ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1301	423/7206	5.67905262755e-47
ko04724	Glutamatergic synapse	91/1301	152/7206	3.80919521332e-31
ko05033	Nicotine addiction	47/1301	56/7206	8.00419003654e-27
ko05032	Morphine addiction	70/1301	110/7206	1.78561446624e-26
ko04727	GABAergic synapse	69/1301	110/7206	1.45917864195e-25
ko04713	Circadian entrainment	75/1301	136/7206	9.74419723025e-23
ko04721	Synaptic vesicle cycle	51/1301	80/7206	1.2021479792e-19
ko04725	Cholinergic synapse	78/1301	160/7206	2.98482824778e-19
ko04728	Dopaminergic synapse	85/1301	185/7206	8.46898016067e-19
ko04723	Retrograde endocannabinoid signaling	80/1301	175/7206	1.35960952164e-17
ko04024	cAMP signaling pathway	109/1301	279/7206	3.16479435362e-17
ko04020	Calcium signaling pathway	103/1301	265/7206	3.85159814357e-16
ko04911	Insulin secretion	58/1301	117/7206	4.93174612968e-15
ko04726	Serotonergic synapse	62/1301	137/7206	1.18585361805e-13
ko04742	Taste transduction	37/1301	61/7206	1.32051974017e-13
ko04744	Phototransduction	26/1301	36/7206	1.48906447213e-12
ko04921	Oxytocin signaling pathway	80/1301	209/7206	3.08257344568e-12
ko03010	Ribosome	1/1301	129/7206	3.4789266646e-10
ko05031	Amphetamine addiction	42/1301	91/7206	5.35990494378e-10
ko04970	Salivary secretion	43/1301	95/7206	7.1721239596e-10
ko04261	Adrenergic signaling in cardiomyocytes	73/1301	205/7206	1.55314096617e-09
ko03040	Spliceosome	3/1301	145/7206	2.36705485352e-09
ko04720	Long-term potentiation	43/1301	99/7206	5.82767143351e-09
ko05168	Herpes simplex infection	8/1301	182/7206	4.31180701191e-08
ko04022	cGMP-PKG signaling pathway	70/1301	216/7206	2.15493513877e-07
ko05322	Systemic lupus erythematosus	6/1301	151/7206	2.77688546607e-07
ko04740	Olfactory transduction	34/1301	80/7206	3.96627626521e-07
ko04925	Aldosterone synthesis and secretion	41/1301	105/7206	5.0265219698e-07
ko03013	RNA transport	8/1301	166/7206	5.90169594598e-07
ko05203	Viral carcinogenesis	21/1301	277/7206	6.02032301672e-07
ko04966	Collecting duct acid secretion	16/1301	26/7206	1.00035597267e-06
ko04971	Gastric acid secretion	38/1301	98/7206	1.04108335772e-06
ko04621	NOD-like receptor signaling pathway	8/1301	157/7206	2.57794812617e-06
ko05030	Cocaine addiction	30/1301	73/7206	3.77512991099e-06
ko04060	Cytokine-cytokine receptor interaction	13/1301	191/7206	9.06009662353e-06
ko04976	Bile secretion	31/1301	80/7206	1.18549764473e-05
ko04110	Cell cycle	8/1301	145/7206	1.52307331596e-05
ko05164	Influenza A	11/1301	167/7206	2.39390673408e-05
ko04964	Proximal tubule bicarbonate reclamation	15/1301	29/7206	3.97733169178e-05
ko04514	Cell adhesion molecules (CAMs)	43/1301	130/7206	4.15830716964e-05
ko04360	Axon guidance	67/1301	233/7206	4.23675550916e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1301	79/7206	4.4662831211e-05
ko04972	Pancreatic secretion	38/1301	111/7206	4.85259717673e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1301	74/7206	4.99616685424e-05
ko04070	Phosphatidylinositol signaling system	38/1301	112/7206	5.33374865963e-05
ko04141	Protein processing in endoplasmic reticulum	14/1301	184/7206	6.00595785041e-05
ko04730	Long-term depression	29/1301	78/7206	7.42522353373e-05
ko05140	Leishmaniasis	2/1301	75/7206	0.000104434160857
ko04540	Gap junction	41/1301	128/7206	0.000107784903261
ko04120	Ubiquitin mediated proteolysis	9/1301	138/7206	0.000121895549485
ko04745	Phototransduction - fly	17/1301	38/7206	0.000128693237252
ko04072	Phospholipase D signaling pathway	57/1301	197/7206	0.000150911976897
ko05161	Hepatitis B	14/1301	173/7206	0.000277605605639
ko04610	Complement and coagulation cascades	3/1301	79/7206	0.000305818179815
ko00520	Amino sugar and nucleotide sugar metabolism	1/1301	55/7206	0.000330190004534
ko04064	NF-kappa B signaling pathway	5/1301	96/7206	0.000409629777683
ko05110	Vibrio cholerae infection	23/1301	63/7206	0.000429872431325
ko05169	Epstein-Barr virus infection	19/1301	206/7206	0.000444284400737
