ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	46/485	152/7206	4.4488109664e-19
ko04080	Neuroactive ligand-receptor interaction	76/485	423/7206	4.27715291051e-16
ko04713	Circadian entrainment	39/485	136/7206	1.89970663299e-15
ko05033	Nicotine addiction	25/485	56/7206	2.16722793089e-15
ko04921	Oxytocin signaling pathway	45/485	209/7206	1.15288807806e-12
ko04261	Adrenergic signaling in cardiomyocytes	43/485	205/7206	9.53154907672e-12
ko04911	Insulin secretion	31/485	117/7206	1.59392238377e-11
ko04728	Dopaminergic synapse	40/485	185/7206	1.93338809278e-11
ko04723	Retrograde endocannabinoid signaling	36/485	175/7206	8.92006036095e-10
ko04721	Synaptic vesicle cycle	23/485	80/7206	1.22886052219e-09
ko04020	Calcium signaling pathway	46/485	265/7206	1.47476126076e-09
ko04727	GABAergic synapse	27/485	110/7206	2.15625332565e-09
ko04024	cAMP signaling pathway	46/485	279/7206	1.05217336076e-08
ko04725	Cholinergic synapse	32/485	160/7206	1.63477728287e-08
ko04022	cGMP-PKG signaling pathway	38/485	216/7206	2.92890431632e-08
ko04970	Salivary secretion	23/485	95/7206	4.5213973002e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	20/485	74/7206	4.78302295371e-08
ko04726	Serotonergic synapse	28/485	137/7206	8.1157401971e-08
ko05032	Morphine addiction	24/485	110/7206	1.93155378907e-07
ko05031	Amphetamine addiction	21/485	91/7206	4.19291348026e-07
ko04360	Axon guidance	37/485	233/7206	7.31267114179e-07
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/485	79/7206	7.59620842531e-07
ko04010	MAPK signaling pathway	46/485	321/7206	9.19214189625e-07
ko04720	Long-term potentiation	21/485	99/7206	1.84295474126e-06
ko04730	Long-term depression	18/485	78/7206	2.82758718258e-06
ko04260	Cardiac muscle contraction	20/485	98/7206	6.06952761027e-06
ko04971	Gastric acid secretion	20/485	98/7206	6.06952761027e-06
ko05410	Hypertrophic cardiomyopathy (HCM)	19/485	100/7206	3.01497210901e-05
ko04742	Taste transduction	14/485	61/7206	3.86360213977e-05
ko05168	Herpes simplex infection	1/485	182/7206	6.66495931566e-05
ko04922	Glucagon signaling pathway	21/485	128/7206	0.000112062922131
ko04514	Cell adhesion molecules (CAMs)	21/485	130/7206	0.000140684459509
ko04745	Phototransduction - fly	10/485	38/7206	0.000147725530747
ko05414	Dilated cardiomyopathy	19/485	112/7206	0.000149969409503
ko04550	Signaling pathways regulating pluripotency of stem cells	1/485	165/7206	0.000215381725625
ko04060	Cytokine-cytokine receptor interaction	2/485	191/7206	0.000332819210923
ko05322	Systemic lupus erythematosus	1/485	151/7206	0.000463233528401
ko04150	mTOR signaling pathway	2/485	184/7206	0.000474328209023
ko04924	Renin secretion	15/485	86/7206	0.000540654796781
ko04925	Aldosterone synthesis and secretion	17/485	105/7206	0.00058125694278
ko03040	Spliceosome	1/485	145/7206	0.00068087196929
ko05203	Viral carcinogenesis	6/485	277/7206	0.000830535296856
ko04740	Olfactory transduction	13/485	80/7206	0.00242687877353
ko04964	Proximal tubule bicarbonate reclamation	7/485	29/7206	0.00254651240198
ko05030	Cocaine addiction	12/485	73/7206	0.00318985700505
ko04972	Pancreatic secretion	16/485	111/7206	0.00332871212039
ko04270	Vascular smooth muscle contraction	20/485	154/7206	0.00479650699391
ko05161	Hepatitis B	3/485	173/7206	0.00495131094898
ko04961	Endocrine and other factor-regulated calcium reabsorption	10/485	59/7206	0.00549535319342
ko04626	Plant-pathogen interaction	5/485	18/7206	0.00556342810475
ko05164	Influenza A	3/485	167/7206	0.00694641781149
ko04120	Ubiquitin mediated proteolysis	2/485	138/7206	0.00873975315124
ko04930	Type II diabetes mellitus	9/485	54/7206	0.00923255325293
ko04621	NOD-like receptor signaling pathway	3/485	157/7206	0.00935606777356
ko04371	Apelin signaling pathway	21/485	177/7206	0.00940228172401
ko04141	Protein processing in endoplasmic reticulum	4/485	184/7206	0.0101931221377
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/485	14/7206	0.0117946137868
ko00250	Alanine, aspartate and glutamate metabolism	7/485	38/7206	0.0121907812395
ko05146	Amoebiasis	1/485	99/7206	0.0141174584861
ko00010	Glycolysis / Gluconeogenesis	11/485	74/7206	0.0156534967067
ko04978	Mineral absorption	7/485	40/7206	0.0160420588549
ko05166	HTLV-I infection	10/485	292/7206	0.0169730178028
ko03013	RNA transport	4/485	166/7206	0.0183698899232
ko04973	Carbohydrate digestion and absorption	7/485	42/7206	0.0206847327699
ko05010	Alzheimer's disease	22/485	202/7206	0.0221166045441
ko00680	Methane metabolism	6/485	34/7206	0.0241588547699
ko04932	Non-alcoholic fatty liver disease (NAFLD)	5/485	182/7206	0.0242766264543
ko05200	Pathways in cancer	21/485	492/7206	0.0247220169392
ko05162	Measles	2/485	120/7206	0.0248157223437
ko04668	TNF signaling pathway	2/485	120/7206	0.0248157223437
ko04966	Collecting duct acid secretion	5/485	26/7206	0.0274052450115
ko04657	IL-17 signaling pathway	1/485	87/7206	0.029631993971
ko04146	Peroxisome	1/485	89/7206	0.030182718079
ko05222	Small cell lung cancer	1/485	89/7206	0.030182718079
ko04210	Apoptosis	5/485	180/7206	0.033141507733
ko05215	Prostate cancer	2/485	111/7206	0.0336451944913
ko04630	Jak-STAT signaling pathway	3/485	132/7206	0.0344576270139
ko05016	Huntington's disease	7/485	215/7206	0.0373411271818
ko04114	Oocyte meiosis	16/485	139/7206	0.0373699894045
ko04750	Inflammatory mediator regulation of TRP channels	14/485	122/7206	0.0435030513543
ko05220	Chronic myeloid leukemia	1/485	85/7206	0.0450919386406
ko04914	Progesterone-mediated oocyte maturation	2/485	104/7206	0.0469248784373