ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 43/386 191/7206 2.05999694485e-16 ko05164 Influenza A 35/386 167/7206 1.44161729108e-12 ko04380 Osteoclast differentiation 31/386 134/7206 1.85595095254e-12 ko05340 Primary immunodeficiency 15/386 30/7206 4.8747580692e-12 ko05162 Measles 28/386 120/7206 1.83842173815e-11 ko04621 NOD-like receptor signaling pathway 32/386 157/7206 3.01431859697e-11 ko05321 Inflammatory bowel disease (IBD) 18/386 56/7206 2.8926987163e-10 ko04650 Natural killer cell mediated cytotoxicity 23/386 97/7206 8.77126095276e-10 ko04659 Th17 cell differentiation 24/386 106/7206 1.03093068625e-09 ko05140 Leishmaniasis 20/386 75/7206 1.22678216732e-09 ko04620 Toll-like receptor signaling pathway 23/386 100/7206 1.67007163813e-09 ko05168 Herpes simplex infection 31/386 182/7206 6.5456039207e-09 ko05145 Toxoplasmosis 25/386 126/7206 8.4555812424e-09 ko05152 Tuberculosis 31/386 187/7206 1.27758231554e-08 ko04217 Necroptosis 30/386 178/7206 1.49476321002e-08 ko05150 Staphylococcus aureus infection 13/386 36/7206 1.83314972237e-08 ko04064 NF-kappa B signaling pathway 21/386 96/7206 2.25086029396e-08 ko04672 Intestinal immune network for IgA production 13/386 37/7206 2.69049146399e-08 ko04610 Complement and coagulation cascades 18/386 79/7206 1.19731886574e-07 ko05320 Autoimmune thyroid disease 11/386 29/7206 1.30564121585e-07 ko04630 Jak-STAT signaling pathway 23/386 132/7206 4.09427168954e-07 ko04612 Antigen processing and presentation 17/386 77/7206 4.38241843141e-07 ko04660 T cell receptor signaling pathway 22/386 124/7206 5.31977263516e-07 ko04658 Th1 and Th2 cell differentiation 19/386 96/7206 5.63701810889e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 28/386 191/7206 9.23943053368e-07 ko05330 Allograft rejection 9/386 24/7206 2.10928253771e-06 ko05323 Rheumatoid arthritis 16/386 89/7206 1.62067833282e-05 ko05332 Graft-versus-host disease 7/386 18/7206 2.2802471973e-05 ko04640 Hematopoietic cell lineage 13/386 64/7206 2.63948874018e-05 ko04062 Chemokine signaling pathway 26/386 201/7206 3.64411060317e-05 ko05161 Hepatitis B 23/386 173/7206 4.44760171374e-05 ko05034 Alcoholism 1/386 238/7206 4.90666634457e-05 ko05133 Pertussis 15/386 87/7206 4.96396430155e-05 ko05142 Chagas disease (American trypanosomiasis) 19/386 130/7206 5.61095795221e-05 ko04622 RIG-I-like receptor signaling pathway 12/386 62/7206 8.86830005864e-05 ko05144 Malaria 10/386 45/7206 0.00010206148859 ko05310 Asthma 6/386 17/7206 0.000169724143454 ko05160 Hepatitis C 20/386 153/7206 0.000176303130178 ko04623 Cytosolic DNA-sensing pathway 9/386 41/7206 0.000250725472628 ko04145 Phagosome 20/386 162/7206 0.000502577892878 ko04514 Cell adhesion molecules (CAMs) 17/386 130/7206 0.000531714493917 ko04728 Dopaminergic synapse 1/386 185/7206 0.000724745251166 ko04662 B cell receptor signaling pathway 13/386 88/7206 0.000748835337691 ko04723 Retrograde endocannabinoid signaling 1/386 175/7206 0.00105245104907 ko04310 Wnt signaling pathway 1/386 181/7206 0.00111441891745 ko04940 Type I diabetes mellitus 7/386 32/7206 0.00125663812266 ko04137 Mitophagy - animal 12/386 82/7206 0.00129061065084 ko00590 Arachidonic acid metabolism 9/386 52/7206 0.00156210589802 ko04668 TNF signaling pathway 15/386 120/7206 0.00177202065464 ko04210 Apoptosis 19/386 180/7206 0.00393425793168 ko04068 FoxO signaling pathway 18/386 167/7206 0.00444842045564 ko03040 Spliceosome 1/386 145/7206 0.0047794064117 ko05132 Salmonella infection 12/386 98/7206 0.00585871356613 ko04666 Fc gamma R-mediated phagocytosis 14/386 122/7206 0.0066075735208 ko04611 Platelet activation 17/386 163/7206 0.00739883854836 ko03050 Proteasome 8/386 54/7206 0.00751445250923 ko04664 Fc epsilon RI signaling pathway 10/386 77/7206 0.00762574850654 ko05416 Viral myocarditis 8/386 55/7206 0.00839473307626 ko04670 Leukocyte transendothelial migration 16/386 151/7206 0.00891063273325 ko05224 Breast cancer 2/386 174/7206 0.00915682561839 ko04713 Circadian entrainment 1/386 136/7206 0.0105517597384 ko05169 Epstein-Barr virus infection 20/386 206/7206 0.0106699715643 ko05131 Shigellosis 10/386 82/7206 0.0117434439667 ko04390 Hippo signaling pathway 3/386 188/7206 0.0134315379956 ko04933 AGE-RAGE signaling pathway in diabetic complications 14/386 135/7206 0.0178497306294 ko00980 Metabolism of xenobiotics by cytochrome P450 6/386 40/7206 0.0185820682853 ko00120 Primary bile acid biosynthesis 4/386 20/7206 0.0198319185293 ko04911 Insulin secretion 1/386 117/7206 0.0211908510417 ko04530 Tight junction 5/386 228/7206 0.0248546164152 ko04360 Axon guidance 5/386 233/7206 0.0251343080243 ko04657 IL-17 signaling pathway 10/386 87/7206 0.025427416378 ko05010 Alzheimer's disease 4/386 202/7206 0.0256693328892 ko05032 Morphine addiction 1/386 110/7206 0.0306628234269 ko04726 Serotonergic synapse 2/386 137/7206 0.0343039053063 ko04114 Oocyte meiosis 2/386 139/7206 0.0344988329523 ko05418 Fluid shear stress and atherosclerosis 16/386 173/7206 0.0373535753118 ko05204 Chemical carcinogenesis 6/386 48/7206 0.0416388536327 ko04142 Lysosome 14/386 151/7206 0.0418895971553 ko05016 Huntington's disease 5/386 215/7206 0.0443680451168 ko00982 Drug metabolism - cytochrome P450 5/386 37/7206 0.0456817478835 ko00511 Other glycan degradation 4/386 26/7206 0.0476190463357 ko04915 Estrogen signaling pathway 2/386 131/7206 0.0481799573131