ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	167/1058	423/7206	1.93108992529e-38
ko04721	Synaptic vesicle cycle	55/1058	80/7206	3.91160113017e-28
ko04724	Glutamatergic synapse	77/1058	152/7206	3.74620997753e-26
ko05033	Nicotine addiction	40/1058	56/7206	9.48704229043e-22
ko04713	Circadian entrainment	64/1058	136/7206	9.98941262429e-20
ko04728	Dopaminergic synapse	76/1058	185/7206	7.41359816062e-19
ko04727	GABAergic synapse	54/1058	110/7206	7.35003202023e-18
ko05032	Morphine addiction	54/1058	110/7206	7.35003202023e-18
ko04742	Taste transduction	36/1058	61/7206	1.27099059215e-15
ko04725	Cholinergic synapse	64/1058	160/7206	2.24665412175e-15
ko04723	Retrograde endocannabinoid signaling	65/1058	175/7206	9.0041421698e-14
ko04911	Insulin secretion	50/1058	117/7206	1.32454421506e-13
ko04024	cAMP signaling pathway	86/1058	279/7206	2.46689906394e-12
ko04726	Serotonergic synapse	52/1058	137/7206	1.11205471622e-11
ko04921	Oxytocin signaling pathway	68/1058	209/7206	5.16660323793e-11
ko04740	Olfactory transduction	35/1058	80/7206	2.96429710108e-10
ko04261	Adrenergic signaling in cardiomyocytes	65/1058	205/7206	3.32047098703e-10
ko05031	Amphetamine addiction	37/1058	91/7206	1.15474474839e-09
ko04744	Phototransduction	21/1058	36/7206	1.62244809507e-09
ko04020	Calcium signaling pathway	76/1058	265/7206	2.52081390507e-09
ko03040	Spliceosome	1/1058	145/7206	3.51418313686e-09
ko04720	Long-term potentiation	38/1058	99/7206	4.77779031663e-09
ko04966	Collecting duct acid secretion	17/1058	26/7206	5.11030529869e-09
ko04970	Salivary secretion	35/1058	95/7206	6.57084571252e-08
ko05203	Viral carcinogenesis	13/1058	277/7206	8.96112415839e-08
ko05168	Herpes simplex infection	5/1058	182/7206	1.07236489462e-07
ko04120	Ubiquitin mediated proteolysis	3/1058	138/7206	1.1865526087e-06
ko04260	Cardiac muscle contraction	33/1058	98/7206	1.84282038125e-06
ko05030	Cocaine addiction	27/1058	73/7206	1.91478800006e-06
ko04060	Cytokine-cytokine receptor interaction	8/1058	191/7206	3.68627124178e-06
ko05164	Influenza A	6/1058	167/7206	3.9570604602e-06
ko03013	RNA transport	6/1058	166/7206	3.96844205324e-06
ko04925	Aldosterone synthesis and secretion	34/1058	105/7206	4.19403022106e-06
ko04010	MAPK signaling pathway	77/1058	321/7206	7.47036870292e-06
ko04971	Gastric acid secretion	32/1058	98/7206	7.93173740177e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1058	74/7206	8.8438487802e-06
ko04540	Gap junction	38/1058	128/7206	1.15382328982e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1058	29/7206	1.77323537492e-05
ko04360	Axon guidance	59/1058	233/7206	1.81445502265e-05
ko04924	Renin secretion	28/1058	86/7206	2.20151655219e-05
ko04141	Protein processing in endoplasmic reticulum	9/1058	184/7206	3.10159077763e-05
ko05322	Systemic lupus erythematosus	6/1058	151/7206	3.49722725901e-05
ko04514	Cell adhesion molecules (CAMs)	37/1058	130/7206	4.45158232601e-05
ko04976	Bile secretion	26/1058	80/7206	4.52585820273e-05
ko05110	Vibrio cholerae infection	22/1058	63/7206	4.78756095423e-05
ko05162	Measles	4/1058	120/7206	7.28443813223e-05
ko04022	cGMP-PKG signaling pathway	52/1058	216/7206	0.000189532416286
ko04621	NOD-like receptor signaling pathway	8/1058	157/7206	0.000219666519271
ko04730	Long-term depression	24/1058	78/7206	0.000272579889194
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1058	14/7206	0.000276641084115
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/1058	79/7206	0.000316625513062
ko04626	Plant-pathogen interaction	9/1058	18/7206	0.000425758156975
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1058	59/7206	0.000590995969525
