ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	199/1261	423/7206	6.60624375445e-48
ko04724	Glutamatergic synapse	94/1261	152/7206	6.24879955979e-35
ko05033	Nicotine addiction	50/1261	56/7206	6.8576203509e-32
ko05032	Morphine addiction	74/1261	110/7206	3.15393601107e-31
ko04713	Circadian entrainment	83/1261	136/7206	2.48286954135e-30
ko04727	GABAergic synapse	70/1261	110/7206	2.46218234688e-27
ko04728	Dopaminergic synapse	91/1261	185/7206	1.19297066448e-23
ko04725	Cholinergic synapse	81/1261	160/7206	3.48509028365e-22
ko04723	Retrograde endocannabinoid signaling	83/1261	175/7206	2.35231679576e-20
ko04721	Synaptic vesicle cycle	50/1261	80/7206	2.39803963875e-19
ko04024	cAMP signaling pathway	110/1261	279/7206	8.74261775857e-19
ko04020	Calcium signaling pathway	105/1261	265/7206	4.37675085268e-18
ko04911	Insulin secretion	59/1261	117/7206	2.31420445002e-16
ko04921	Oxytocin signaling pathway	83/1261	209/7206	1.38873699728e-14
ko04726	Serotonergic synapse	62/1261	137/7206	2.68056160546e-14
ko04742	Taste transduction	37/1261	61/7206	4.78321693118e-14
ko04744	Phototransduction	27/1261	36/7206	5.33149007224e-14
ko04261	Adrenergic signaling in cardiomyocytes	79/1261	205/7206	4.2223671063e-13
ko04360	Axon guidance	84/1261	233/7206	7.39462964114e-12
ko05031	Amphetamine addiction	44/1261	91/7206	1.00740375199e-11
ko03040	Spliceosome	1/1261	145/7206	2.6489485636e-11
ko04720	Long-term potentiation	45/1261	99/7206	8.24339299927e-11
ko04970	Salivary secretion	42/1261	95/7206	1.02303958337e-09
ko04925	Aldosterone synthesis and secretion	43/1261	105/7206	1.26516356085e-08
ko04022	cGMP-PKG signaling pathway	71/1261	216/7206	2.74077800438e-08
ko05030	Cocaine addiction	33/1261	73/7206	3.2801337859e-08
ko04971	Gastric acid secretion	40/1261	98/7206	4.63743006805e-08
ko04010	MAPK signaling pathway	94/1261	321/7206	1.04594682594e-07
ko05322	Systemic lupus erythematosus	5/1261	151/7206	1.04629585985e-07
ko03013	RNA transport	7/1261	166/7206	2.52202682726e-07
ko05203	Viral carcinogenesis	19/1261	277/7206	2.69368272555e-07
ko04740	Olfactory transduction	33/1261	80/7206	6.55615584847e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1261	74/7206	6.91606191291e-07
ko04060	Cytokine-cytokine receptor interaction	11/1261	191/7206	1.70543978924e-06
ko04070	Phosphatidylinositol signaling system	40/1261	112/7206	3.53889084687e-06
ko04972	Pancreatic secretion	39/1261	111/7206	6.56482407407e-06
ko04923	Regulation of lipolysis in adipocytes	30/1261	77/7206	6.60795043397e-06
ko04924	Renin secretion	32/1261	86/7206	1.08366909333e-05
ko04014	Ras signaling pathway	78/1261	279/7206	1.19177608815e-05
ko04072	Phospholipase D signaling pathway	59/1261	197/7206	1.47173928084e-05
ko04141	Protein processing in endoplasmic reticulum	12/1261	184/7206	1.8624892695e-05
ko04745	Phototransduction - fly	18/1261	38/7206	2.04362148616e-05
ko04730	Long-term depression	29/1261	78/7206	3.0517780859e-05
ko04711	Circadian rhythm - fly	9/1261	13/7206	5.44887751492e-05
ko05168	Herpes simplex infection	13/1261	182/7206	6.52967219691e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1261	79/7206	7.04845457196e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1261	59/7206	8.51350112619e-05
ko04064	NF-kappa B signaling pathway	4/1261	96/7206	0.00012027355748
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1261	79/7206	0.000131100889876
ko04540	Gap junction	40/1261	128/7206	0.00013640339872
ko05414	Dilated cardiomyopathy	36/1261	112/7206	0.000136431812135
ko04371	Apelin signaling pathway	50/1261	177/7206	0.000400238492553
ko05164	Influenza A	13/1261	167/7206	0.000409831719573
ko04915	Estrogen signaling pathway	39/1261	131/7206	0.000447733834347
ko04612	Antigen processing and presentation	3/1261	77/7206	0.000450519662141
ko04621	NOD-like receptor signaling pathway	12/1261	157/7206	0.000596448094082
ko05110	Vibrio cholerae infection	22/1261	63/7206	0.000729179962432
ko04640	Hematopoietic cell lineage	2/1261	64/7206	0.000763820651941
ko04514	Cell adhesion molecules (CAMs)	38/1261	130/7206	0.000967376567684
ko04750	Inflammatory mediator regulation of TRP channels	36/1261	122/7206	0.00102823836242
