ko pathway ratio_in_study ratio_in_pop p_value ko04668 TNF signaling pathway 9/89 120/7206 1.51403525475e-05 ko04270 Vascular smooth muscle contraction 9/89 154/7206 0.000108782822928 ko04380 Osteoclast differentiation 8/89 134/7206 0.00023108465227 ko04610 Complement and coagulation cascades 6/89 79/7206 0.000404220861901 ko05164 Influenza A 8/89 167/7206 0.00100831996576 ko04064 NF-kappa B signaling pathway 6/89 96/7206 0.00114041345558 ko04931 Insulin resistance 7/89 137/7206 0.00145026655637 ko04920 Adipocytokine signaling pathway 5/89 89/7206 0.00471962957816 ko04630 Jak-STAT signaling pathway 6/89 132/7206 0.00565847866597 ko04371 Apelin signaling pathway 7/89 177/7206 0.00607328098115 ko04210 Apoptosis 7/89 180/7206 0.00664518325327 ko05160 Hepatitis C 6/89 153/7206 0.0113585500786 ko04621 NOD-like receptor signaling pathway 6/89 157/7206 0.012786758902 ko04623 Cytosolic DNA-sensing pathway 3/89 41/7206 0.0138423126786 ko04921 Oxytocin signaling pathway 7/89 209/7206 0.014435616418 ko04611 Platelet activation 6/89 163/7206 0.0151596732091 ko04068 FoxO signaling pathway 6/89 167/7206 0.0169024547906 ko04211 Longevity regulating pathway 5/89 123/7206 0.0177435358617 ko05161 Hepatitis B 6/89 173/7206 0.0197694909128 ko04922 Glucagon signaling pathway 5/89 128/7206 0.0207154719057 ko05142 Chagas disease (American trypanosomiasis) 5/89 130/7206 0.0219902810939 ko04217 Necroptosis 6/89 178/7206 0.0223998737808 ko05323 Rheumatoid arthritis 4/89 89/7206 0.0239633829754 ko05168 Herpes simplex infection 6/89 182/7206 0.0246678201159 ko00120 Primary bile acid biosynthesis 2/89 20/7206 0.0248086327668 ko04933 AGE-RAGE signaling pathway in diabetic complications 5/89 135/7206 0.0253983123922 ko05120 Epithelial cell signaling in Helicobacter pylori infection 4/89 92/7206 0.0266752720782 ko05166 HTLV-I infection 8/89 292/7206 0.0272643071304 ko04510 Focal adhesion 7/89 240/7206 0.0283922531481 ko04974 Protein digestion and absorption 4/89 96/7206 0.0305675384165 ko05132 Salmonella infection 4/89 98/7206 0.0326332844173 ko04971 Gastric acid secretion 4/89 98/7206 0.0326332844173 ko04620 Toll-like receptor signaling pathway 4/89 100/7206 0.0347792980158 ko04622 RIG-I-like receptor signaling pathway 3/89 62/7206 0.0408532521981 ko04725 Cholinergic synapse 5/89 160/7206 0.0474329812905