ko04745	Phototransduction - fly	14/1058	38/7206	0.000607634062183
ko04610	Complement and coagulation cascades	2/1058	79/7206	0.000626169946672
ko03008	Ribosome biogenesis in eukaryotes	2/1058	79/7206	0.000626169946672
ko00240	Pyrimidine metabolism	5/1058	110/7206	0.00100594240119
ko05169	Epstein-Barr virus infection	15/1058	206/7206	0.00132794185033
ko05120	Epithelial cell signaling in Helicobacter pylori infection	25/1058	92/7206	0.00159827530887
ko05414	Dilated cardiomyopathy	29/1058	112/7206	0.00172020849602
ko04014	Ras signaling pathway	60/1058	279/7206	0.00180025912298
ko04064	NF-kappa B signaling pathway	4/1058	96/7206	0.00193629921993
ko04110	Cell cycle	9/1058	145/7206	0.00194932638066
ko04214	Apoptosis - fly	2/1058	72/7206	0.00207177661511
ko05321	Inflammatory bowel disease (IBD)	1/1058	56/7206	0.00214849976164
ko04915	Estrogen signaling pathway	32/1058	131/7206	0.00263965095945
ko04972	Pancreatic secretion	28/1058	111/7206	0.00281750812251
ko00480	Glutathione metabolism	1/1058	55/7206	0.00328961392589
ko04146	Peroxisome	4/1058	89/7206	0.00374366564918
ko04750	Inflammatory mediator regulation of TRP channels	30/1058	122/7206	0.0040823515008
ko04640	Hematopoietic cell lineage	2/1058	64/7206	0.0042236421884
ko05140	Leishmaniasis	3/1058	75/7206	0.00487313235671
ko04612	Antigen processing and presentation	3/1058	77/7206	0.00509800993895
ko01200	Carbon metabolism	8/1058	128/7206	0.00511595348593
ko04950	Maturity onset diabetes of the young	10/1058	29/7206	0.00626315236893
ko00260	Glycine, serine and threonine metabolism	1/1058	48/7206	0.00714221230851
ko03018	RNA degradation	4/1058	84/7206	0.00752865745857
ko04145	Phagosome	36/1058	162/7206	0.00937217746917
ko00071	Fatty acid degradation	1/1058	45/7206	0.0106469771767
ko03420	Nucleotide excision repair	1/1058	46/7206	0.0107190574496
ko05166	HTLV-I infection	28/1058	292/7206	0.0111059776337
ko04978	Mineral absorption	12/1058	40/7206	0.0116600199633
ko05161	Hepatitis B	14/1058	173/7206	0.0119438857434
ko04371	Apelin signaling pathway	38/1058	177/7206	0.0130899136155
ko04140	Autophagy - animal	13/1058	164/7206	0.0134650760675
ko05205	Proteoglycans in cancer	26/1058	271/7206	0.0141505368393
ko01524	Platinum drug resistance	4/1058	76/7206	0.0143638744492
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1058	100/7206	0.0144664628519
ko03022	Basal transcription factors	1/1058	44/7206	0.0163345397423
ko00280	Valine, leucine and isoleucine degradation	2/1058	54/7206	0.0188569007333
ko04115	p53 signaling pathway	4/1058	74/7206	0.0199494030824
ko00310	Lysine degradation	4/1058	73/7206	0.0199533438014
ko05323	Rheumatoid arthritis	21/1058	89/7206	0.0229303822697
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1058	40/7206	0.0235187327053
ko04512	ECM-receptor interaction	19/1058	79/7206	0.0243479488163
ko04668	TNF signaling pathway	9/1058	120/7206	0.0259868908101
ko04138	Autophagy - yeast	5/1058	81/7206	0.0264508202725
ko00380	Tryptophan metabolism	2/1058	50/7206	0.0268252663483
ko00590	Arachidonic acid metabolism	2/1058	52/7206	0.0278220685314
ko04015	Rap1 signaling pathway	54/1058	278/7206	0.0302304343989
ko00982	Drug metabolism - cytochrome P450	1/1058	37/7206	0.0347795309084
ko04923	Regulation of lipolysis in adipocytes	18/1058	77/7206	0.0354828900259
ko00270	Cysteine and methionine metabolism	2/1058	47/7206	0.0384738092741
ko04916	Melanogenesis	30/1058	142/7206	0.0406176487831
ko04210	Apoptosis	17/1058	180/7206	0.0427832151672
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1058	182/7206	0.0430740392594
ko04657	IL-17 signaling pathway	6/1058	87/7206	0.0456714634698