ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1233	423/7206	2.96432741422e-50
ko04724	Glutamatergic synapse	93/1233	152/7206	7.57438287659e-35
ko05033	Nicotine addiction	50/1233	56/7206	2.2422650525e-32
ko05032	Morphine addiction	72/1233	110/7206	6.82051326194e-30
ko04713	Circadian entrainment	79/1233	136/7206	1.52268835354e-27
ko04727	GABAergic synapse	68/1233	110/7206	4.32467019586e-26
ko04721	Synaptic vesicle cycle	52/1233	80/7206	1.12105078561e-21
ko04728	Dopaminergic synapse	86/1233	185/7206	5.28918372458e-21
ko04725	Cholinergic synapse	78/1233	160/7206	1.00340459913e-20
ko04723	Retrograde endocannabinoid signaling	80/1233	175/7206	4.72644248989e-19
ko04024	cAMP signaling pathway	108/1233	279/7206	1.72776392711e-18
ko04020	Calcium signaling pathway	101/1233	265/7206	1.1653137982e-16
ko04911	Insulin secretion	58/1233	117/7206	3.95144926084e-16
ko04742	Taste transduction	38/1233	61/7206	2.88670585634e-15
ko04921	Oxytocin signaling pathway	81/1233	209/7206	3.92972314453e-14
ko04261	Adrenergic signaling in cardiomyocytes	77/1233	205/7206	1.17674614244e-12
ko04744	Phototransduction	25/1233	36/7206	4.78675929337e-12
ko04726	Serotonergic synapse	57/1233	137/7206	1.34326035064e-11
ko05031	Amphetamine addiction	43/1233	91/7206	2.10951063297e-11
ko04720	Long-term potentiation	45/1233	99/7206	3.76979208291e-11
ko03040	Spliceosome	1/1233	145/7206	7.25152522695e-11
ko04970	Salivary secretion	43/1233	95/7206	1.22080691767e-10
ko04360	Axon guidance	79/1233	233/7206	2.46433958184e-10
ko05203	Viral carcinogenesis	16/1233	277/7206	1.94460602242e-08
ko04740	Olfactory transduction	35/1233	80/7206	1.95461583784e-08
ko04971	Gastric acid secretion	40/1233	98/7206	3.02489610893e-08
ko04925	Aldosterone synthesis and secretion	41/1233	105/7206	6.57360974258e-08
ko05168	Herpes simplex infection	8/1233	182/7206	2.21175412639e-07
ko05030	Cocaine addiction	31/1233	73/7206	2.87267938011e-07
ko04022	cGMP-PKG signaling pathway	67/1233	216/7206	3.1490094838e-07
ko03013	RNA transport	7/1233	166/7206	5.72863760339e-07
ko05322	Systemic lupus erythematosus	6/1233	151/7206	9.754632473e-07
ko04060	Cytokine-cytokine receptor interaction	10/1233	191/7206	1.2205000753e-06
ko04010	MAPK signaling pathway	88/1233	321/7206	2.18185388543e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1233	74/7206	2.3304421359e-06
ko04141	Protein processing in endoplasmic reticulum	11/1233	184/7206	9.77733622357e-06
ko04972	Pancreatic secretion	38/1233	111/7206	1.01057235865e-05
ko04610	Complement and coagulation cascades	1/1233	79/7206	1.30505020061e-05
ko04745	Phototransduction - fly	18/1233	38/7206	1.48392660373e-05
ko04966	Collecting duct acid secretion	14/1233	26/7206	2.14119719408e-05
ko05110	Vibrio cholerae infection	25/1233	63/7206	2.39946718862e-05
ko05164	Influenza A	10/1233	167/7206	2.56705240198e-05
ko04070	Phosphatidylinositol signaling system	37/1233	112/7206	3.60897722907e-05
ko04730	Long-term depression	28/1233	78/7206	5.51594705014e-05
ko04924	Renin secretion	30/1233	86/7206	6.46928637322e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1233	59/7206	6.6227739426e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1233	79/7206	6.84971435604e-05
ko04540	Gap junction	40/1233	128/7206	7.25952303397e-05
ko04621	NOD-like receptor signaling pathway	10/1233	157/7206	9.61795345147e-05
ko05414	Dilated cardiomyopathy	36/1233	112/7206	0.000109669597403
ko04072	Phospholipase D signaling pathway	55/1233	197/7206	0.000112775778176
ko03008	Ribosome biogenesis in eukaryotes	2/1233	79/7206	0.000113366040439
ko05140	Leishmaniasis	2/1233	75/7206	0.000159950937466
ko04064	NF-kappa B signaling pathway	4/1233	96/7206	0.000180790138235
ko04514	Cell adhesion molecules (CAMs)	39/1233	130/7206	0.000231562137896
ko05169	Epstein-Barr virus infection	17/1233	206/7206	0.000324271146689
ko04923	Regulation of lipolysis in adipocytes	26/1233	77/7206	0.000349604478568
ko04260	Cardiac muscle contraction	31/1233	98/7206	0.000366218740292
ko05205	Proteoglycans in cancer	26/1233	271/7206	0.000516024701964
ko04014	Ras signaling pathway	70/1233	279/7206	0.000616689557618
ko04612	Antigen processing and presentation	3/1233	77/7206	0.000674398548262
ko05161	Hepatitis B	14/1233	173/7206	0.000710049280515
ko04371	Apelin signaling pathway	48/1233	177/7206	0.000770677879139
