ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	156/859	423/7206	2.10321294205e-43
ko04724	Glutamatergic synapse	79/859	152/7206	3.01906266592e-34
ko05033	Nicotine addiction	46/859	56/7206	1.20007501482e-33
ko04727	GABAergic synapse	57/859	110/7206	7.7001666301e-25
ko05032	Morphine addiction	57/859	110/7206	7.7001666301e-25
ko04728	Dopaminergic synapse	71/859	185/7206	6.43178423533e-21
ko04723	Retrograde endocannabinoid signaling	68/859	175/7206	2.01285512901e-20
ko04713	Circadian entrainment	57/859	136/7206	3.98590562096e-19
ko04721	Synaptic vesicle cycle	42/859	80/7206	7.0988511299e-19
ko04725	Cholinergic synapse	60/859	160/7206	2.92116806069e-17
ko04024	cAMP signaling pathway	82/859	279/7206	1.08521085929e-15
ko04911	Insulin secretion	45/859	117/7206	1.05239950157e-13
ko04742	Taste transduction	30/859	61/7206	7.30496175829e-13
ko04726	Serotonergic synapse	47/859	137/7206	3.91656804546e-12
ko04720	Long-term potentiation	38/859	99/7206	9.72970041376e-12
ko05031	Amphetamine addiction	34/859	91/7206	2.87677578404e-10
ko04261	Adrenergic signaling in cardiomyocytes	57/859	205/7206	3.998704876e-10
ko04921	Oxytocin signaling pathway	57/859	209/7206	7.36299759152e-10
ko04020	Calcium signaling pathway	67/859	265/7206	8.35964088607e-10
ko04970	Salivary secretion	34/859	95/7206	1.09228509027e-09
ko04744	Phototransduction	19/859	36/7206	2.75302252593e-09
ko05030	Cocaine addiction	28/859	73/7206	5.49270151226e-09
ko04010	MAPK signaling pathway	71/859	321/7206	1.29636075311e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	26/859	74/7206	1.55573019551e-07
ko04072	Phospholipase D signaling pathway	49/859	197/7206	2.96120403465e-07
ko03040	Spliceosome	1/859	145/7206	3.554950052e-07
ko04730	Long-term depression	26/859	78/7206	5.11418099595e-07
ko04971	Gastric acid secretion	30/859	98/7206	5.63434985557e-07
ko04972	Pancreatic secretion	32/859	111/7206	1.73997890537e-06
ko04060	Cytokine-cytokine receptor interaction	5/859	191/7206	4.29809956737e-06
ko05203	Viral carcinogenesis	11/859	277/7206	4.31036163295e-06
ko04925	Aldosterone synthesis and secretion	29/859	105/7206	1.00805965199e-05
ko04740	Olfactory transduction	24/859	80/7206	1.11711739887e-05
ko05168	Herpes simplex infection	5/859	182/7206	1.28301343945e-05
ko04514	Cell adhesion molecules (CAMs)	33/859	130/7206	2.54268673939e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/859	79/7206	2.90590126534e-05
ko04360	Axon guidance	50/859	233/7206	3.04358647247e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/859	59/7206	3.04428530043e-05
ko04540	Gap junction	32/859	128/7206	4.11928457474e-05
ko04621	NOD-like receptor signaling pathway	5/859	157/7206	0.000152326783502
ko04022	cGMP-PKG signaling pathway	45/859	216/7206	0.00015780241001
ko04915	Estrogen signaling pathway	31/859	131/7206	0.000172638574525
ko04260	Cardiac muscle contraction	25/859	98/7206	0.000199135200075
ko03013	RNA transport	6/859	166/7206	0.000237136770375
ko05164	Influenza A	6/859	167/7206	0.000239010399014
ko04120	Ubiquitin mediated proteolysis	4/859	138/7206	0.000270004944601
ko04070	Phosphatidylinositol signaling system	27/859	112/7206	0.000304277176492
ko05322	Systemic lupus erythematosus	5/859	151/7206	0.000308355770152
ko04014	Ras signaling pathway	53/859	279/7206	0.00045179364573
