ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	113/583	423/7206	7.08949822998e-33
ko04724	Glutamatergic synapse	64/583	152/7206	3.68313322994e-31
ko05033	Nicotine addiction	38/583	56/7206	5.43307418879e-29
ko04727	GABAergic synapse	46/583	110/7206	1.85584716158e-22
ko05032	Morphine addiction	45/583	110/7206	1.60912895105e-21
ko04723	Retrograde endocannabinoid signaling	55/583	175/7206	1.14244288969e-19
ko04728	Dopaminergic synapse	55/583	185/7206	2.01949641896e-18
ko04713	Circadian entrainment	44/583	136/7206	1.82712125646e-16
ko04725	Cholinergic synapse	47/583	160/7206	1.16685785289e-15
ko04024	cAMP signaling pathway	65/583	279/7206	1.2094254886e-15
ko04020	Calcium signaling pathway	57/583	265/7206	2.84801270286e-12
ko04911	Insulin secretion	35/583	117/7206	3.26189185108e-12
ko04721	Synaptic vesicle cycle	28/583	80/7206	7.42014889366e-12
ko05030	Cocaine addiction	26/583	73/7206	2.67917259583e-11
ko04261	Adrenergic signaling in cardiomyocytes	46/583	205/7206	9.05915741663e-11
ko04742	Taste transduction	23/583	61/7206	1.00274398456e-10
ko04921	Oxytocin signaling pathway	46/583	209/7206	1.81175320514e-10
ko04726	Serotonergic synapse	35/583	137/7206	4.3113525128e-10
ko05031	Amphetamine addiction	26/583	91/7206	6.2802712682e-09
ko04514	Cell adhesion molecules (CAMs)	31/583	130/7206	2.57812048589e-08
ko04720	Long-term potentiation	26/583	99/7206	4.29866429033e-08
ko04970	Salivary secretion	25/583	95/7206	7.50744969673e-08
ko04010	MAPK signaling pathway	53/583	321/7206	4.96711892743e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	19/583	74/7206	4.15394351869e-06
ko04972	Pancreatic secretion	24/583	111/7206	6.28382302458e-06
ko04072	Phospholipase D signaling pathway	35/583	197/7206	7.25354994283e-06
ko04925	Aldosterone synthesis and secretion	23/583	105/7206	7.78227108684e-06
ko04730	Long-term depression	19/583	78/7206	9.57071899109e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/583	79/7206	1.16688591269e-05
ko04915	Estrogen signaling pathway	26/583	131/7206	1.34911865268e-05
ko05414	Dilated cardiomyopathy	23/583	112/7206	2.38255383472e-05
ko04260	Cardiac muscle contraction	20/583	98/7206	8.80658473552e-05
ko04971	Gastric acid secretion	20/583	98/7206	8.80658473552e-05
ko04060	Cytokine-cytokine receptor interaction	3/583	191/7206	0.000134418718438
ko03040	Spliceosome	1/583	145/7206	0.000144209492383
ko05203	Viral carcinogenesis	7/583	277/7206	0.000169740024686
ko04022	cGMP-PKG signaling pathway	34/583	216/7206	0.000181497868234
ko04540	Gap junction	23/583	128/7206	0.000225240492985
ko03013	RNA transport	3/583	166/7206	0.000803752813021
ko04360	Axon guidance	34/583	233/7206	0.000826177241941
ko04120	Ubiquitin mediated proteolysis	2/583	138/7206	0.00133568037298
ko05322	Systemic lupus erythematosus	3/583	151/7206	0.00229507223914
ko05410	Hypertrophic cardiomyopathy (HCM)	17/583	100/7206	0.00272309160161
ko01200	Carbon metabolism	2/583	128/7206	0.00276354518052
ko04350	TGF-beta signaling pathway	1/583	103/7206	0.00298973853251
ko04930	Type II diabetes mellitus	11/583	54/7206	0.00341703474518
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/583	14/7206	0.0036822490891
ko04141	Protein processing in endoplasmic reticulum	5/583	184/7206	0.00372547147497
ko05205	Proteoglycans in cancer	10/583	271/7206	0.00433679696889
ko04750	Inflammatory mediator regulation of TRP channels	19/583	122/7206	0.00624023971779
ko04961	Endocrine and other factor-regulated calcium reabsorption	11/583	59/7206	0.00691418524983
ko04621	NOD-like receptor signaling pathway	4/583	157/7206	0.00697022993307
ko05168	Herpes simplex infection	6/583	182/7206	0.0125888182969
ko04110	Cell cycle	4/583	145/7206	0.0130141540162
ko03018	RNA degradation	1/583	84/7206	0.0137977966702
ko04924	Renin secretion	14/583	86/7206	0.0144746540193
ko04918	Thyroid hormone synthesis	14/583	86/7206	0.0144746540193
ko04612	Antigen processing and presentation	1/583	77/7206	0.0196790246041
ko03008	Ribosome biogenesis in eukaryotes	1/583	79/7206	0.0200701420616
ko04015	Rap1 signaling pathway	33/583	278/7206	0.0242264632699
ko02024	Quorum sensing	4/583	15/7206	0.0281879307989
ko04214	Apoptosis - fly	1/583	72/7206	0.0285834651601
ko00010	Glycolysis / Gluconeogenesis	1/583	74/7206	0.0291431160925
ko05164	Influenza A	6/583	167/7206	0.0300314199559
ko04923	Regulation of lipolysis in adipocytes	12/583	77/7206	0.0314284189585
ko04976	Bile secretion	12/583	80/7206	0.0354686040811
ko04217	Necroptosis	7/583	178/7206	0.0363846718593
ko04218	Cellular senescence	7/583	177/7206	0.0364013695712
ko04932	Non-alcoholic fatty liver disease (NAFLD)	7/583	182/7206	0.037257369404
ko03320	PPAR signaling pathway	1/583	69/7206	0.0422364207441
ko01230	Biosynthesis of amino acids	2/583	85/7206	0.0454706870281
ko00190	Oxidative phosphorylation	4/583	127/7206	0.0461712655395
ko00515	Mannose type O-glycan biosynthesis	5/583	25/7206	0.0467239065567
ko04146	Peroxisome	2/583	89/7206	0.0469091305523
ko05010	Alzheimer's disease	24/583	202/7206	0.0496261586412