ko04976	Bile secretion	26/1233	80/7206	0.000798006478535
ko00480	Glutathione metabolism	1/1233	55/7206	0.000859052113142
ko04110	Cell cycle	11/1233	145/7206	0.00114404064594
ko04120	Ubiquitin mediated proteolysis	10/1233	138/7206	0.00123794697814
ko00590	Arachidonic acid metabolism	1/1233	52/7206	0.00125717592765
ko05162	Measles	8/1233	120/7206	0.0013035909225
ko04626	Plant-pathogen interaction	9/1233	18/7206	0.00135360926076
ko04915	Estrogen signaling pathway	37/1233	131/7206	0.00140356083151
ko04146	Peroxisome	5/1233	89/7206	0.00253589746573
ko03420	Nucleotide excision repair	1/1233	46/7206	0.00281801669935
ko04750	Inflammatory mediator regulation of TRP channels	34/1233	122/7206	0.00327675045016
ko05321	Inflammatory bowel disease (IBD)	2/1233	56/7206	0.00375213283672
ko03022	Basal transcription factors	1/1233	44/7206	0.00424895176302
ko04640	Hematopoietic cell lineage	3/1233	64/7206	0.00433524166798
ko05144	Malaria	1/1233	45/7206	0.00437422660431
ko00071	Fatty acid degradation	1/1233	45/7206	0.00437422660431
ko00240	Pyrimidine metabolism	8/1233	110/7206	0.00457014771177
ko04115	p53 signaling pathway	4/1233	74/7206	0.00469154909397
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1233	14/7206	0.00474472881989
ko04622	RIG-I-like receptor signaling pathway	3/1233	62/7206	0.00622520690091
ko00140	Steroid hormone biosynthesis	1/1233	41/7206	0.0064125448883
ko04214	Apoptosis - fly	4/1233	72/7206	0.00671886890437
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1233	182/7206	0.00696991274152
ko04658	Th1 and Th2 cell differentiation	7/1233	96/7206	0.00883877453354
ko04210	Apoptosis	18/1233	180/7206	0.00890187164247
ko04657	IL-17 signaling pathway	6/1233	87/7206	0.00919647244262
ko05133	Pertussis	6/1233	87/7206	0.00919647244262
ko00330	Arginine and proline metabolism	3/1233	61/7206	0.00923704985796
ko03320	PPAR signaling pathway	4/1233	69/7206	0.00936466462511
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1233	40/7206	0.00982642485672
ko04964	Proximal tubule bicarbonate reclamation	11/1233	29/7206	0.0103391994602
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1233	100/7206	0.0109766914234
ko05145	Toxoplasmosis	11/1233	126/7206	0.0115703680078
ko03018	RNA degradation	6/1233	84/7206	0.0124928063995
ko04916	Melanogenesis	36/1233	142/7206	0.0127333377959
ko01524	Platinum drug resistance	5/1233	76/7206	0.0131937221548
ko04918	Thyroid hormone synthesis	24/1233	86/7206	0.013285643938
ko04630	Jak-STAT signaling pathway	12/1233	132/7206	0.0136521846241
ko04510	Focal adhesion	27/1233	240/7206	0.0143179277916
ko00982	Drug metabolism - cytochrome P450	1/1233	37/7206	0.0144960548171
ko00630	Glyoxylate and dicarboxylate metabolism	1/1233	38/7206	0.0150481044574
ko05222	Small cell lung cancer	7/1233	89/7206	0.0159128468155
ko05131	Shigellosis	6/1233	82/7206	0.0172127319952
ko00310	Lysine degradation	5/1233	73/7206	0.0179943532199
ko04912	GnRH signaling pathway	31/1233	122/7206	0.0204269086648
ko05215	Prostate cancer	10/1233	111/7206	0.0215562336757
ko00500	Starch and sucrose metabolism	1/1233	35/7206	0.0219642016305
ko04015	Rap1 signaling pathway	62/1233	278/7206	0.0227380399523
ko05166	HTLV-I infection	36/1233	292/7206	0.0261857439394
ko04670	Leukocyte transendothelial migration	16/1233	151/7206	0.0290356225266
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1233	15/7206	0.0307143626523
ko05418	Fluid shear stress and atherosclerosis	19/1233	173/7206	0.0313584583792
ko04620	Toll-like receptor signaling pathway	9/1233	100/7206	0.0314126055793
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1233	26/7206	0.0314185112836
ko00562	Inositol phosphate metabolism	23/1233	89/7206	0.0332988707122
ko04217	Necroptosis	20/1233	178/7206	0.0341656965483
ko00380	Tryptophan metabolism	3/1233	50/7206	0.0365941403843
ko04668	TNF signaling pathway	12/1233	120/7206	0.0372081182163
ko04270	Vascular smooth muscle contraction	36/1233	154/7206	0.0400888290246
ko04114	Oocyte meiosis	33/1233	139/7206	0.0405658222775
ko04922	Glucagon signaling pathway	31/1233	128/7206	0.0430069642761
ko04930	Type II diabetes mellitus	15/1233	54/7206	0.0450659870589
ko05320	Autoimmune thyroid disease	1/1233	29/7206	0.0481564148871
ko05340	Primary immunodeficiency	1/1233	30/7206	0.0487480427072