ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	211/1272	423/7206	1.03536591713e-55
ko04724	Glutamatergic synapse	92/1272	152/7206	8.1042248569e-33
ko05032	Morphine addiction	71/1272	110/7206	4.88861431792e-28
ko04713	Circadian entrainment	80/1272	136/7206	1.92137693701e-27
ko05033	Nicotine addiction	47/1272	56/7206	2.84061256782e-27
ko04727	GABAergic synapse	69/1272	110/7206	3.59664225665e-26
ko04728	Dopaminergic synapse	88/1272	185/7206	2.29915230952e-21
ko04725	Cholinergic synapse	79/1272	160/7206	1.52282415912e-20
ko04721	Synaptic vesicle cycle	51/1272	80/7206	4.27497256571e-20
ko04024	cAMP signaling pathway	113/1272	279/7206	4.53289705435e-20
ko04020	Calcium signaling pathway	109/1272	265/7206	7.90118088884e-20
ko04723	Retrograde endocannabinoid signaling	80/1272	175/7206	3.34882341313e-18
ko04911	Insulin secretion	61/1272	117/7206	1.33102068066e-17
ko04726	Serotonergic synapse	65/1272	137/7206	5.36396136786e-16
ko04742	Taste transduction	39/1272	61/7206	1.0114424954e-15
ko04921	Oxytocin signaling pathway	85/1272	209/7206	1.86510992133e-15
ko04970	Salivary secretion	48/1272	95/7206	1.93074310242e-13
ko04744	Phototransduction	25/1272	36/7206	9.80975643074e-12
ko04261	Adrenergic signaling in cardiomyocytes	76/1272	205/7206	2.0149260335e-11
ko03040	Spliceosome	1/1272	145/7206	2.6039237271e-11
ko04720	Long-term potentiation	46/1272	99/7206	2.69322683872e-11
ko05031	Amphetamine addiction	43/1272	91/7206	6.07156554848e-11
ko04022	cGMP-PKG signaling pathway	76/1272	216/7206	3.17047801534e-10
ko04925	Aldosterone synthesis and secretion	46/1272	105/7206	3.19645844004e-10
ko04740	Olfactory transduction	37/1272	80/7206	2.81969741268e-09
ko04971	Gastric acid secretion	42/1272	98/7206	4.26546205171e-09
ko05203	Viral carcinogenesis	17/1272	277/7206	1.83494341844e-08
ko03013	RNA transport	7/1272	166/7206	2.53758485595e-07
ko05168	Herpes simplex infection	9/1272	182/7206	3.39404941423e-07
ko05322	Systemic lupus erythematosus	6/1272	151/7206	4.2545514326e-07
ko04924	Renin secretion	35/1272	86/7206	4.3739166829e-07
ko04360	Axon guidance	72/1272	233/7206	4.76036657908e-07
ko04540	Gap junction	46/1272	128/7206	8.43638099206e-07
ko04972	Pancreatic secretion	41/1272	111/7206	1.00462521249e-06
ko04976	Bile secretion	32/1272	80/7206	2.07652643109e-06
ko05030	Cocaine addiction	30/1272	73/7206	2.69388014841e-06
ko04730	Long-term depression	31/1272	78/7206	3.48879589211e-06
ko05164	Influenza A	9/1272	167/7206	4.30680983772e-06
ko04060	Cytokine-cytokine receptor interaction	12/1272	191/7206	4.8106559455e-06
ko04966	Collecting duct acid secretion	15/1272	26/7206	5.1098065124e-06
ko04010	MAPK signaling pathway	88/1272	321/7206	8.65242515297e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1272	74/7206	9.82459189349e-06
ko04070	Phosphatidylinositol signaling system	39/1272	112/7206	1.35847932038e-05
ko04120	Ubiquitin mediated proteolysis	7/1272	138/7206	1.40824766116e-05
ko04621	NOD-like receptor signaling pathway	9/1272	157/7206	1.70755732198e-05
ko04514	Cell adhesion molecules (CAMs)	43/1272	130/7206	2.03509021174e-05
ko04964	Proximal tubule bicarbonate reclamation	15/1272	29/7206	3.01395271905e-05
ko05110	Vibrio cholerae infection	25/1272	63/7206	3.42078693432e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1272	59/7206	3.62599739941e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1272	122/7206	5.66381319725e-05
ko05169	Epstein-Barr virus infection	16/1272	206/7206	5.72908747698e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1272	79/7206	7.22297608911e-05
ko04110	Cell cycle	9/1272	145/7206	9.36685645346e-05
ko04745	Phototransduction - fly	17/1272	38/7206	9.61820514509e-05
ko04923	Regulation of lipolysis in adipocytes	28/1272	77/7206	0.00011122165753
ko04141	Protein processing in endoplasmic reticulum	14/1272	184/7206	0.000115348679295
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1272	79/7206	0.000142724223579
ko05414	Dilated cardiomyopathy	36/1272	112/7206	0.000153804762378
ko04014	Ras signaling pathway	74/1272	279/7206	0.000155454422825
ko04371	Apelin signaling pathway	51/1272	177/7206	0.000197770052338
