ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 94/795 423/7206 7.19356118547e-12 ko04724 Glutamatergic synapse 45/795 152/7206 2.17297673827e-10 ko04713 Circadian entrainment 38/795 136/7206 3.25529614954e-08 ko04726 Serotonergic synapse 38/795 137/7206 4.03984913532e-08 ko04911 Insulin secretion 34/795 117/7206 6.04724374851e-08 ko04727 GABAergic synapse 32/795 110/7206 1.44331967774e-07 ko05032 Morphine addiction 31/795 110/7206 4.93196357548e-07 ko04728 Dopaminergic synapse 44/795 185/7206 5.54205933324e-07 ko04721 Synaptic vesicle cycle 25/795 80/7206 7.68261870769e-07 ko05033 Nicotine addiction 20/795 56/7206 9.24824317666e-07 ko03040 Spliceosome 1/795 145/7206 1.31804030429e-06 ko05031 Amphetamine addiction 26/795 91/7206 3.10320959937e-06 ko03010 Ribosome 1/795 129/7206 6.58270502907e-06 ko04070 Phosphatidylinositol signaling system 29/795 112/7206 9.25614584634e-06 ko04925 Aldosterone synthesis and secretion 27/795 105/7206 2.16962205638e-05 ko04725 Cholinergic synapse 36/795 160/7206 2.90366776019e-05 ko04970 Salivary secretion 25/795 95/7206 3.71181856872e-05 ko03013 RNA transport 4/795 166/7206 4.72092702587e-05 ko04720 Long-term potentiation 25/795 99/7206 5.79597630647e-05 ko04514 Cell adhesion molecules (CAMs) 30/795 130/7206 9.04013723794e-05 ko04921 Oxytocin signaling pathway 42/795 209/7206 0.0001102352499 ko04020 Calcium signaling pathway 50/795 265/7206 0.000124201150699 ko04745 Phototransduction - fly 13/795 38/7206 0.000126558257622 ko04971 Gastric acid secretion 24/795 98/7206 0.000126865485626 ko04964 Proximal tubule bicarbonate reclamation 11/795 29/7206 0.000145956590428 ko05322 Systemic lupus erythematosus 4/795 151/7206 0.000197809653432 ko04022 cGMP-PKG signaling pathway 42/795 216/7206 0.000228435282217 ko04966 Collecting duct acid secretion 10/795 26/7206 0.000256579508112 ko04024 cAMP signaling pathway 51/795 279/7206 0.000270786659645 ko04730 Long-term depression 20/795 78/7206 0.000324096166874 ko04710 Circadian rhythm 13/795 43/7206 0.000506445696082 ko04723 Retrograde endocannabinoid signaling 35/795 175/7206 0.000518034194403 ko05203 Viral carcinogenesis 14/795 277/7206 0.000571461603017 ko04922 Glucagon signaling pathway 27/795 128/7206 0.000853956735416 ko04960 Aldosterone-regulated sodium reabsorption 12/795 41/7206 0.00113841651912 ko05224 Breast cancer 7/795 174/7206 0.00131971447817 ko04110 Cell cycle 5/795 145/7206 0.00178208375987 ko04120 Ubiquitin mediated proteolysis 5/795 138/7206 0.00239144779763 ko05110 Vibrio cholerae infection 15/795 63/7206 0.00351640669644 ko00120 Primary bile acid biosynthesis 7/795 20/7206 0.00412560513838 ko04014 Ras signaling pathway 46/795 279/7206 0.00456952212712 ko04750 Inflammatory mediator regulation of TRP channels 24/795 122/7206 0.00494008955259 ko04141 Protein processing in endoplasmic reticulum 9/795 184/7206 0.00566391029496 ko05169 Epstein-Barr virus infection 11/795 206/7206 0.00639701872967 ko05030 Cocaine addiction 16/795 73/7206 0.00706874135507 ko00010 Glycolysis / Gluconeogenesis 16/795 74/7206 0.00764609397063 ko04261 Adrenergic signaling in cardiomyocytes 35/795 205/7206 0.00876839098931 ko05200 Pathways in cancer 37/795 492/7206 0.00893319749429 ko04626 Plant-pathogen interaction 6/795 18/7206 0.0102291106432 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/795 59/7206 0.0116308501624 ko04972 Pancreatic secretion 21/795 111/7206 0.0133532568008 ko04924 Renin secretion 17/795 86/7206 0.0144738427717 ko05130 Pathogenic Escherichia coli infection 2/795 77/7206 0.0154464312572 ko05222 Small cell lung cancer 3/795 89/7206 0.0160293566866 ko04919 Thyroid hormone signaling pathway 25/795 143/7206 0.0207093078546 ko04650 Natural killer cell mediated cytotoxicity 18/795 97/7206 0.0222841972928 ko00350 Tyrosine metabolism 8/795 33/7206 0.0239947380677 ko00562 Inositol phosphate metabolism 17/795 89/7206 0.0247011844656 ko03050 Proteasome 1/795 54/7206 0.0266706592515 ko04932 Non-alcoholic fatty liver disease (NAFLD) 11/795 182/7206 0.0301184094472 ko05217 Basal cell carcinoma 2/795 68/7206 0.0302623657693 ko04540 Gap junction 22/795 128/7206 0.0318612374101 ko05014 Amyotrophic lateral sclerosis (ALS) 14/795 74/7206 0.0385609796715 ko04520 Adherens junction 5/795 103/7206 0.0395532781738 ko00140 Steroid hormone biosynthesis 9/795 41/7206 0.0398619206041 ko00051 Fructose and mannose metabolism 9/795 42/7206 0.0438007326708 ko04711 Circadian rhythm - fly 4/795 13/7206 0.0466414290258 ko00680 Methane metabolism 8/795 34/7206 0.0470528135837 ko04270 Vascular smooth muscle contraction 25/795 154/7206 0.0496256042635