ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 23/192 152/7206 8.54139979326e-12 ko04713 Circadian entrainment 19/192 136/7206 2.4907319481e-09 ko05032 Morphine addiction 17/192 110/7206 3.72884430466e-09 ko04723 Retrograde endocannabinoid signaling 21/192 175/7206 5.80537711435e-09 ko04728 Dopaminergic synapse 21/192 185/7206 1.58538360325e-08 ko04727 GABAergic synapse 15/192 110/7206 1.78849768436e-07 ko05033 Nicotine addiction 11/192 56/7206 1.88658503216e-07 ko04072 Phospholipase D signaling pathway 20/192 197/7206 2.3137473266e-07 ko04925 Aldosterone synthesis and secretion 14/192 105/7206 6.18753742576e-07 ko04070 Phosphatidylinositol signaling system 14/192 112/7206 1.37562311997e-06 ko04915 Estrogen signaling pathway 15/192 131/7206 1.77669735155e-06 ko04020 Calcium signaling pathway 22/192 265/7206 1.84170117101e-06 ko04720 Long-term potentiation 13/192 99/7206 1.88613974571e-06 ko04080 Neuroactive ligand-receptor interaction 29/192 423/7206 2.05219394238e-06 ko05031 Amphetamine addiction 12/192 91/7206 4.53935397663e-06 ko05231 Choline metabolism in cancer 14/192 134/7206 1.16977567377e-05 ko04024 cAMP signaling pathway 21/192 279/7206 1.48539155077e-05 ko04914 Progesterone-mediated oocyte maturation 12/192 104/7206 1.83717784422e-05 ko04725 Cholinergic synapse 15/192 160/7206 2.11496837029e-05 ko04742 Taste transduction 9/192 61/7206 2.93745813328e-05 ko04015 Rap1 signaling pathway 20/192 278/7206 4.60028511312e-05 ko04022 cGMP-PKG signaling pathway 17/192 216/7206 5.77631258121e-05 ko04911 Insulin secretion 12/192 117/7206 6.01862896932e-05 ko04912 GnRH signaling pathway 12/192 122/7206 9.07417489818e-05 ko04261 Adrenergic signaling in cardiomyocytes 16/192 205/7206 0.000106010116076 ko05030 Cocaine addiction 9/192 73/7206 0.00012483918634 ko04371 Apelin signaling pathway 14/192 177/7206 0.000251296767741 ko04062 Chemokine signaling pathway 15/192 201/7206 0.000286090689156 ko00510 N-Glycan biosynthesis 7/192 50/7206 0.000323337306509 ko04211 Longevity regulating pathway 11/192 123/7206 0.000412301755127 ko04921 Oxytocin signaling pathway 15/192 209/7206 0.000435186512567 ko00562 Inositol phosphate metabolism 9/192 89/7206 0.000566596436664 ko04540 Gap junction 11/192 128/7206 0.000579954934878 ko04012 ErbB signaling pathway 10/192 109/7206 0.000616139747997 ko04970 Salivary secretion 9/192 95/7206 0.000913188719044 ko04923 Regulation of lipolysis in adipocytes 8/192 77/7206 0.0009579373083 ko04730 Long-term depression 8/192 78/7206 0.00104351792747 ko04971 Gastric acid secretion 9/192 98/7206 0.00114207150783 ko04320 Dorso-ventral axis formation 5/192 31/7206 0.00123226548859 ko04611 Platelet activation 12/192 163/7206 0.00130900249771 ko04916 Melanogenesis 11/192 142/7206 0.00137484629828 ko04750 Inflammatory mediator regulation of TRP channels 10/192 122/7206 0.00147744003108 ko05034 Alcoholism 15/192 238/7206 0.00165512177182 ko01522 Endocrine resistance 10/192 124/7206 0.0016707884048 ko04213 Longevity regulating pathway - multiple species 8/192 86/7206 0.00197066786807 ko04918 Thyroid hormone synthesis 8/192 86/7206 0.00197066786807 ko04270 Vascular smooth muscle contraction 11/192 154/7206 0.00262688295109 ko04144 Endocytosis 19/192 342/7206 0.00267485849574 ko04930 Type II diabetes mellitus 6/192 54/7206 0.00295037216811 ko04726 Serotonergic synapse 10/192 137/7206 0.0034854631069 ko04010 MAPK signaling pathway 18/192 321/7206 0.00361605997972 ko00513 Various types of N-glycan biosynthesis 5/192 42/7206 0.00487046597572 ko05214 Glioma 7/192 79/7206 0.00490669265212 ko04666 Fc gamma R-mediated phagocytosis 9/192 122/7206 0.00512628163212 ko04740 Olfactory transduction 7/192 80/7206 0.00525896354617 ko00512 Mucin type O-glycan biosynthesis 4/192 29/7206 0.00688538210037 ko05142 Chagas disease (American trypanosomiasis) 9/192 130/7206 0.00771890813422 ko04924 Renin secretion 7/192 86/7206 0.00778575625946 ko04917 Prolactin signaling pathway 7/192 87/7206 0.00828135574325 ko04972 Pancreatic secretion 8/192 111/7206 0.00934274822363 ko05414 Dilated cardiomyopathy 8/192 112/7206 0.00983846019158 ko04071 Sphingolipid signaling pathway 10/192 162/7206 0.0111014609478 ko04114 Oocyte meiosis 9/192 139/7206 0.0117201086028 ko04011 MAPK signaling pathway - yeast 5/192 53/7206 0.0129930285961 ko04745 Phototransduction - fly 4/192 38/7206 0.0177799564928 ko04014 Ras signaling pathway 14/192 279/7206 0.0207897996652 ko01521 EGFR tyrosine kinase inhibitor resistance 7/192 106/7206 0.022705673304 ko04973 Carbohydrate digestion and absorption 4/192 42/7206 0.0248424568542 ko04913 Ovarian steroidogenesis 5/192 63/7206 0.025749731116 ko00561 Glycerolipid metabolism 5/192 63/7206 0.025749731116 ko00515 Mannose type O-glycan biosynthesis 3/192 25/7206 0.0278340030226 ko05223 Non-small cell lung cancer 5/192 66/7206 0.0307335349886 ko04120 Ubiquitin mediated proteolysis 8/192 138/7206 0.0307414098712 ko04360 Axon guidance 12/192 233/7206 0.034190306097 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 3/192 28/7206 0.0374178474284 ko04722 Neurotrophin signaling pathway 9/192 160/7206 0.0394969229919 ko00514 Other types of O-glycan biosynthesis 3/192 30/7206 0.0446251155185 ko04660 T cell receptor signaling pathway 7/192 124/7206 0.0472965724464 ko00564 Glycerophospholipid metabolism 6/192 99/7206 0.0482222783097 ko04910 Insulin signaling pathway 9/192 172/7206 0.0490627743028