ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1180	423/7206	1.08201757533e-50
ko04724	Glutamatergic synapse	83/1180	152/7206	1.0518247864e-27
ko05033	Nicotine addiction	45/1180	56/7206	4.97769337297e-26
ko04713	Circadian entrainment	74/1180	136/7206	1.14032142681e-24
ko05032	Morphine addiction	62/1180	110/7206	6.31526143144e-22
ko04721	Synaptic vesicle cycle	51/1180	80/7206	1.32563958371e-21
ko04727	GABAergic synapse	60/1180	110/7206	2.81534372067e-20
ko04728	Dopaminergic synapse	82/1180	185/7206	1.05044907132e-19
ko04725	Cholinergic synapse	73/1180	160/7206	1.5792843466e-18
ko04020	Calcium signaling pathway	98/1180	265/7206	1.36815966861e-16
ko04024	cAMP signaling pathway	100/1180	279/7206	9.92142934996e-16
ko04911	Insulin secretion	56/1180	117/7206	1.25371389787e-15
ko04723	Retrograde endocannabinoid signaling	72/1180	175/7206	2.54661120751e-15
ko04742	Taste transduction	37/1180	61/7206	5.40949201186e-15
ko04921	Oxytocin signaling pathway	79/1180	209/7206	3.11698113884e-14
ko04726	Serotonergic synapse	58/1180	137/7206	3.25934052759e-13
ko04970	Salivary secretion	44/1180	95/7206	6.19232883423e-12
ko04261	Adrenergic signaling in cardiomyocytes	71/1180	205/7206	8.50743208509e-11
ko05031	Amphetamine addiction	40/1180	91/7206	4.13537518659e-10
ko05203	Viral carcinogenesis	13/1180	277/7206	2.15744948562e-09
ko04720	Long-term potentiation	41/1180	99/7206	2.24426317481e-09
ko03040	Spliceosome	2/1180	145/7206	4.18651576248e-09
ko04744	Phototransduction	21/1180	36/7206	1.23466592377e-08
ko04971	Gastric acid secretion	39/1180	98/7206	2.10562699729e-08
ko05168	Herpes simplex infection	6/1180	182/7206	3.66114403773e-08
ko04060	Cytokine-cytokine receptor interaction	7/1180	191/7206	4.5914805753e-08
ko04925	Aldosterone synthesis and secretion	40/1180	105/7206	6.47709428953e-08
ko04022	cGMP-PKG signaling pathway	66/1180	216/7206	1.70682759866e-07
ko04360	Axon guidance	69/1180	233/7206	3.07053557277e-07
ko04740	Olfactory transduction	32/1180	80/7206	3.39889973427e-07
ko05164	Influenza A	6/1180	167/7206	3.66759967244e-07
ko05322	Systemic lupus erythematosus	5/1180	151/7206	5.80645099615e-07
ko04120	Ubiquitin mediated proteolysis	4/1180	138/7206	6.27900950038e-07
ko04966	Collecting duct acid secretion	15/1180	26/7206	1.92289088589e-06
ko03013	RNA transport	7/1180	166/7206	1.93018520413e-06
ko04621	NOD-like receptor signaling pathway	7/1180	157/7206	5.51462447843e-06
ko04514	Cell adhesion molecules (CAMs)	42/1180	130/7206	6.10927610741e-06
ko05030	Cocaine addiction	28/1180	73/7206	6.86708312273e-06
ko04730	Long-term depression	29/1180	78/7206	7.64203343255e-06
ko04540	Gap junction	41/1180	128/7206	9.65335818771e-06
ko04924	Renin secretion	31/1180	86/7206	1.04167934781e-05
ko04010	MAPK signaling pathway	82/1180	321/7206	1.8988392111e-05
ko04972	Pancreatic secretion	36/1180	111/7206	2.44955746022e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1180	79/7206	3.88541373544e-05
ko04976	Bile secretion	28/1180	80/7206	4.54618588016e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1180	29/7206	6.27104408831e-05
ko04260	Cardiac muscle contraction	32/1180	98/7206	8.01965177572e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1180	74/7206	8.89703582656e-05
ko04110	Cell cycle	8/1180	145/7206	9.75876051317e-05
ko05169	Epstein-Barr virus infection	15/1180	206/7206	0.000121805678636
ko04745	Phototransduction - fly	16/1180	38/7206	0.000147236608186
ko04610	Complement and coagulation cascades	2/1180	79/7206	0.000171962627254
ko03008	Ribosome biogenesis in eukaryotes	2/1180	79/7206	0.000171962627254
ko04141	Protein processing in endoplasmic reticulum	13/1180	184/7206	0.00024506495632
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1180	59/7206	0.000280078015656
ko04978	Mineral absorption	16/1180	40/7206	0.000300509551986
ko05161	Hepatitis B	12/1180	173/7206	0.000352528641985
ko05110	Vibrio cholerae infection	22/1180	63/7206	0.000414457540711
ko05414	Dilated cardiomyopathy	33/1180	112/7206	0.000439957933121
ko05166	HTLV-I infection	27/1180	292/7206	0.000483778713579
ko04214	Apoptosis - fly	2/1180	72/7206	0.000575874009953
ko05205	Proteoglycans in cancer	25/1180	271/7206	0.000768367171128