ko04924	Renin secretion	29/1301	86/7206	0.000555742077103
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1301	79/7206	0.000562660214019
ko05414	Dilated cardiomyopathy	35/1301	112/7206	0.000700069400378
ko04371	Apelin signaling pathway	50/1301	177/7206	0.000708861497593
ko04750	Inflammatory mediator regulation of TRP channels	37/1301	122/7206	0.00080463748719
ko04923	Regulation of lipolysis in adipocytes	26/1301	77/7206	0.000856866695417
ko04710	Circadian rhythm	17/1301	43/7206	0.0009453642223
ko04010	MAPK signaling pathway	81/1301	321/7206	0.00104238247871
ko04014	Ras signaling pathway	72/1301	279/7206	0.00107411364512
ko04612	Antigen processing and presentation	4/1301	77/7206	0.0015267223561
ko05205	Proteoglycans in cancer	30/1301	271/7206	0.00164124059645
ko03420	Nucleotide excision repair	1/1301	46/7206	0.00176257733146
ko04260	Cardiac muscle contraction	30/1301	98/7206	0.00216097048915
ko03022	Basal transcription factors	1/1301	44/7206	0.00267128592326
ko05166	HTLV-I infection	34/1301	292/7206	0.00306149657744
ko04210	Apoptosis	18/1301	180/7206	0.00314246913177
ko05162	Measles	10/1301	120/7206	0.00380180366296
ko04915	Estrogen signaling pathway	37/1301	131/7206	0.00387519535096
ko04217	Necroptosis	18/1301	178/7206	0.00405844824824
ko04622	RIG-I-like receptor signaling pathway	3/1301	62/7206	0.00417862334549
ko04657	IL-17 signaling pathway	6/1301	87/7206	0.00459380683994
ko05133	Pertussis	6/1301	87/7206	0.00459380683994
ko05145	Toxoplasmosis	11/1301	126/7206	0.00472822900946
ko04922	Glucagon signaling pathway	36/1301	128/7206	0.00501850262687
ko00240	Pyrimidine metabolism	9/1301	110/7206	0.00554463337936
ko04630	Jak-STAT signaling pathway	12/1301	132/7206	0.00576864982013
ko04930	Type II diabetes mellitus	18/1301	54/7206	0.00671554420358
ko05219	Bladder cancer	2/1301	48/7206	0.00769026432752
ko04270	Vascular smooth muscle contraction	41/1301	154/7206	0.00777770524515
ko05321	Inflammatory bowel disease (IBD)	3/1301	56/7206	0.00857659337492
ko04626	Plant-pathogen interaction	8/1301	18/7206	0.00870208002975
ko05131	Shigellosis	6/1301	82/7206	0.00874636683946
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1301	59/7206	0.00950536568651
ko04658	Th1 and Th2 cell differentiation	8/1301	96/7206	0.0106214867868
ko04330	Notch signaling pathway	4/1301	62/7206	0.0125959953686
ko04214	Apoptosis - fly	5/1301	72/7206	0.0126839689954
ko05200	Pathways in cancer	69/1301	492/7206	0.0151164000153
ko05206	MicroRNAs in cancer	20/1301	177/7206	0.017221917333
ko00562	Inositol phosphate metabolism	25/1301	89/7206	0.0178618063246
ko04510	Focal adhesion	30/1301	240/7206	0.0211588311013
ko04115	p53 signaling pathway	6/1301	74/7206	0.0222869758643
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1301	100/7206	0.0252889408696
ko04146	Peroxisome	8/1301	89/7206	0.0255431609789
ko05222	Small cell lung cancer	8/1301	89/7206	0.0255431609789
ko04810	Regulation of actin cytoskeleton	34/1301	264/7206	0.0273802800195
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1301	14/7206	0.0275382989464
ko04142	Lysosome	17/1301	151/7206	0.0317214910372
ko04932	Non-alcoholic fatty liver disease (NAFLD)	22/1301	182/7206	0.0318812614621
ko03410	Base excision repair	2/1301	38/7206	0.0349136212619
ko04620	Toll-like receptor signaling pathway	10/1301	100/7206	0.0355228461669
ko04960	Aldosterone-regulated sodium reabsorption	13/1301	41/7206	0.0383343344806
ko04113	Meiosis - yeast	6/1301	70/7206	0.0410307545549
ko04973	Carbohydrate digestion and absorption	13/1301	42/7206	0.0415688848814
ko03018	RNA degradation	8/1301	84/7206	0.0446061923914
ko05215	Prostate cancer	12/1301	111/7206	0.0462949049994
ko04918	Thyroid hormone synthesis	23/1301	86/7206	0.0468554473847
ko05320	Autoimmune thyroid disease	1/1301	29/7206	0.0485698803318
ko00010	Glycolysis / Gluconeogenesis	20/1301	74/7206	0.0485964667609
ko01524	Platinum drug resistance	7/1301	76/7206	0.0498272842298