ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	42/491	152/7206	1.01182338923e-15
ko04261	Adrenergic signaling in cardiomyocytes	48/491	205/7206	1.02198195931e-14
ko04713	Circadian entrainment	37/491	136/7206	9.50126107221e-14
ko04723	Retrograde endocannabinoid signaling	42/491	175/7206	2.13043855867e-13
ko04921	Oxytocin signaling pathway	45/491	209/7206	1.7830672183e-12
ko04911	Insulin secretion	30/491	117/7206	1.13559712627e-10
ko04260	Cardiac muscle contraction	27/491	98/7206	1.68687220893e-10
ko05033	Nicotine addiction	20/491	56/7206	2.49393635428e-10
ko04727	GABAergic synapse	28/491	110/7206	5.7868489681e-10
ko04020	Calcium signaling pathway	47/491	265/7206	6.94263287991e-10
ko04728	Dopaminergic synapse	37/491	185/7206	1.6754035252e-09
ko05010	Alzheimer's disease	39/491	202/7206	1.74784864639e-09
ko04022	cGMP-PKG signaling pathway	40/491	216/7206	3.83649874291e-09
ko04080	Neuroactive ligand-receptor interaction	62/491	423/7206	6.0003403476e-09
ko05410	Hypertrophic cardiomyopathy (HCM)	25/491	100/7206	7.36775544378e-09
ko04725	Cholinergic synapse	32/491	160/7206	2.19807139169e-08
ko04970	Salivary secretion	23/491	95/7206	5.68075975388e-08
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	20/491	79/7206	1.91727103671e-07
ko04721	Synaptic vesicle cycle	20/491	80/7206	2.39725782143e-07
ko05414	Dilated cardiomyopathy	24/491	112/7206	3.46743905912e-07
ko05032	Morphine addiction	23/491	110/7206	9.65660987341e-07
ko04024	cAMP signaling pathway	42/491	279/7206	1.17637460098e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	18/491	74/7206	1.48779506325e-06
ko05031	Amphetamine addiction	20/491	91/7206	2.18610612514e-06
ko04720	Long-term potentiation	21/491	99/7206	2.24635606238e-06
ko04726	Serotonergic synapse	25/491	137/7206	4.57811208867e-06
ko00190	Oxidative phosphorylation	23/491	127/7206	1.25554447156e-05
ko04922	Glucagon signaling pathway	23/491	128/7206	1.43525086484e-05
ko04371	Apelin signaling pathway	28/491	177/7206	2.43407433997e-05
ko04971	Gastric acid secretion	19/491	98/7206	2.65945885203e-05
ko00010	Glycolysis / Gluconeogenesis	16/491	74/7206	2.82683881361e-05
ko04010	MAPK signaling pathway	42/491	321/7206	3.43347887786e-05
ko04360	Axon guidance	33/491	233/7206	5.08360960908e-05
ko04730	Long-term depression	16/491	78/7206	5.60526754831e-05
ko05168	Herpes simplex infection	1/491	182/7206	6.83833143816e-05
ko04964	Proximal tubule bicarbonate reclamation	9/491	29/7206	8.59559935639e-05
ko04626	Plant-pathogen interaction	7/491	18/7206	0.000107345679218
ko04745	Phototransduction - fly	10/491	38/7206	0.000163566859913
ko05322	Systemic lupus erythematosus	1/491	151/7206	0.000463276720579
ko04924	Renin secretion	15/491	86/7206	0.000615187784628
ko04925	Aldosterone synthesis and secretion	17/491	105/7206	0.000668643503979
ko03040	Spliceosome	1/491	145/7206	0.000679980728238
ko05012	Parkinson's disease	22/491	155/7206	0.000960574610469
ko04120	Ubiquitin mediated proteolysis	1/491	138/7206	0.000994361168232
ko04550	Signaling pathways regulating pluripotency of stem cells	2/491	165/7206	0.00143436397169
ko03013	RNA transport	2/491	166/7206	0.00146116262622
ko00680	Methane metabolism	8/491	34/7206	0.00164105529747
ko04972	Pancreatic secretion	17/491	111/7206	0.00164376736343
ko04740	Olfactory transduction	13/491	80/7206	0.0027037249822
ko05030	Cocaine addiction	12/491	73/7206	0.00352753548081
ko01200	Carbon metabolism	18/491	128/7206	0.0036464265833
ko04514	Cell adhesion molecules (CAMs)	18/491	130/7206	0.00397508576314
ko05164	Influenza A	3/491	167/7206	0.00476562068186
ko04978	Mineral absorption	8/491	40/7206	0.00484792095514
ko00030	Pentose phosphate pathway	7/491	32/7206	0.00493134914378
ko05203	Viral carcinogenesis	8/491	277/7206	0.00499388968769
ko04960	Aldosterone-regulated sodium reabsorption	8/491	41/7206	0.00567329465881
ko04961	Endocrine and other factor-regulated calcium reabsorption	10/491	59/7206	0.00598770569664
ko04973	Carbohydrate digestion and absorption	8/491	42/7206	0.00660150380696
ko04150	mTOR signaling pathway	4/491	184/7206	0.00711538653214
ko04742	Taste transduction	10/491	61/7206	0.00760872436601
ko04630	Jak-STAT signaling pathway	2/491	132/7206	0.00834481939754
ko00710	Carbon fixation in photosynthetic organisms	6/491	27/7206	0.00839152511286
ko05166	HTLV-I infection	9/491	292/7206	0.00850415504988
ko05416	Viral myocarditis	9/491	55/7206	0.0112251577113
ko04142	Lysosome	3/491	151/7206	0.0131619436678
ko05161	Hepatitis B	4/491	173/7206	0.0135389994776
ko04270	Vascular smooth muscle contraction	19/491	154/7206	0.0137414720795
ko02024	Quorum sensing	4/491	15/7206	0.015895097256
ko04114	Oocyte meiosis	17/491	139/7206	0.0163069755217
ko05162	Measles	2/491	120/7206	0.0167726062472
ko05016	Huntington's disease	24/491	215/7206	0.0182231742012
ko04140	Autophagy - animal	4/491	164/7206	0.0183348155623
ko04930	Type II diabetes mellitus	8/491	54/7206	0.0285478039953
ko04966	Collecting duct acid secretion	5/491	26/7206	0.028720746477
ko00020	Citrate cycle (TCA cycle)	6/491	35/7206	0.0290607968528
ko04657	IL-17 signaling pathway	1/491	87/7206	0.029801487309
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/491	182/7206	0.0350190458341
ko04152	AMPK signaling pathway	18/491	161/7206	0.0375755810917
ko00250	Alanine, aspartate and glutamate metabolism	6/491	38/7206	0.0416699018875
ko04912	GnRH signaling pathway	14/491	122/7206	0.0458990295678
ko01230	Biosynthesis of amino acids	11/491	85/7206	0.0460977196028
ko01522	Endocrine resistance	3/491	124/7206	0.0471971351127
ko04914	Progesterone-mediated oocyte maturation	2/491	104/7206	0.0472508418615