ko04072	Phospholipase D signaling pathway	55/1272	197/7206	0.000287730752192
ko04612	Antigen processing and presentation	3/1272	77/7206	0.000443513356529
ko04064	NF-kappa B signaling pathway	5/1272	96/7206	0.000609771083516
ko05162	Measles	8/1272	120/7206	0.000647997251286
ko05140	Leishmaniasis	3/1272	75/7206	0.000652166301422
ko04260	Cardiac muscle contraction	31/1272	98/7206	0.000709266058657
ko04915	Estrogen signaling pathway	38/1272	131/7206	0.00112079868289
ko04146	Peroxisome	5/1272	89/7206	0.00118352197518
ko05205	Proteoglycans in cancer	29/1272	271/7206	0.00150071548768
ko04626	Plant-pathogen interaction	9/1272	18/7206	0.00170392723407
ko04710	Circadian rhythm	16/1272	43/7206	0.00201915921224
ko00071	Fatty acid degradation	1/1272	45/7206	0.00273289927532
ko04217	Necroptosis	17/1272	178/7206	0.00274902254882
ko03420	Nucleotide excision repair	1/1272	46/7206	0.00281650723258
ko04922	Glucagon signaling pathway	36/1272	128/7206	0.0031815320335
ko00310	Lysine degradation	4/1272	73/7206	0.0031996377962
ko00480	Glutathione metabolism	2/1272	55/7206	0.00373214944078
ko04330	Notch signaling pathway	3/1272	62/7206	0.0042208000002
ko04622	RIG-I-like receptor signaling pathway	3/1272	62/7206	0.0042208000002
ko03022	Basal transcription factors	1/1272	44/7206	0.00434384658634
ko05161	Hepatitis B	17/1272	173/7206	0.0046068048372
ko04270	Vascular smooth muscle contraction	41/1272	154/7206	0.00517955911338
ko00590	Arachidonic acid metabolism	2/1272	52/7206	0.00537519464406
ko00330	Arginine and proline metabolism	3/1272	61/7206	0.00615283425302
ko05145	Toxoplasmosis	11/1272	126/7206	0.00637463837308
ko05133	Pertussis	6/1272	87/7206	0.0065545676415
ko04610	Complement and coagulation cascades	5/1272	79/7206	0.00678501495239
ko00240	Pyrimidine metabolism	9/1272	110/7206	0.00758977949711
ko04630	Jak-STAT signaling pathway	12/1272	132/7206	0.00768735805168
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1272	182/7206	0.00774878698043
ko04912	GnRH signaling pathway	33/1272	122/7206	0.00827626330887
ko03018	RNA degradation	6/1272	84/7206	0.00892155819957
ko03410	Base excision repair	1/1272	38/7206	0.0094005488905
ko04916	Melanogenesis	37/1272	142/7206	0.0104217442845
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1272	100/7206	0.0112876625598
ko05131	Shigellosis	6/1272	82/7206	0.0123593295795
ko05321	Inflammatory bowel disease (IBD)	3/1272	56/7206	0.0126051789166
ko04214	Apoptosis - fly	5/1272	72/7206	0.0126280361041
ko04115	p53 signaling pathway	5/1272	74/7206	0.0130505340597
ko04658	Th1 and Th2 cell differentiation	8/1272	96/7206	0.014552766116
ko05166	HTLV-I infection	36/1272	292/7206	0.0148856432346
ko04918	Thyroid hormone synthesis	24/1272	86/7206	0.0155298862101
ko04657	IL-17 signaling pathway	7/1272	87/7206	0.0155973269937
ko00562	Inositol phosphate metabolism	25/1272	89/7206	0.0163126524332
ko04711	Circadian rhythm - fly	6/1272	13/7206	0.0166165469624
ko05144	Malaria	2/1272	45/7206	0.0169321427201
ko00280	Valine, leucine and isoleucine degradation	3/1272	54/7206	0.0181967452907
ko04015	Rap1 signaling pathway	64/1272	278/7206	0.0198081280728
ko05231	Choline metabolism in cancer	34/1272	134/7206	0.0219268946311
ko01524	Platinum drug resistance	6/1272	76/7206	0.0226187597319
ko04620	Toll-like receptor signaling pathway	9/1272	100/7206	0.0237116897578
ko03320	PPAR signaling pathway	5/1272	69/7206	0.0247209933063
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1272	14/7206	0.024817623997
ko00380	Tryptophan metabolism	3/1272	50/7206	0.0253355937194
ko04930	Type II diabetes mellitus	16/1272	54/7206	0.029716644169
ko05215	Prostate cancer	11/1272	111/7206	0.0321468189108
ko05222	Small cell lung cancer	8/1272	89/7206	0.0345519215447
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1272	40/7206	0.0355265282934
ko05219	Bladder cancer	3/1272	48/7206	0.0358336745152
ko04210	Apoptosis	21/1272	180/7206	0.0369439674597
ko04973	Carbohydrate digestion and absorption	13/1272	42/7206	0.0389749049873
ko05016	Huntington's disease	27/1272	215/7206	0.0458395203221
ko04640	Hematopoietic cell lineage	5/1272	64/7206	0.045996103154