ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 112/793 423/7206 3.49465094313e-20 ko04724 Glutamatergic synapse 58/793 152/7206 8.35023235128e-19 ko04721 Synaptic vesicle cycle 37/793 80/7206 1.31085261024e-15 ko05033 Nicotine addiction 30/793 56/7206 4.25350095249e-15 ko05032 Morphine addiction 43/793 110/7206 1.11677250702e-14 ko04727 GABAergic synapse 41/793 110/7206 3.11972942632e-13 ko04713 Circadian entrainment 45/793 136/7206 2.8709119561e-12 ko04728 Dopaminergic synapse 54/793 185/7206 5.36262198488e-12 ko04725 Cholinergic synapse 48/793 160/7206 2.90069619074e-11 ko04911 Insulin secretion 38/793 117/7206 2.73817814501e-10 ko04723 Retrograde endocannabinoid signaling 47/793 175/7206 3.90704668903e-09 ko04024 cAMP signaling pathway 64/793 279/7206 6.5838323189e-09 ko04726 Serotonergic synapse 38/793 137/7206 3.77372858744e-08 ko04020 Calcium signaling pathway 57/793 265/7206 3.91374416741e-07 ko04921 Oxytocin signaling pathway 47/793 209/7206 1.42441870892e-06 ko05031 Amphetamine addiction 26/793 91/7206 2.95982969924e-06 ko04710 Circadian rhythm 16/793 43/7206 5.98971957128e-06 ko03010 Ribosome 1/793 129/7206 6.61861550833e-06 ko04970 Salivary secretion 26/793 95/7206 7.0775172772e-06 ko05322 Systemic lupus erythematosus 2/793 151/7206 8.32881051979e-06 ko05203 Viral carcinogenesis 10/793 277/7206 8.51052474726e-06 ko04261 Adrenergic signaling in cardiomyocytes 44/793 205/7206 1.15225763484e-05 ko04070 Phosphatidylinositol signaling system 28/793 112/7206 2.25149064245e-05 ko04120 Ubiquitin mediated proteolysis 2/793 138/7206 2.54387561962e-05 ko04964 Proximal tubule bicarbonate reclamation 12/793 29/7206 2.54666244651e-05 ko04966 Collecting duct acid secretion 11/793 26/7206 4.34751996789e-05 ko03013 RNA transport 4/793 166/7206 4.739972982e-05 ko05030 Cocaine addiction 20/793 73/7206 7.86796461677e-05 ko04514 Cell adhesion molecules (CAMs) 30/793 130/7206 8.89388006502e-05 ko04971 Gastric acid secretion 24/793 98/7206 0.000122618128723 ko04720 Long-term potentiation 24/793 99/7206 0.000142392494447 ko05164 Influenza A 5/793 167/7206 0.000231045125287 ko04360 Axon guidance 44/793 233/7206 0.000265965678719 ko04972 Pancreatic secretion 25/793 111/7206 0.00036800187532 ko04022 cGMP-PKG signaling pathway 41/793 216/7206 0.00037679589608 ko05169 Epstein-Barr virus infection 9/793 206/7206 0.0009569554842 ko04072 Phospholipase D signaling pathway 37/793 197/7206 0.00108022966797 ko04960 Aldosterone-regulated sodium reabsorption 12/793 41/7206 0.00111324643686 ko04744 Phototransduction 11/793 36/7206 0.00120343589883 ko04014 Ras signaling pathway 48/793 279/7206 0.00165527387548 ko04730 Long-term depression 18/793 78/7206 0.00175286549288 ko04110 Cell cycle 5/793 145/7206 0.00176928772498 ko04745 Phototransduction - fly 11/793 38/7206 0.00196289225771 ko05168 Herpes simplex infection 8/793 182/7206 0.00244951170217 ko05110 Vibrio cholerae infection 15/793 63/7206 0.00345809848213 ko04750 Inflammatory mediator regulation of TRP channels 24/793 122/7206 0.00488100034871 ko04961 Endocrine and other factor-regulated calcium reabsorption 14/793 59/7206 0.00499708346063 ko04010 MAPK signaling pathway 51/793 321/7206 0.00604827691247 ko04925 Aldosterone synthesis and secretion 21/793 105/7206 0.00663793653474 ko05014 Amyotrophic lateral sclerosis (ALS) 16/793 74/7206 0.00753950292139 ko04141 Protein processing in endoplasmic reticulum 10/793 184/7206 0.0117930271993 ko05162 Measles 5/793 120/7206 0.011808358694 ko04621 NOD-like receptor signaling pathway 8/793 157/7206 0.0137667980835 ko04612 Antigen processing and presentation 2/793 77/7206 0.0153696467658 ko05205 Proteoglycans in cancer 18/793 271/7206 0.0172909464924 ko04976 Bile secretion 16/793 80/7206 0.0175094579312 ko04657 IL-17 signaling pathway 3/793 87/7206 0.0230261821656 ko00562 Inositol phosphate metabolism 17/793 89/7206 0.0245052260569 ko00280 Valine, leucine and isoleucine degradation 1/793 54/7206 0.0266274830696 ko04071 Sphingolipid signaling pathway 27/793 162/7206 0.0296384949359 ko04932 Non-alcoholic fatty liver disease (NAFLD) 11/793 182/7206 0.030046915355 ko05217 Basal cell carcinoma 2/793 68/7206 0.0302112888434 ko04540 Gap junction 22/793 128/7206 0.0315170828961 ko04742 Taste transduction 12/793 61/7206 0.0385186712434 ko04626 Plant-pathogen interaction 5/793 18/7206 0.0403753053708 ko04973 Carbohydrate digestion and absorption 9/793 42/7206 0.0433861328888 ko04930 Type II diabetes mellitus 11/793 54/7206 0.044660973078 ko04711 Circadian rhythm - fly 4/793 13/7206 0.0462705188812 ko05230 Central carbon metabolism in cancer 15/793 81/7206 0.0463821286768 ko05161 Hepatitis B 11/793 173/7206 0.0485964634529 ko05224 Breast cancer 11/793 174/7206 0.0487900147605