ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 17/128 152/7206 1.09161182481e-09 ko04727 GABAergic synapse 12/128 110/7206 4.72253217642e-07 ko04713 Circadian entrainment 13/128 136/7206 7.21331603006e-07 ko04728 Dopaminergic synapse 15/128 185/7206 8.21381858678e-07 ko04915 Estrogen signaling pathway 12/128 131/7206 3.10604937497e-06 ko05032 Morphine addiction 11/128 110/7206 3.46469249387e-06 ko04925 Aldosterone synthesis and secretion 10/128 105/7206 1.52053591515e-05 ko04020 Calcium signaling pathway 16/128 265/7206 1.63731755579e-05 ko05031 Amphetamine addiction 9/128 91/7206 3.04759926813e-05 ko04911 Insulin secretion 10/128 117/7206 3.92715642493e-05 ko05030 Cocaine addiction 8/128 73/7206 4.06382770058e-05 ko04723 Retrograde endocannabinoid signaling 12/128 175/7206 5.91468995511e-05 ko04720 Long-term potentiation 9/128 99/7206 5.9729577277e-05 ko04725 Cholinergic synapse 11/128 160/7206 0.000118879319502 ko04072 Phospholipase D signaling pathway 12/128 197/7206 0.00018383101993 ko04261 Adrenergic signaling in cardiomyocytes 12/128 205/7206 0.000266387704279 ko04912 GnRH signaling pathway 9/128 122/7206 0.000298621517955 ko04024 cAMP signaling pathway 14/128 279/7206 0.000403567203173 ko04923 Regulation of lipolysis in adipocytes 7/128 77/7206 0.000405605228219 ko05033 Nicotine addiction 6/128 56/7206 0.000438243767084 ko04080 Neuroactive ligand-receptor interaction 18/128 423/7206 0.000450080787885 ko04740 Olfactory transduction 7/128 80/7206 0.000512735171775 ko04012 ErbB signaling pathway 8/128 109/7206 0.000673649084008 ko04742 Taste transduction 6/128 61/7206 0.000697157344114 ko04360 Axon guidance 12/128 233/7206 0.000845857267027 ko04062 Chemokine signaling pathway 11/128 201/7206 0.0008499235748 ko04022 cGMP-PKG signaling pathway 11/128 216/7206 0.00152785656373 ko00512 Mucin type O-glycan biosynthesis 4/128 29/7206 0.00159900772561 ko04971 Gastric acid secretion 7/128 98/7206 0.00171570561146 ko04540 Gap junction 8/128 128/7206 0.00191482646974 ko04914 Progesterone-mediated oocyte maturation 7/128 104/7206 0.00241350187111 ko05231 Choline metabolism in cancer 8/128 134/7206 0.00255443193396 ko05214 Glioma 6/128 79/7206 0.00269192579375 ko04916 Melanogenesis 8/128 142/7206 0.00365510340769 ko04015 Rap1 signaling pathway 12/128 278/7206 0.00375409822336 ko04213 Longevity regulating pathway - multiple species 6/128 86/7206 0.00411729966236 ko04918 Thyroid hormone synthesis 6/128 86/7206 0.00411729966236 ko04371 Apelin signaling pathway 9/128 177/7206 0.00413091632498 ko04750 Inflammatory mediator regulation of TRP channels 7/128 122/7206 0.0058546648312 ko04270 Vascular smooth muscle contraction 8/128 154/7206 0.00595709673513 ko04211 Longevity regulating pathway 7/128 123/7206 0.00611835539111 ko04973 Carbohydrate digestion and absorption 4/128 42/7206 0.00630997977863 ko01522 Endocrine resistance 7/128 124/7206 0.00639083286796 ko04970 Salivary secretion 6/128 95/7206 0.00668928968848 ko04611 Platelet activation 8/128 163/7206 0.00830805677169 ko00515 Mannose type O-glycan biosynthesis 3/128 25/7206 0.00946415280455 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 3/128 26/7206 0.0105618129133 ko04726 Serotonergic synapse 7/128 137/7206 0.0108126107047 ko01521 EGFR tyrosine kinase inhibitor resistance 6/128 106/7206 0.0112186402785 ko04921 Oxytocin signaling pathway 9/128 209/7206 0.0118577340636 ko04070 Phosphatidylinositol signaling system 6/128 112/7206 0.0144428383437 ko05414 Dilated cardiomyopathy 6/128 112/7206 0.0144428383437 ko04924 Renin secretion 5/128 86/7206 0.018121905693 ko04666 Fc gamma R-mediated phagocytosis 6/128 122/7206 0.0211660084886 ko04913 Ovarian steroidogenesis 4/128 63/7206 0.0252785794633 ko04922 Glucagon signaling pathway 6/128 128/7206 0.0260822703751 ko05223 Non-small cell lung cancer 4/128 66/7206 0.029378186016 ko04341 Hedgehog signaling pathway - fly 3/128 38/7206 0.0293910071903 ko04910 Insulin signaling pathway 7/128 172/7206 0.0331300914398 ko04919 Thyroid hormone signaling pathway 6/128 143/7206 0.0415428034246 ko04972 Pancreatic secretion 5/128 111/7206 0.0471777781267 ko04730 Long-term depression 4/128 78/7206 0.0495301816162