ko05205	Proteoglycans in cancer	28/1261	271/7206	0.00106346687168
ko00330	Arginine and proline metabolism	2/1261	61/7206	0.00113583565169
ko04260	Cardiac muscle contraction	30/1261	98/7206	0.00120914409445
ko04146	Peroxisome	5/1261	89/7206	0.00172484347235
ko04710	Circadian rhythm	16/1261	43/7206	0.00187694370869
ko04110	Cell cycle	12/1261	145/7206	0.00189172860274
ko05169	Epstein-Barr virus infection	20/1261	206/7206	0.00203170235081
ko04966	Collecting duct acid secretion	11/1261	26/7206	0.00267405554349
ko05144	Malaria	1/1261	45/7206	0.0027582150719
ko03420	Nucleotide excision repair	1/1261	46/7206	0.00279218972055
ko05140	Leishmaniasis	4/1261	75/7206	0.00324875707506
ko00240	Pyrimidine metabolism	8/1261	110/7206	0.00328613236943
ko00480	Glutathione metabolism	2/1261	55/7206	0.00369654556711
ko04912	GnRH signaling pathway	34/1261	122/7206	0.00376314622545
ko03022	Basal transcription factors	1/1261	44/7206	0.00428328290899
ko04120	Ubiquitin mediated proteolysis	12/1261	138/7206	0.00444753574917
ko05162	Measles	10/1261	120/7206	0.00522412362392
ko00590	Arachidonic acid metabolism	2/1261	52/7206	0.00537879077287
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1261	14/7206	0.00540397805932
ko05231	Choline metabolism in cancer	36/1261	134/7206	0.00573392758985
ko04930	Type II diabetes mellitus	18/1261	54/7206	0.00584741342277
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1261	40/7206	0.00630860430245
ko00140	Steroid hormone biosynthesis	1/1261	41/7206	0.00631384804402
ko00515	Mannose type O-glycan biosynthesis	10/1261	25/7206	0.00668468164242
ko04976	Bile secretion	24/1261	80/7206	0.0069301099804
ko04626	Plant-pathogen interaction	8/1261	18/7206	0.00717112742871
ko04015	Rap1 signaling pathway	66/1261	278/7206	0.00768015289385
ko04722	Neurotrophin signaling pathway	41/1261	160/7206	0.00836762900358
ko03018	RNA degradation	6/1261	84/7206	0.00892075095719
ko00630	Glyoxylate and dicarboxylate metabolism	1/1261	38/7206	0.00945516337118
ko03410	Base excision repair	1/1261	38/7206	0.00945516337118
ko05161	Hepatitis B	18/1261	173/7206	0.0111303499052
ko00562	Inositol phosphate metabolism	25/1261	89/7206	0.0112755619026
ko00260	Glycine, serine and threonine metabolism	2/1261	48/7206	0.0117475476129
ko05321	Inflammatory bowel disease (IBD)	3/1261	56/7206	0.0125843246609
ko04115	p53 signaling pathway	5/1261	74/7206	0.0128789025346
ko00982	Drug metabolism - cytochrome P450	1/1261	37/7206	0.0146890077808
ko04918	Thyroid hormone synthesis	24/1261	86/7206	0.0147240994917
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1261	100/7206	0.0164340877229
ko00071	Fatty acid degradation	2/1261	45/7206	0.0168905516564
ko04622	RIG-I-like receptor signaling pathway	4/1261	62/7206	0.0180410491301
ko04922	Glucagon signaling pathway	33/1261	128/7206	0.018224685182
ko04964	Proximal tubule bicarbonate reclamation	10/1261	29/7206	0.024782614477
ko04217	Necroptosis	20/1261	178/7206	0.0274272537355
ko04062	Chemokine signaling pathway	47/1261	201/7206	0.0301334409296
ko04213	Longevity regulating pathway - multiple species	23/1261	86/7206	0.0311210011664
ko04114	Oocyte meiosis	34/1261	139/7206	0.0324117210669
ko04916	Melanogenesis	35/1261	142/7206	0.0331809697879
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1261	15/7206	0.0339821366942
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1261	26/7206	0.0340101734059
ko04071	Sphingolipid signaling pathway	39/1261	162/7206	0.0356904640766
ko05016	Huntington's disease	26/1261	215/7206	0.0356907976753
ko05204	Chemical carcinogenesis	3/1261	48/7206	0.03600070993
ko04210	Apoptosis	21/1261	180/7206	0.0367519108682
ko00380	Tryptophan metabolism	3/1261	50/7206	0.0372829047381
ko04670	Leukocyte transendothelial migration	17/1261	151/7206	0.0398042188539
ko04142	Lysosome	17/1261	151/7206	0.0398042188539
ko04270	Vascular smooth muscle contraction	37/1261	154/7206	0.0408272033272
ko00310	Lysine degradation	6/1261	73/7206	0.0423299538936
ko05320	Autoimmune thyroid disease	1/1261	29/7206	0.0478541563831
ko00280	Valine, leucine and isoleucine degradation	4/1261	54/7206	0.0483037485088