ko04932	Non-alcoholic fatty liver disease (NAFLD)	8/859	182/7206	0.000682410865557
ko04015	Rap1 signaling pathway	52/859	278/7206	0.000871347287397
ko04612	Antigen processing and presentation	1/859	77/7206	0.00113478383903
ko04964	Proximal tubule bicarbonate reclamation	10/859	29/7206	0.00130947416196
ko05162	Measles	4/859	120/7206	0.00153755899562
ko04141	Protein processing in endoplasmic reticulum	9/859	184/7206	0.00168180649979
ko05414	Dilated cardiomyopathy	25/859	112/7206	0.00170190910128
ko04110	Cell cycle	6/859	145/7206	0.00171077039648
ko05169	Epstein-Barr virus infection	11/859	206/7206	0.00206044640756
ko04217	Necroptosis	9/859	178/7206	0.00224047870439
ko04976	Bile secretion	19/859	80/7206	0.00265569166879
ko04973	Carbohydrate digestion and absorption	12/859	42/7206	0.00280054533064
ko03018	RNA degradation	2/859	84/7206	0.00337165048028
ko04745	Phototransduction - fly	11/859	38/7206	0.00371606457752
ko04071	Sphingolipid signaling pathway	32/859	162/7206	0.00436804005387
ko03008	Ribosome biogenesis in eukaryotes	2/859	79/7206	0.0047967303053
ko04640	Hematopoietic cell lineage	1/859	64/7206	0.00555471912501
ko05231	Choline metabolism in cancer	27/859	134/7206	0.00644897516518
ko04924	Renin secretion	19/859	86/7206	0.00661995705481
ko04918	Thyroid hormone synthesis	19/859	86/7206	0.00661995705481
ko04666	Fc gamma R-mediated phagocytosis	25/859	122/7206	0.00668195140875
ko04960	Aldosterone-regulated sodium reabsorption	11/859	41/7206	0.0069904470223
ko05034	Alcoholism	42/859	238/7206	0.00794817782942
ko01200	Carbon metabolism	6/859	128/7206	0.00829052964995
ko00330	Arginine and proline metabolism	1/859	61/7206	0.00830951959664
ko04350	TGF-beta signaling pathway	4/859	103/7206	0.00837371007154
ko04966	Collecting duct acid secretion	8/859	26/7206	0.00861778088731
ko05205	Proteoglycans in cancer	19/859	271/7206	0.00958820166625
ko04214	Apoptosis - fly	2/859	72/7206	0.00995705682208
ko00310	Lysine degradation	2/859	73/7206	0.0100128387616
ko04062	Chemokine signaling pathway	36/859	201/7206	0.0108469749663
ko04750	Inflammatory mediator regulation of TRP channels	24/859	122/7206	0.0110065267194
ko04270	Vascular smooth muscle contraction	29/859	154/7206	0.0113736540696
ko00240	Pyrimidine metabolism	5/859	110/7206	0.0114228257069
ko04371	Apelin signaling pathway	32/859	177/7206	0.0135460615063
ko04064	NF-kappa B signaling pathway	4/859	96/7206	0.0160950934428
ko00280	Valine, leucine and isoleucine degradation	1/859	54/7206	0.017934997023
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/859	14/7206	0.0189326215988
ko04912	GnRH signaling pathway	23/859	122/7206	0.0233138777239
ko05145	Toxoplasmosis	7/859	126/7206	0.025400222517
ko04330	Notch signaling pathway	2/859	62/7206	0.0291971458154
ko04657	IL-17 signaling pathway	4/859	87/7206	0.0298794831818
ko05140	Leishmaniasis	3/859	75/7206	0.0303259076346
ko04146	Peroxisome	4/859	89/7206	0.0304809345421
ko04930	Type II diabetes mellitus	12/859	54/7206	0.0314092604087
ko05214	Glioma	16/859	79/7206	0.0336579663481
ko00071	Fatty acid degradation	1/859	45/7206	0.0375753333724
ko03420	Nucleotide excision repair	1/859	46/7206	0.0377464743629
ko05410	Hypertrophic cardiomyopathy (HCM)	19/859	100/7206	0.0412108052455
ko00562	Inositol phosphate metabolism	17/859	89/7206	0.046325497423
ko04978	Mineral absorption	9/859	40/7206	0.0484229952411