ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	181/1105	423/7206	6.69596519738e-45
ko04724	Glutamatergic synapse	84/1105	152/7206	1.18505964072e-30
ko05033	Nicotine addiction	46/1105	56/7206	1.15608054645e-28
ko05032	Morphine addiction	66/1105	110/7206	3.98754492922e-27
ko04727	GABAergic synapse	61/1105	110/7206	1.27180401821e-22
ko04713	Circadian entrainment	65/1105	136/7206	1.93523934805e-19
ko04728	Dopaminergic synapse	78/1105	185/7206	5.65845438928e-19
ko04723	Retrograde endocannabinoid signaling	75/1105	175/7206	8.85439353941e-19
ko04721	Synaptic vesicle cycle	46/1105	80/7206	3.33869758153e-18
ko04024	cAMP signaling pathway	99/1105	279/7206	2.23812903947e-17
ko04725	Cholinergic synapse	67/1105	160/7206	2.88427990407e-16
ko04360	Axon guidance	82/1105	233/7206	2.8944614653e-14
ko04020	Calcium signaling pathway	87/1105	265/7206	4.13420522665e-13
ko04911	Insulin secretion	49/1105	117/7206	3.1475144803e-12
ko04261	Adrenergic signaling in cardiomyocytes	70/1105	205/7206	1.04284953901e-11
ko04742	Taste transduction	32/1105	61/7206	1.3831815028e-11
ko04921	Oxytocin signaling pathway	70/1105	209/7206	3.17853497339e-11
ko04726	Serotonergic synapse	52/1105	137/7206	5.95445680793e-11
ko03040	Spliceosome	1/1105	145/7206	1.36792289582e-09
ko04744	Phototransduction	21/1105	36/7206	3.65747762172e-09
ko05031	Amphetamine addiction	35/1105	91/7206	5.66974451484e-08
ko05203	Viral carcinogenesis	14/1105	277/7206	8.81076686431e-08
ko03013	RNA transport	5/1105	166/7206	3.08674827531e-07
ko04970	Salivary secretion	35/1105	95/7206	3.19101169954e-07
ko05030	Cocaine addiction	29/1105	73/7206	3.47855099193e-07
ko05322	Systemic lupus erythematosus	4/1105	151/7206	4.94181409018e-07
ko04022	cGMP-PKG signaling pathway	60/1105	216/7206	1.90000869049e-06
ko04720	Long-term potentiation	34/1105	99/7206	3.12877882035e-06
ko05168	Herpes simplex infection	8/1105	182/7206	3.43900043e-06
ko04010	MAPK signaling pathway	80/1105	321/7206	5.13339258182e-06
ko04141	Protein processing in endoplasmic reticulum	9/1105	184/7206	1.05973132827e-05
ko04120	Ubiquitin mediated proteolysis	5/1105	138/7206	1.32917137863e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1105	74/7206	2.37676924157e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1105	79/7206	2.59960621675e-05
ko05414	Dilated cardiomyopathy	34/1105	112/7206	5.08270364621e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1105	79/7206	5.20642654881e-05
ko04060	Cytokine-cytokine receptor interaction	11/1105	191/7206	5.92897764449e-05
ko04621	NOD-like receptor signaling pathway	8/1105	157/7206	7.62914638207e-05
ko04925	Aldosterone synthesis and secretion	32/1105	105/7206	9.14689477061e-05
ko04972	Pancreatic secretion	33/1105	111/7206	9.38898895315e-05
ko04260	Cardiac muscle contraction	30/1105	98/7206	0.000106598391118
ko04971	Gastric acid secretion	30/1105	98/7206	0.000106598391118
ko04514	Cell adhesion molecules (CAMs)	37/1105	130/7206	0.000110504443256
ko04070	Phosphatidylinositol signaling system	33/1105	112/7206	0.00015822950033
ko04064	NF-kappa B signaling pathway	3/1105	96/7206	0.000169454430378
ko04072	Phospholipase D signaling pathway	50/1105	197/7206	0.0001872047202
ko04966	Collecting duct acid secretion	12/1105	26/7206	0.000189699374031
ko04730	Long-term depression	25/1105	78/7206	0.000189816657919
ko05164	Influenza A	10/1105	167/7206	0.000289888821128
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1105	14/7206	0.000376860312482
ko04146	Peroxisome	3/1105	89/7206	0.000527506473927
ko05169	Epstein-Barr virus infection	15/1105	206/7206	0.000556164663136
ko04391	Hippo signaling pathway - fly	26/1105	90/7206	0.000975540179341
ko05205	Proteoglycans in cancer	23/1105	271/7206	0.00102010972138
