ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 39/256 191/7206 1.08286613273e-19 ko04380 Osteoclast differentiation 32/256 134/7206 1.97805247865e-18 ko04621 NOD-like receptor signaling pathway 33/256 157/7206 3.5921733102e-17 ko05321 Inflammatory bowel disease (IBD) 20/256 56/7206 1.22862400242e-15 ko05164 Influenza A 32/256 167/7206 1.90922390051e-15 ko05168 Herpes simplex infection 33/256 182/7206 3.68420182361e-15 ko05340 Primary immunodeficiency 15/256 30/7206 1.1631153737e-14 ko04217 Necroptosis 32/256 178/7206 1.28624159768e-14 ko04064 NF-kappa B signaling pathway 23/256 96/7206 1.46256220278e-13 ko05162 Measles 25/256 120/7206 3.75795504722e-13 ko05140 Leishmaniasis 20/256 75/7206 6.85732369611e-13 ko05145 Toxoplasmosis 25/256 126/7206 1.20767967176e-12 ko05152 Tuberculosis 30/256 187/7206 2.0471323504e-12 ko04659 Th17 cell differentiation 22/256 106/7206 1.12921222742e-11 ko04620 Toll-like receptor signaling pathway 21/256 100/7206 2.67381167675e-11 ko04612 Antigen processing and presentation 18/256 77/7206 1.12052498473e-10 ko04650 Natural killer cell mediated cytotoxicity 20/256 97/7206 1.15290983615e-10 ko05330 Allograft rejection 11/256 24/7206 1.52424500236e-10 ko04630 Jak-STAT signaling pathway 23/256 132/7206 1.62610216827e-10 ko04658 Th1 and Th2 cell differentiation 19/256 96/7206 7.18629465884e-10 ko05161 Hepatitis B 25/256 173/7206 1.56020458728e-09 ko05320 Autoimmune thyroid disease 11/256 29/7206 1.80333855948e-09 ko05167 Kaposi's sarcoma-associated herpesvirus infection 26/256 191/7206 2.6860241959e-09 ko05332 Graft-versus-host disease 9/256 18/7206 2.88139502841e-09 ko04660 T cell receptor signaling pathway 19/256 124/7206 5.99149669221e-08 ko05160 Hepatitis C 21/256 153/7206 8.47855395518e-08 ko04940 Type I diabetes mellitus 10/256 32/7206 8.69652482082e-08 ko04622 RIG-I-like receptor signaling pathway 13/256 62/7206 1.85918021238e-07 ko04672 Intestinal immune network for IgA production 10/256 37/7206 4.01236662017e-07 ko05310 Asthma 7/256 17/7206 9.43613643673e-07 ko04668 TNF signaling pathway 17/256 120/7206 9.59046035096e-07 ko04640 Hematopoietic cell lineage 12/256 64/7206 1.97881173679e-06 ko04062 Chemokine signaling pathway 21/256 201/7206 8.04311082696e-06 ko04623 Cytosolic DNA-sensing pathway 9/256 41/7206 1.01217039734e-05 ko05133 Pertussis 13/256 87/7206 1.03527218128e-05 ko05142 Chagas disease (American trypanosomiasis) 16/256 130/7206 1.29528608249e-05 ko05323 Rheumatoid arthritis 13/256 89/7206 1.33508141291e-05 ko04145 Phagosome 18/256 162/7206 1.56936986581e-05 ko05144 Malaria 9/256 45/7206 2.26041361736e-05 ko05150 Staphylococcus aureus infection 8/256 36/7206 2.89882819908e-05 ko05169 Epstein-Barr virus infection 20/256 206/7206 3.9061149356e-05 ko05166 HTLV-I infection 25/256 292/7206 5.70730998511e-05 ko04662 B cell receptor signaling pathway 12/256 88/7206 5.79418526302e-05 ko04210 Apoptosis 18/256 180/7206 6.51302057201e-05 ko04664 Fc epsilon RI signaling pathway 10/256 77/7206 0.000361187990786 ko03050 Proteasome 8/256 54/7206 0.000573125504838 ko05416 Viral myocarditis 8/256 55/7206 0.00065044581409 ko05134 Legionellosis 9/256 74/7206 0.00114781571569 ko04514 Cell adhesion molecules (CAMs) 12/256 130/7206 0.00216996404789 ko04670 Leukocyte transendothelial migration 13/256 151/7206 0.00268385429321 ko05146 Amoebiasis 9/256 99/7206 0.0083432795393 ko05418 Fluid shear stress and atherosclerosis 13/256 173/7206 0.0102279772513 ko04666 Fc gamma R-mediated phagocytosis 10/256 122/7206 0.0112647417262 ko04657 IL-17 signaling pathway 8/256 87/7206 0.0117951699742 ko04728 Dopaminergic synapse 1/256 185/7206 0.0150954454418 ko04611 Platelet activation 12/256 163/7206 0.0156085462691 ko05034 Alcoholism 2/256 238/7206 0.0184667144393 ko04610 Complement and coagulation cascades 7/256 79/7206 0.0216740551428 ko04310 Wnt signaling pathway 1/256 181/7206 0.0224368809644 ko05132 Salmonella infection 8/256 98/7206 0.0228123745497 ko05143 African trypanosomiasis 4/256 32/7206 0.0256068493877 ko05212 Pancreatic cancer 7/256 83/7206 0.0275781373225 ko04933 AGE-RAGE signaling pathway in diabetic complications 10/256 135/7206 0.0288319071739 ko05203 Viral carcinogenesis 17/256 277/7206 0.0290032467737 ko04917 Prolactin signaling pathway 7/256 87/7206 0.0344910059185 ko05016 Huntington's disease 2/256 215/7206 0.0363818589468 ko00590 Arachidonic acid metabolism 5/256 52/7206 0.0363888503269 ko05222 Small cell lung cancer 7/256 89/7206 0.0383439761535 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/256 92/7206 0.0446362153713 ko04724 Glutamatergic synapse 1/256 152/7206 0.0451209641559 ko04270 Vascular smooth muscle contraction 1/256 154/7206 0.0452942972383 ko00230 Purine metabolism 2/256 194/7206 0.0490313502692