502171
ko04015	Rap1 signaling pathway	52/1009	278/7206	0.0270893058828
ko00280	Valine, leucine and isoleucine degradation	2/1009	54/7206	0.0279696394586
ko04217	Necroptosis	15/1009	178/7206	0.0284066039897
ko04210	Apoptosis	15/1009	180/7206	0.0287910434617
ko04062	Chemokine signaling pathway	39/1009	201/7206	0.0300554000868
ko03410	Base excision repair	1/1009	38/7206	0.035551360229
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1009	40/7206	0.0362804661935
ko05131	Shigellosis	5/1009	82/7206	0.036629662191
ko04137	Mitophagy - animal	5/1009	82/7206	0.036629662191
ko00240	Pyrimidine metabolism	8/1009	110/7206	0.0377302395075
ko05215	Prostate cancer	8/1009	111/7206	0.0378248250253
ko04214	Apoptosis - fly	4/1009	72/7206	0.0389213667132
ko00380	Tryptophan metabolism	2/1009	50/7206	0.0393110011648
ko04973	Carbohydrate digestion and absorption	11/1009	42/7206	0.0400745093894
ko04140	Autophagy - animal	14/1009	164/7206	0.0402641323276
ko04622	RIG-I-like receptor signaling pathway	3/1009	62/7206	0.0406643259511
ko00680	Methane metabolism	9/1009	34/7206	0.0457768297913
ko04930	Type II diabetes mellitus	13/1009	54/7206	0.0459293396118
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/1009	15/7206	0.0476934225137