ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 20/114 191/7206 1.18703113017e-11 ko04380 Osteoclast differentiation 17/114 134/7206 2.20926476186e-11 ko04658 Th1 and Th2 cell differentiation 12/114 96/7206 2.80733463756e-08 ko04064 NF-kappa B signaling pathway 12/114 96/7206 2.80733463756e-08 ko04630 Jak-STAT signaling pathway 13/114 132/7206 1.29801395482e-07 ko05321 Inflammatory bowel disease (IBD) 9/114 56/7206 1.83699586136e-07 ko04650 Natural killer cell mediated cytotoxicity 11/114 97/7206 3.03432644068e-07 ko05166 HTLV-I infection 18/114 292/7206 6.0758472972e-07 ko04621 NOD-like receptor signaling pathway 13/114 157/7206 9.82719686909e-07 ko04662 B cell receptor signaling pathway 10/114 88/7206 1.05867019772e-06 ko05152 Tuberculosis 14/114 187/7206 1.2444933168e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 14/114 191/7206 1.60467902587e-06 ko05162 Measles 11/114 120/7206 2.61110692655e-06 ko04668 TNF signaling pathway 11/114 120/7206 2.61110692655e-06 ko04660 T cell receptor signaling pathway 11/114 124/7206 3.60809584166e-06 ko04217 Necroptosis 13/114 178/7206 4.04904190947e-06 ko04659 Th17 cell differentiation 10/114 106/7206 5.88786987837e-06 ko05168 Herpes simplex infection 11/114 182/7206 0.000132207216902 ko04620 Toll-like receptor signaling pathway 8/114 100/7206 0.000170160014805 ko04672 Intestinal immune network for IgA production 5/114 37/7206 0.000264073494254 ko04072 Phospholipase D signaling pathway 11/114 197/7206 0.000265278852096 ko05212 Pancreatic cancer 7/114 83/7206 0.000317685550115 ko05161 Hepatitis B 10/114 173/7206 0.000386986269346 ko05169 Epstein-Barr virus infection 11/114 206/7206 0.000389803081029 ko05160 Hepatitis C 9/114 153/7206 0.000672396671011 ko05145 Toxoplasmosis 8/114 126/7206 0.000817235930226 ko05142 Chagas disease (American trypanosomiasis) 8/114 130/7206 0.00100305144873 ko05164 Influenza A 9/114 167/7206 0.00125550445145 ko04933 AGE-RAGE signaling pathway in diabetic complications 8/114 135/7206 0.00128141282434 ko04010 MAPK signaling pathway 13/114 321/7206 0.00158875545639 ko05418 Fluid shear stress and atherosclerosis 9/114 173/7206 0.00160664441883 ko04611 Platelet activation 8/114 163/7206 0.00416895757936 ko00564 Glycerophospholipid metabolism 6/114 99/7206 0.00466772011675 ko05146 Amoebiasis 6/114 99/7206 0.00466772011675 ko04068 FoxO signaling pathway 8/114 167/7206 0.00482504360443 ko04151 PI3K-Akt signaling pathway 14/114 390/7206 0.00490446632031 ko05231 Choline metabolism in cancer 7/114 134/7206 0.00519305659522 ko05140 Leishmaniasis 5/114 75/7206 0.00649860873323 ko04218 Cellular senescence 8/114 177/7206 0.00681310396995 ko04664 Fc epsilon RI signaling pathway 5/114 77/7206 0.00725659850403 ko04932 Non-alcoholic fatty liver disease (NAFLD) 8/114 182/7206 0.00801450009867 ko04610 Complement and coagulation cascades 5/114 79/7206 0.00807433675255 ko04670 Leukocyte transendothelial migration 7/114 151/7206 0.00980617021194 ko05220 Chronic myeloid leukemia 5/114 85/7206 0.0109083686462 ko04657 IL-17 signaling pathway 5/114 87/7206 0.0119871394063 ko04666 Fc gamma R-mediated phagocytosis 6/114 122/7206 0.0125799721762 ko04014 Ras signaling pathway 10/114 279/7206 0.0126210274054 ko05323 Rheumatoid arthritis 5/114 89/7206 0.0131363736216 ko05222 Small cell lung cancer 5/114 89/7206 0.0131363736216 ko05200 Pathways in cancer 15/114 492/7206 0.0131443788508 ko04071 Sphingolipid signaling pathway 7/114 162/7206 0.0140676582297 ko04145 Phagosome 7/114 162/7206 0.0140676582297 ko04210 Apoptosis 7/114 180/7206 0.0236784354072 ko00565 Ether lipid metabolism 3/114 42/7206 0.0283121570195 ko05310 Asthma 2/114 17/7206 0.0289004621548 ko05202 Transcriptional misregulation in cancer 7/114 188/7206 0.0291382381938 ko05215 Prostate cancer 5/114 111/7206 0.0309267278115 ko04070 Phosphatidylinositol signaling system 5/114 112/7206 0.0319770359349 ko04370 VEGF signaling pathway 4/114 77/7206 0.0332617729824 ko05144 Malaria 3/114 45/7206 0.0338301597287 ko05214 Glioma 4/114 79/7206 0.0360629114858 ko04810 Regulation of actin cytoskeleton 9/114 264/7206 0.03733297516 ko05230 Central carbon metabolism in cancer 4/114 81/7206 0.0389968519245 ko04062 Chemokine signaling pathway 7/114 201/7206 0.0397315123865 ko04912 GnRH signaling pathway 5/114 122/7206 0.0437147272122 ko04750 Inflammatory mediator regulation of TRP channels 5/114 122/7206 0.0437147272122 ko04066 HIF-1 signaling pathway 5/114 123/7206 0.0450136971786 ko05218 Melanoma 4/114 85/7206 0.0452640763103 ko00591 Linoleic acid metabolism 2/114 22/7206 0.0466476998677 ko05210 Colorectal cancer 4/114 86/7206 0.0469140765938 ko04917 Prolactin signaling pathway 4/114 87/7206 0.0485973024825 ko04212 Longevity regulating pathway - worm 4/114 87/7206 0.0485973024825 ko00590 Arachidonic acid metabolism 3/114 52/7206 0.0487000332891