ko04146	Peroxisome	4/1180	89/7206	0.000827678281388
ko04626	Plant-pathogen interaction	9/1180	18/7206	0.000975257813079
ko04070	Phosphatidylinositol signaling system	32/1180	112/7206	0.00111229373386
ko04014	Ras signaling pathway	66/1180	279/7206	0.00125621975058
ko04064	NF-kappa B signaling pathway	5/1180	96/7206	0.00127998159078
ko05140	Leishmaniasis	3/1180	75/7206	0.00149370129595
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1180	100/7206	0.00149391496821
ko04612	Antigen processing and presentation	3/1180	77/7206	0.00158134444102
ko04630	Jak-STAT signaling pathway	9/1180	132/7206	0.00181333796192
ko05162	Measles	8/1180	120/7206	0.00254886270559
ko00240	Pyrimidine metabolism	7/1180	110/7206	0.00257718125158
ko04330	Notch signaling pathway	2/1180	62/7206	0.00274788204738
ko04750	Inflammatory mediator regulation of TRP channels	33/1180	122/7206	0.00275873189285
ko04371	Apelin signaling pathway	44/1180	177/7206	0.00373133645772
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1180	182/7206	0.00425176041142
ko03420	Nucleotide excision repair	1/1180	46/7206	0.00441287845763
ko04657	IL-17 signaling pathway	5/1180	87/7206	0.00504807656509
ko04922	Glucagon signaling pathway	33/1180	128/7206	0.00545853287966
ko00480	Glutathione metabolism	2/1180	55/7206	0.00568046107053
ko05321	Inflammatory bowel disease (IBD)	2/1180	56/7206	0.00571977511963
ko05215	Prostate cancer	8/1180	111/7206	0.00627651389294
ko03022	Basal transcription factors	1/1180	44/7206	0.0066963293771
ko03018	RNA degradation	5/1180	84/7206	0.00697459905458
ko00071	Fatty acid degradation	1/1180	45/7206	0.00702070292752
ko04270	Vascular smooth muscle contraction	38/1180	154/7206	0.00783670803752
ko04915	Estrogen signaling pathway	33/1180	131/7206	0.00848904258546
ko04622	RIG-I-like receptor signaling pathway	3/1180	62/7206	0.00921479659327
ko04640	Hematopoietic cell lineage	3/1180	64/7206	0.00965146604009
ko04217	Necroptosis	17/1180	178/7206	0.0102635047182
ko04210	Apoptosis	17/1180	180/7206	0.0103643550013
ko00380	Tryptophan metabolism	2/1180	50/7206	0.0120805899729
ko04658	Th1 and Th2 cell differentiation	7/1180	96/7206	0.0121155999995
ko05133	Pertussis	6/1180	87/7206	0.0127896619431
ko04668	TNF signaling pathway	10/1180	120/7206	0.0128069129738
ko00330	Arginine and proline metabolism	3/1180	61/7206	0.0135222937295
ko04930	Type II diabetes mellitus	16/1180	54/7206	0.0146789621119
ko03410	Base excision repair	1/1180	38/7206	0.0148478507879
ko05418	Fluid shear stress and atherosclerosis	17/1180	173/7206	0.0165291023301
ko04974	Protein digestion and absorption	25/1180	96/7206	0.0171459080707
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1180	14/7206	0.01745257963
ko05220	Chronic myeloid leukemia	6/1180	85/7206	0.0174848969595
ko05219	Bladder cancer	2/1180	48/7206	0.0175983997426
ko01524	Platinum drug resistance	5/1180	76/7206	0.0183964160411
ko04072	Phospholipase D signaling pathway	45/1180	197/7206	0.0186090828435
ko05200	Pathways in cancer	62/1180	492/7206	0.0193749840928
ko05217	Basal cell carcinoma	4/1180	68/7206	0.0195090905272
ko05145	Toxoplasmosis	11/1180	126/7206	0.0201809309105
ko04620	Toll-like receptor signaling pathway	8/1180	100/7206	0.0202034816229
ko05131	Shigellosis	6/1180	82/7206	0.0236266498292
ko05212	Pancreatic cancer	6/1180	83/7206	0.0239503100887
ko00310	Lysine degradation	5/1180	73/7206	0.0251167156206
ko05144	Malaria	2/1180	45/7206	0.0254018024198
ko04115	p53 signaling pathway	5/1180	74/7206	0.0255366074481
ko04923	Regulation of lipolysis in adipocytes	20/1180	77/7206	0.0291990659562
ko05222	Small cell lung cancer	7/1180	89/7206	0.0295154576486
ko01200	Carbon metabolism	12/1180	128/7206	0.0296511806676
ko04350	TGF-beta signaling pathway	9/1180	103/7206	0.0318963219725
ko04140	Autophagy - animal	17/1180	164/7206	0.032888827003
ko04550	Signaling pathways regulating pluripotency of stem cells	17/1180	165/7206	0.0328949931224
ko04912	GnRH signaling pathway	29/1180	122/7206	0.034902556286
ko00500	Starch and sucrose metabolism	1/1180	35/7206	0.0351115446515
ko05206	MicroRNAs in cancer	19/1180	177/7206	0.039535252004
ko05340	Primary immunodeficiency	1/1180	30/7206	0.0492380474122