ko04540	Gap junction	34/1105	128/7206	0.00110793652777
ko05110	Vibrio cholerae infection	20/1105	63/7206	0.00113245753312
ko04014	Ras signaling pathway	63/1105	279/7206	0.00120192988354
ko00240	Pyrimidine metabolism	6/1105	110/7206	0.0019720308069
ko00280	Valine, leucine and isoleucine degradation	1/1105	54/7206	0.00206540814297
ko00480	Glutathione metabolism	1/1105	55/7206	0.00209222955135
ko04612	Antigen processing and presentation	3/1105	77/7206	0.00229208088096
ko04924	Renin secretion	24/1105	86/7206	0.00236121304046
ko04640	Hematopoietic cell lineage	2/1105	64/7206	0.00279806289665
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1105	100/7206	0.00289391106901
ko04915	Estrogen signaling pathway	33/1105	131/7206	0.00303784062781
ko00590	Arachidonic acid metabolism	1/1105	52/7206	0.0031132115831
ko04923	Regulation of lipolysis in adipocytes	22/1105	77/7206	0.00353832128518
ko03018	RNA degradation	4/1105	84/7206	0.00360615035179
ko04740	Olfactory transduction	22/1105	80/7206	0.00452745301738
ko00330	Arginine and proline metabolism	2/1105	61/7206	0.00628185269131
ko05162	Measles	8/1105	120/7206	0.00673686142738
ko03420	Nucleotide excision repair	1/1105	46/7206	0.00693817041068
ko00260	Glycine, serine and threonine metabolism	1/1105	48/7206	0.00735477155042
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1105	59/7206	0.00951910315394
ko01524	Platinum drug resistance	4/1105	76/7206	0.0100199503805
ko03022	Basal transcription factors	1/1105	44/7206	0.0104233602495
ko00071	Fatty acid degradation	1/1105	45/7206	0.0107864582119
ko04745	Phototransduction - fly	12/1105	38/7206	0.0107924869312
ko04140	Autophagy - animal	14/1105	164/7206	0.0116072073601
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1105	26/7206	0.0120587485508
ko05140	Leishmaniasis	4/1105	75/7206	0.0143692647071
ko04510	Focal adhesion	24/1105	240/7206	0.0177209646356
ko05131	Shigellosis	5/1105	82/7206	0.0194084119971
ko04214	Apoptosis - fly	4/1105	72/7206	0.0198736070851
ko04930	Type II diabetes mellitus	15/1105	54/7206	0.0204820700939
ko04630	Jak-STAT signaling pathway	11/1105	132/7206	0.0205606031542
ko00630	Glyoxylate and dicarboxylate metabolism	1/1105	38/7206	0.0229695048666
ko03410	Base excision repair	1/1105	38/7206	0.0229695048666
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1105	40/7206	0.0243487053962
ko05161	Hepatitis B	16/1105	173/7206	0.0243717710213
ko05133	Pertussis	6/1105	87/7206	0.0244024677223
ko04371	Apelin signaling pathway	38/1105	177/7206	0.0262556301285
ko05219	Bladder cancer	2/1105	48/7206	0.0262756991393
ko04217	Necroptosis	17/1105	178/7206	0.0270800750127
ko04976	Bile secretion	20/1105	80/7206	0.0271611889173
ko04210	Apoptosis	17/1105	180/7206	0.0272066822107
ko00380	Tryptophan metabolism	2/1105	50/7206	0.0274811481924
ko00512	Mucin type O-glycan biosynthesis	9/1105	29/7206	0.0331607475763
ko04964	Proximal tubule bicarbonate reclamation	9/1105	29/7206	0.0331607475763
ko01200	Carbon metabolism	11/1105	128/7206	0.0344588691428
ko04110	Cell cycle	13/1105	145/7206	0.0351430712931
ko04115	p53 signaling pathway	5/1105	74/7206	0.0352859580466
ko00982	Drug metabolism - cytochrome P450	1/1105	37/7206	0.035553987519
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1105	182/7206	0.0371762293641
ko00562	Inositol phosphate metabolism	21/1105	89/7206	0.0372533269716
ko05144	Malaria	2/1105	45/7206	0.037769855912
ko00620	Pyruvate metabolism	2/1105	46/7206	0.0380358082796
ko04750	Inflammatory mediator regulation of TRP channels	27/1105	122/7206	0.0420619966691
ko05145	Toxoplasmosis	11/1105	126/7206	0.0447070282626
ko04144	Endocytosis	66/1105	342/7206	0.0451657124068
ko00310	Lysine degradation	5/1105	73/7206	0.0482643801867
ko05210	Colorectal cancer	20/1105	86/7206	0.0492022651013