ko pathway ratio_in_study ratio_in_pop p_value ko05217 Basal cell carcinoma 26/581 68/7206 3.72728278575e-12 ko03040 Spliceosome 37/581 145/7206 1.26448700438e-10 ko04110 Cell cycle 37/581 145/7206 1.26448700438e-10 ko03030 DNA replication 17/581 38/7206 1.18498783844e-09 ko04390 Hippo signaling pathway 41/581 188/7206 2.22733476897e-09 ko04550 Signaling pathways regulating pluripotency of stem cells 37/581 165/7206 6.23243810188e-09 ko04111 Cell cycle - yeast 25/581 90/7206 2.15712505902e-08 ko04080 Neuroactive ligand-receptor interaction 9/581 423/7206 1.63854259444e-07 ko04113 Meiosis - yeast 19/581 70/7206 1.59054252555e-06 ko04340 Hedgehog signaling pathway 17/581 58/7206 1.75717020016e-06 ko04310 Wnt signaling pathway 34/581 181/7206 2.42132136037e-06 ko04950 Maturity onset diabetes of the young 11/581 29/7206 7.67882626945e-06 ko05010 Alzheimer's disease 2/581 202/7206 1.00856428061e-05 ko03015 mRNA surveillance pathway 21/581 93/7206 1.11245913745e-05 ko04330 Notch signaling pathway 16/581 62/7206 2.13206932126e-05 ko04391 Hippo signaling pathway - fly 20/581 90/7206 2.30850376105e-05 ko05224 Breast cancer 31/581 174/7206 2.51434187596e-05 ko04144 Endocytosis 9/581 342/7206 3.70238086176e-05 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/581 182/7206 4.6362772506e-05 ko04724 Glutamatergic synapse 1/581 152/7206 6.14185439983e-05 ko04020 Calcium signaling pathway 6/581 265/7206 7.79275482263e-05 ko04072 Phospholipase D signaling pathway 3/581 197/7206 9.36326104063e-05 ko04723 Retrograde endocannabinoid signaling 2/581 175/7206 0.000102394359206 ko04360 Axon guidance 36/581 233/7206 0.000121124202905 ko03410 Base excision repair 11/581 38/7206 0.000136535534314 ko04726 Serotonergic synapse 1/581 137/7206 0.000198677409476 ko04725 Cholinergic synapse 2/581 160/7206 0.000314207045215 ko05202 Transcriptional misregulation in cancer 30/581 188/7206 0.000315348729416 ko04062 Chemokine signaling pathway 4/581 201/7206 0.000333682426586 ko04371 Apelin signaling pathway 3/581 177/7206 0.000395958737095 ko05012 Parkinson's disease 2/581 155/7206 0.00045532172621 ko04066 HIF-1 signaling pathway 1/581 123/7206 0.00064132391841 ko04060 Cytokine-cytokine receptor interaction 4/581 191/7206 0.000663982562065 ko03430 Mismatch repair 7/581 22/7206 0.00124593470905 ko04727 GABAergic synapse 1/581 110/7206 0.00210663397455 ko04921 Oxytocin signaling pathway 6/581 209/7206 0.00277513260888 ko05205 Proteoglycans in cancer 36/581 271/7206 0.00283388769536 ko05166 HTLV-I infection 38/581 292/7206 0.00285808205683 ko03420 Nucleotide excision repair 10/581 46/7206 0.00306536821109 ko04141 Protein processing in endoplasmic reticulum 5/581 184/7206 0.00372436722909 ko04912 GnRH signaling pathway 2/581 122/7206 0.00392772112396 ko04211 Longevity regulating pathway 2/581 123/7206 0.003950473087 ko04650 Natural killer cell mediated cytotoxicity 1/581 97/7206 0.00434691010445 ko04971 Gastric acid secretion 1/581 98/7206 0.00436662749456 ko05200 Pathways in cancer 57/581 492/7206 0.00449590825003 ko04713 Circadian entrainment 3/581 136/7206 0.0064147075643 ko05211 Renal cell carcinoma 1/581 96/7206 0.00676940535839 ko04621 NOD-like receptor signaling pathway 4/581 157/7206 0.00693036190246 ko04972 Pancreatic secretion 2/581 111/7206 0.0080183828697 ko04915 Estrogen signaling pathway 3/581 131/7206 0.00898670385316 ko05231 Choline metabolism in cancer 3/581 134/7206 0.00926420954896 ko05130 Pathogenic Escherichia coli infection 13/581 77/7206 0.00950421461672 ko04612 Antigen processing and presentation 13/581 77/7206 0.00950421461672 ko00190 Oxidative phosphorylation 3/581 127/7206 0.0126271969616 ko01200 Carbon metabolism 3/581 128/7206 0.0127626139753 ko04922 Glucagon signaling pathway 3/581 128/7206 0.0127626139753 ko04013 MAPK signaling pathway - fly 17/581 115/7206 0.0140113344468 ko04712 Circadian rhythm - plant 3/581 7/7206 0.0142666589574 ko04022 cGMP-PKG signaling pathway 8/581 216/7206 0.0151054228502 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 6/581 26/7206 0.0152821250241 ko04925 Aldosterone synthesis and secretion 2/581 105/7206 0.0168659265743 ko05169 Epstein-Barr virus infection 26/581 206/7206 0.0191559281003 ko04610 Complement and coagulation cascades 1/581 79/7206 0.0200008472501 ko04976 Bile secretion 1/581 80/7206 0.0203663420577 ko04740 Olfactory transduction 1/581 80/7206 0.0203663420577 ko04138 Autophagy - yeast 1/581 81/7206 0.0208713226123 ko04910 Insulin signaling pathway 6/581 172/7206 0.0225078635709 ko04620 Toll-like receptor signaling pathway 2/581 100/7206 0.0239013154139 ko04911 Insulin secretion 3/581 117/7206 0.0244443861464 ko04114 Oocyte meiosis 19/581 139/7206 0.0256493344935 ko05134 Legionellosis 1/581 74/7206 0.0290507357161 ko00514 Other types of O-glycan biosynthesis 6/581 30/7206 0.0299908315809 ko04341 Hedgehog signaling pathway - fly 7/581 38/7206 0.0299928883841 ko05222 Small cell lung cancer 13/581 89/7206 0.0301270240138 ko04014 Ras signaling pathway 13/581 279/7206 0.0324899184123 ko03010 Ribosome 4/581 129/7206 0.0330138706646 ko04970 Salivary secretion 2/581 95/7206 0.0337668340304 ko04070 Phosphatidylinositol signaling system 3/581 112/7206 0.0338331931634 ko05206 MicroRNAs in cancer 22/581 177/7206 0.0358881424468 ko03050 Proteasome 9/581 54/7206 0.0377512253887 ko04611 Platelet activation 6/581 163/7206 0.0399727863297 ko04350 TGF-beta signaling pathway 14/581 103/7206 0.0446058395916 ko05145 Toxoplasmosis 4/581 126/7206 0.0453666553464 ko04213 Longevity regulating pathway - multiple species 2/581 86/7206 0.0454962034518 ko05133 Pertussis 2/581 87/7206 0.045680495874 ko04662 B cell receptor signaling pathway 2/581 88/7206 0.0460833478984 ko04920 Adipocytokine signaling pathway 2/581 89/7206 0.0467038606899 ko00240 Pyrimidine metabolism 15/581 110/7206 0.0489036468038