ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	138/830	423/7206	3.2191963924e-33
ko05033	Nicotine addiction	42/830	56/7206	1.75507253343e-28
ko04724	Glutamatergic synapse	70/830	152/7206	3.42759754684e-27
ko04713	Circadian entrainment	60/830	136/7206	3.13172374436e-22
ko05032	Morphine addiction	51/830	110/7206	3.11460619394e-20
ko04728	Dopaminergic synapse	68/830	185/7206	1.0509415802e-19
ko04727	GABAergic synapse	49/830	110/7206	1.43932427736e-18
ko04020	Calcium signaling pathway	78/830	265/7206	6.0753157492e-16
ko04723	Retrograde endocannabinoid signaling	59/830	175/7206	3.18388803353e-15
ko04024	cAMP signaling pathway	79/830	279/7206	5.06407567152e-15
ko04725	Cholinergic synapse	53/830	160/7206	1.94461606884e-13
ko04721	Synaptic vesicle cycle	34/830	80/7206	1.53765461646e-12
ko04921	Oxytocin signaling pathway	61/830	209/7206	1.63056190155e-12
ko04911	Insulin secretion	41/830	117/7206	1.46863184259e-11
ko04726	Serotonergic synapse	45/830	137/7206	1.88216088827e-11
ko05031	Amphetamine addiction	35/830	91/7206	2.27750437949e-11
ko04720	Long-term potentiation	35/830	99/7206	3.53348649309e-10
ko04261	Adrenergic signaling in cardiomyocytes	54/830	205/7206	2.40143811719e-09
ko04970	Salivary secretion	32/830	95/7206	8.03009639104e-09
ko04742	Taste transduction	22/830	61/7206	4.62054511156e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	24/830	74/7206	1.31373025945e-06
ko04745	Phototransduction - fly	16/830	38/7206	1.58735999365e-06
ko04740	Olfactory transduction	25/830	80/7206	1.72339876271e-06
ko04022	cGMP-PKG signaling pathway	49/830	216/7206	2.14945146454e-06
ko05203	Viral carcinogenesis	10/830	277/7206	3.03396342403e-06
ko04730	Long-term depression	24/830	78/7206	3.76662103728e-06
ko05030	Cocaine addiction	23/830	73/7206	3.81872099411e-06
ko04744	Phototransduction	15/830	36/7206	3.95476626431e-06
ko03010	Ribosome	1/830	129/7206	4.29537886686e-06
ko04925	Aldosterone synthesis and secretion	29/830	105/7206	6.72972004906e-06
ko04070	Phosphatidylinositol signaling system	30/830	112/7206	6.89529106174e-06
ko04971	Gastric acid secretion	27/830	98/7206	1.54224517699e-05
ko05322	Systemic lupus erythematosus	3/830	151/7206	2.48407532284e-05
ko04010	MAPK signaling pathway	61/830	321/7206	7.09065126639e-05
ko04120	Ubiquitin mediated proteolysis	3/830	138/7206	7.40971674041e-05
ko04360	Axon guidance	47/830	233/7206	9.61431623689e-05
ko05164	Influenza A	5/830	167/7206	0.000111940901648
ko04072	Phospholipase D signaling pathway	41/830	197/7206	0.000151361878855
ko04060	Cytokine-cytokine receptor interaction	7/830	191/7206	0.000192680527324
ko04710	Circadian rhythm	14/830	43/7206	0.000204781493926
ko04540	Gap junction	29/830	128/7206	0.000360541165225
ko04514	Cell adhesion molecules (CAMs)	29/830	130/7206	0.000411157241689
ko04626	Plant-pathogen interaction	8/830	18/7206	0.00045421084185
ko03013	RNA transport	6/830	166/7206	0.00048151132943
ko05169	Epstein-Barr virus infection	9/830	206/7206	0.00051735260412
ko04750	Inflammatory mediator regulation of TRP channels	27/830	122/7206	0.000795007715043
ko04630	Jak-STAT signaling pathway	4/830	132/7206	0.000795049171495
ko04972	Pancreatic secretion	25/830	111/7206	0.0008077450905
ko04924	Renin secretion	21/830	86/7206	0.000887002212988
ko04621	NOD-like receptor signaling pathway	6/830	157/7206	0.000913402095675
ko00562	Inositol phosphate metabolism	21/830	89/7206	0.00115493753232
ko05168	Herpes simplex infection	8/830	182/7206	0.0013199413329
ko04014	Ras signaling pathway	50/830	279/7206	0.00147395115122
ko04260	Cardiac muscle contraction	22/830	98/7206	0.00199155664166
ko05162	Measles	4/830	120/7206	0.00219865505043
ko05161	Hepatitis B	8/830	173/7206	0.00236707384082
ko04350	TGF-beta signaling pathway	3/830	103/7206	0.0027935802569
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/830	14/7206	0.00304189230826
ko04141	Protein processing in endoplasmic reticulum	9/830	184/7206	0.00314234249572
ko04110	Cell cycle	6/830	145/7206	0.00341633545829
ko04964	Proximal tubule bicarbonate reclamation	9/830	29/7206	0.00404019132537
ko04064	NF-kappa B signaling pathway	3/830	96/7206	0.00563436078014
ko00240	Pyrimidine metabolism	4/830	110/7206	0.00609018135349
ko05215	Prostate cancer	4/830	111/7206	0.00621824574216
ko05166	HTLV-I infection	20/830	292/7206	0.00863958504469
ko05140	Leishmaniasis	2/830	75/7206	0.0101205689707
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	17/830	79/7206	0.0113960702617
ko04711	Circadian rhythm - fly	5/830	13/7206	0.0116712186872
ko04915	Estrogen signaling pathway	25/830	131/7206	0.0119288520189
ko04550	Signaling pathways regulating pluripotency of stem cells	9/830	165/7206	0.0128527850508
ko05010	Alzheimer's disease	35/830	202/7206	0.0133251459051
ko04214	Apoptosis - fly	2/830	72/7206	0.0145851348867
ko04922	Glucagon signaling pathway	24/830	128/7206	0.016407466328
ko00480	Glutathione metabolism	1/830	55/7206	0.017821369719
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/830	59/7206	0.0211887965638
ko04114	Oocyte meiosis	25/830	139/7206	0.0217697911157
ko05200	Pathways in cancer	41/830	492/7206	0.0230312766598
ko04722	Neurotrophin signaling pathway	28/830	160/7206	0.0232712352506
ko04966	Collecting duct acid secretion	7/830	26/7206	0.024188860015
ko05110	Vibrio cholerae infection	13/830	63/7206	0.0292422064963
ko04371	Apelin signaling pathway	30/830	177/7206	0.030835071384
ko04610	Complement and coagulation cascades	3/830	79/7206	0.0312526230952
ko05205	Proteoglycans in cancer	20/830	271/7206	0.0321889698527
ko05034	Alcoholism	38/830	238/7206	0.0380771940265
ko05219	Bladder cancer	1/830	48/7206	0.0383746902563
ko04212	Longevity regulating pathway - worm	4/830	87/7206	0.0413542321363
ko05222	Small cell lung cancer	4/830	89/7206	0.0425224613404
ko04330	Notch signaling pathway	2/830	62/7206	0.0427424249506
ko01524	Platinum drug resistance	3/830	76/7206	0.0439895051564
ko04960	Aldosterone-regulated sodium reabsorption	9/830	41/7206	0.0468703729618
ko05202	Transcriptional misregulation in cancer	13/830	188/7206	0.0482182117139