ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 36/597 134/7206 1.0043680258e-10 ko04060 Cytokine-cytokine receptor interaction 39/597 191/7206 1.33653923637e-07 ko04610 Complement and coagulation cascades 22/597 79/7206 2.34495982964e-07 ko04621 NOD-like receptor signaling pathway 32/597 157/7206 1.25381632066e-06 ko04668 TNF signaling pathway 25/597 120/7206 1.22995041492e-05 ko03013 RNA transport 1/597 166/7206 1.2450313755e-05 ko00120 Primary bile acid biosynthesis 9/597 20/7206 1.2649251872e-05 ko05034 Alcoholism 4/597 238/7206 1.98775550063e-05 ko04974 Protein digestion and absorption 21/597 96/7206 2.81741890807e-05 ko00643 Styrene degradation 4/597 4/7206 4.66776130784e-05 ko03040 Spliceosome 1/597 145/7206 9.21505133933e-05 ko05164 Influenza A 29/597 167/7206 0.000154141278781 ko00350 Tyrosine metabolism 10/597 33/7206 0.000226287684725 ko03010 Ribosome 1/597 129/7206 0.00029037804773 ko04723 Retrograde endocannabinoid signaling 3/597 175/7206 0.000404384188271 ko03320 PPAR signaling pathway 15/597 69/7206 0.000416165465264 ko05150 Staphylococcus aureus infection 10/597 36/7206 0.000494994324939 ko05321 Inflammatory bowel disease (IBD) 13/597 56/7206 0.00051188689278 ko04620 Toll-like receptor signaling pathway 19/597 100/7206 0.000635352615515 ko05144 Malaria 11/597 45/7206 0.000860897880965 ko00071 Fatty acid degradation 11/597 45/7206 0.000860897880965 ko00590 Arachidonic acid metabolism 12/597 52/7206 0.000882935441539 ko04064 NF-kappa B signaling pathway 18/597 96/7206 0.00100968751817 ko05140 Leishmaniasis 15/597 75/7206 0.00105110752395 ko00140 Steroid hormone biosynthesis 10/597 41/7206 0.00149619876365 ko00360 Phenylalanine metabolism 6/597 17/7206 0.00176382661067 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/597 4/7206 0.00212406714061 ko05162 Measles 20/597 120/7206 0.00221349271101 ko04933 AGE-RAGE signaling pathway in diabetic complications 22/597 135/7206 0.00221628691466 ko04611 Platelet activation 25/597 163/7206 0.00226887427357 ko04658 Th1 and Th2 cell differentiation 17/597 96/7206 0.00229860208426 ko04662 B cell receptor signaling pathway 16/597 88/7206 0.00255945198808 ko04672 Intestinal immune network for IgA production 9/597 37/7206 0.00260918901771 ko05323 Rheumatoid arthritis 16/597 89/7206 0.00278766177161 ko05161 Hepatitis B 26/597 173/7206 0.0029197218659 ko04110 Cell cycle 3/597 145/7206 0.003297214666 ko00592 alpha-Linolenic acid metabolism 6/597 19/7206 0.00335107750249 ko04630 Jak-STAT signaling pathway 21/597 132/7206 0.00348351921376 ko04659 Th17 cell differentiation 18/597 106/7206 0.003553011758 ko04512 ECM-receptor interaction 14/597 79/7206 0.00596641068218 ko04391 Hippo signaling pathway - fly 1/597 90/7206 0.0063108687622 ko00983 Drug metabolism - other enzymes 9/597 42/7206 0.00644758238353 ko00830 Retinol metabolism 9/597 42/7206 0.00644758238353 ko00920 Sulfur metabolism 4/597 10/7206 0.00653273258171 ko04390 Hippo signaling pathway 6/597 188/7206 0.00689955686316 ko04660 T cell receptor signaling pathway 19/597 124/7206 0.00778309747482 ko04650 Natural killer cell mediated cytotoxicity 16/597 97/7206 0.00782204853665 ko05145 Toxoplasmosis 19/597 126/7206 0.00875258861168 ko00362 Benzoate degradation 3/597 6/7206 0.00935520834908 ko04728 Dopaminergic synapse 6/597 185/7206 0.00948004766893 ko05160 Hepatitis C 22/597 153/7206 0.0106814977205 ko02010 ABC transporters 8/597 39/7206 0.0130476454863 ko04740 Olfactory transduction 1/597 80/7206 0.0134366329558 ko01200 Carbon metabolism 19/597 128/7206 0.0136512325566 ko00330 Arginine and proline metabolism 11/597 61/7206 0.015574880833 ko05133 Pertussis 14/597 87/7206 0.0162376150282 ko04622 RIG-I-like receptor signaling pathway 11/597 62/7206 0.0165084339764 ko04022 cGMP-PKG signaling pathway 28/597 216/7206 0.0165322735552 ko00040 Pentose and glucuronate interconversions 6/597 26/7206 0.0173027221242 ko04623 Cytosolic DNA-sensing pathway 8/597 41/7206 0.0175159399589 ko04114 Oocyte meiosis 4/597 139/7206 0.0182382397258 ko04141 Protein processing in endoplasmic reticulum 7/597 184/7206 0.0209652511874 ko04360 Axon guidance 10/597 233/7206 0.0213216507116 ko00020 Citrate cycle (TCA cycle) 7/597 35/7206 0.0225260085446 ko00500 Starch and sucrose metabolism 7/597 35/7206 0.0225260085446 ko05322 Systemic lupus erythematosus 5/597 151/7206 0.0238131473004 ko04724 Glutamatergic synapse 5/597 152/7206 0.0241065229091 ko05146 Amoebiasis 15/597 99/7206 0.0247929134503 ko04270 Vascular smooth muscle contraction 21/597 154/7206 0.0249515707187 ko00100 Steroid biosynthesis 5/597 21/7206 0.0256033376656 ko04310 Wnt signaling pathway 7/597 181/7206 0.0278154862831 ko00982 Drug metabolism - cytochrome P450 7/597 37/7206 0.0298980103734 ko04550 Signaling pathways regulating pluripotency of stem cells 6/597 165/7206 0.030470842263 ko00053 Ascorbate and aldarate metabolism 5/597 22/7206 0.0309449022225 ko05340 Primary immunodeficiency 6/597 30/7206 0.0337030592214 ko05142 Chagas disease (American trypanosomiasis) 18/597 130/7206 0.03451455588 ko00561 Glycerolipid metabolism 10/597 63/7206 0.0372423086019 ko04976 Bile secretion 12/597 80/7206 0.0388223722664 ko05168 Herpes simplex infection 23/597 182/7206 0.0397836217136 ko05132 Salmonella infection 14/597 98/7206 0.0401859655692 ko04640 Hematopoietic cell lineage 10/597 64/7206 0.0402291586324 ko04930 Type II diabetes mellitus 9/597 54/7206 0.0409860595184 ko04120 Ubiquitin mediated proteolysis 5/597 138/7206 0.0421009734689 ko05217 Basal cell carcinoma 1/597 68/7206 0.0425161428171 ko04137 Mitophagy - animal 12/597 82/7206 0.0433949023186 ko00950 Isoquinoline alkaloid biosynthesis 3/597 10/7206 0.0437084487748 ko00980 Metabolism of xenobiotics by cytochrome P450 7/597 40/7206 0.0437432345523 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/597 191/7206 0.0442974616496 ko04068 FoxO signaling pathway 21/597 167/7206 0.0467629504272 ko05418 Fluid shear stress and atherosclerosis 22/597 173/7206 0.0487096025824